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Gelatin-based nanoparticles deliver therapeutic genes to human breast cancer

Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice.

14 Apr 2007

Genes set scene for metastasis - promote spread of breast cancer to the lungs

Biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor.

12 Apr 2007

Three proteins could be new targets for treating stroke, brain and spinal cord injuries

Some mature brain cells can grow new extensions when the amount of three particular proteins on their surface increases, a new study shows.

12 Apr 2007

Vitiligo gene linked to other autoimmune diseases

In a study appearing in the March 22 New England Journal of Medicine, scientists supported by the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered a connection between a specific gene and the inflammatory skin condition vitiligo, as well as a possible host of autoimmune diseases.

11 Apr 2007

Pharmacopeia announces positive results in hypertension and diabetic nephropathy trial

Pharmacopeia ( NASDAQ:PCOP ) , an innovator in the discovery and development of novel small molecule therapeutics, today announced positive results from the initial Phase 1 clinical trial of PS433540, the company's lead internal product candidate for the treatment of hypertension and diabetic nephropathy.

11 Apr 2007

Renovis and Pfizer extend research collaboration

Renovis has announced an agreement with Pfizer to extend the term of the companies' worldwide collaboration to research, develop and commercialize small molecules that target the vanilloid receptor, VR1.

11 Apr 2007

Gene finding could lead to new pathways for development of Alzheimer's therapeutics

Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimer's disease.

11 Apr 2007

Protecting brains of premature infants - new approach needed

A study of how the brain of a premature infant responds to injury has found vulnerabilities similar to those in the mature brain but also identified at least one significant difference, according to neuroscientists and neonatologists at Washington University School of Medicine in St. Louis.

11 Apr 2007

Study provides first direct link between plants and humans

The study was published in an advance online edition of the Proceedings of the National Academy of Sciences during the week of April 9, 2007.

10 Apr 2007

Modified bone marrow cells help recovery in an animal model of multiple sclerosis

These findings will need to be repeated in further animal models before the implications for human disease are clear; however, they open up an avenue of further research.

10 Apr 2007

Scientists link treatment-induced growth factor to cancer spread

In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment.

7 Apr 2007

TGF-beta inhibitors stop tumors spreading to new sites

For several types of cancer, persistently high levels of the soluble factor TGF-beta in the blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis and a poor prognosis.

7 Apr 2007

New regulatory mechanism for critical protein signaling domain

The study is being published in Science Express, an advanced online edition of the journal Science, on April 5. It will appear in the print version of Science later this spring.

7 Apr 2007

New role for sugars on proteins

In a ground-breaking study published in the top journal, Cell, Dr. James Dennis, senior investigator at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital, has discovered a new role for sugars on proteins.

7 Apr 2007

Efficacy of Guanilib confirmed for inflammatory bowel disease

Callisto Pharmaceuticals has announced additional data confirming efficacy of Guanilib, a first-in-class compound currently being developed for the treatment of inflammatory bowel disease (IBD), in two different standard animal models of experimental colitis.

7 Apr 2007

How auxin regulates TIR1 in plants provides clues to new treatments for human diseases

For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone -- auxin -- interacts with its hormone receptor, called TIR1.

5 Apr 2007

Although breast cancer mortality has declined as a whole, declines are greatest for women under 70

A new study shows that recent declines in breast cancer mortality rates have been most significant among women with estrogen receptor (ER)-positive tumors and women younger than 70.

4 Apr 2007

Insulin receptors play a critical role in promoting islet growth

A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes.

4 Apr 2007

We need to balance out our intake of omega-6 and omega-3 fatty acids

A new study suggests that people whose diets contain dramatically more of one kind of polyunsaturated fatty acid than another may be at greater risk for both clinical depression and certain inflammatory diseases.

3 Apr 2007

New blood thinner thrombin-receptor antagonist may work without bleeding risk

When studying a new blood thinner, one of the first signs the drug is working is seeing a slight increase in minor bleeding, nose bleeds and bruising, an inconvenient side effect of preventing the blood clots that are the leading cause of heart attack and stroke.

3 Apr 2007