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Better diagnostic tests needed to guide HER2 breast cancer treatment, study suggests

A new study by researchers at Yale Cancer Center shows using current standard human epidermal growth factor receptor 2 (HER2) assays as a diagnostic test may result in a mis-assignment of patients for treatment for breast cancer with a promising new drug.

3 Feb 2022

Innate and adaptive immune responses to SARS-CoV-2 in convalescent children and adults

In a new study, researchers explored the systemic immune responses during the acute and convalescent phases of SARS-CoV-2 in children and adults with the same disease severity.

3 Feb 2022

Neutralizing antibodies against SARS-CoV-2 variants induced by homologous and heterologous COVID-19 booster vaccination

In this study, scientists focused on identifying tentative cut-offs for large-scale evaluations of immune protection against SARS-CoV-2 and its variants.

3 Feb 2022

Red foxes susceptible to SARS-CoV-2 infection

Working towards the aim to determine the SARS-CoV-2 susceptibility of common wildlife species, the researchers in the United States have found that red fox (Vulpes vulpes) can experimentally become infected with SARS-CoV-2 and can shed virus in its oral and nasal secretions.

3 Feb 2022

Nanoparticle vaccine effective against eight SARS-CoV-2 variants in non-human primates

Researchers demonstrate that SARS-CoV-2 RBD-based nanoparticle vaccine induces neutralizing antibodies against SARS-CoV-2 variants.

2 Feb 2022

Antigenic map of SARS-CoV-2 variants reveals amino acid substitutions that govern immune escape and immunodominance

Researchers use antigenic cartography to analyze cross-reactivity patterns of eight groups of human sera on a panel of SARS-CoV-2 variants.

2 Feb 2022

Booster dose of Covaxin vaccine candidate neutralizes Omicron and Delta variants

Researchers evaluate the neutralization potential of sera samples from subjects boosted with the Covaxin against the SARS-CoV-2 Omicron variant.

2 Feb 2022

Rapid antigen test for SARS-CoV-2 shows lower sensitivity

In a new study, researchers assessed a rapid antigen (Ag) test for SARS-CoV-2.

2 Feb 2022

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

In a new study, researchers demonstrated that a commercial real-time polymerase chain reaction (RT-PCR) assay rapidly detects the SARS-CoV-2 Omicron variant.

2 Feb 2022

The ability of individuals to cross-recognize the Omicron spike protein following vaccination or prior infection

Scientists studied the ability of T cells to react with the Omicron spike.

2 Feb 2022

Rapid dominance of Omicron following its introduction to three Massachusetts universities

Researchers from the United States assessed the rapid dominance of the SARS-CoV-2 Omicron variant in three highly vaccinated Massachusetts university populations.

2 Feb 2022

Scientists describe a smell sensory map in fruit flies

The distinctive smell of a flower.. the unmistakable aroma of coffee… the dangers linked with inhaling smoke fumes. Sensory systems have evolved to provide us with immediate, finely tuned information about the world around us, whether they are colors processed through our visual system or certain pitches interpreted through our hearing.

2 Feb 2022

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Researchers develop a single-use sensor strip to detect cerebrospinal fluid leaks

Developing rapid clinical testing for cerebrospinal fluid (CSF) leaks after trauma, surgery, tumors, and other defects are vital, because such leaks can cause life-threatening conditions, such as meningitis and intercranial infection.

1 Feb 2022

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

Researchers analyze the neutralizing antibody levels against SARS-CoV-2 VOCs in individuals after receiving their second and third doses.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

In a new study, a team of researchers assessed the neutralizing activity of XAV-19, a glyco-humanized polyclonal antibody derived from hyperimmunized animal hosts, against the SARS-CoV-2 Omicron variant.

1 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

In a new study, researchers reported the first evidence of natural SARS-CoV-2 infections among domestic rabbits in France.

1 Feb 2022

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

In a new study, researchers evaluated the neutralizing antibody titers in mice vaccinated with messenger ribonucleic acid (mRNA) encoding SARS-CoV-2 spike (S) protein.

1 Feb 2022

Assay News and Research

Better diagnostic tests needed to guide HER2 breast cancer treatment, study suggests

Innate and adaptive immune responses to SARS-CoV-2 in convalescent children and adults

Neutralizing antibodies against SARS-CoV-2 variants induced by homologous and heterologous COVID-19 booster vaccination

Red foxes susceptible to SARS-CoV-2 infection

Nanoparticle vaccine effective against eight SARS-CoV-2 variants in non-human primates

Antigenic map of SARS-CoV-2 variants reveals amino acid substitutions that govern immune escape and immunodominance

Booster dose of Covaxin vaccine candidate neutralizes Omicron and Delta variants

Rapid antigen test for SARS-CoV-2 shows lower sensitivity

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

The ability of individuals to cross-recognize the Omicron spike protein following vaccination or prior infection

Rapid dominance of Omicron following its introduction to three Massachusetts universities

Scientists describe a smell sensory map in fruit flies

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Researchers develop a single-use sensor strip to detect cerebrospinal fluid leaks

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

Mutational analysis of SARS-CoV-2 main protease

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

eBook: Using iPSCs models for human disease research and drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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