Receptor News and Research

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New gold standard of care for overactive bladder

A major clinical trial finds that a combination of two common medications -- tolterodine (Detrol LA) and tamsulosin (Flomax) -- works better than either drug alone for men struggling with lower urinary tract symptoms, including tough-to-treat overactive bladder (OAB).

14 Nov 2006

Study shows Diovan reduced urinary protein excretion in patients with type 2 diabetes and high blood pressure

In patients with high blood pressure and type 2 diabetes, the blood pressure-lowering medication Diovan (valsartan) significantly reduced urinary protein excretion, with high doses providing the greatest sustained reduction , according to data presented at the Amer ican Heart Association's (AHA) Annual Scientific Sessions.

13 Nov 2006

Researchers use gene therapy to reduce the development of epileptic seizures

For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats.

8 Nov 2006

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Cancer biologists are always on the lookout for new methods of studying the effects that drug therapy has on malignant cells.

6 Nov 2006

Scientists spot mechanism behind promising new sleep drug

An experimental drug called gaboxadol may soon help millions of bleary-eyed insomniacs get to sleep, and a multi-center team of U.S. scientists believes they've pinpointed just how the drug works.

1 Nov 2006

New evidence says SIDS caused by abnormality in the brainstem

According to a new study by researchers in the U.S. some babies who die from sudden infant death syndrome (SIDS) do so because of an abnormality in the serotonin system in their brains.

1 Nov 2006

Weill Cornell findings could foil two potential bioterror agents - viral peptide prevents deadly Hendra, Nipah viruses from infecting cells

Two lethal and easily transmitted viruses -- both potential bioterror agents -- may soon be much less dangerous, thanks to research led by scientists at Weill Cornell Medical College in New York City.

31 Oct 2006

Race is associated with unfavorable breast cancer tumor biology

African-American women with breast cancer were more likely to have larger, later-stage tumors that were more difficult to treat and also had lower survival rates than Hispanic and Caucasian women who received the same treatment in two independent series of clinical trials examined by researchers from The University of Texas M. D. Anderson Cancer Center.

23 Oct 2006

Targeted tumor therapy has paramount consequences for future expansion of nuclear medicine

Targeted tumor therapy lobs toxic payloads directly into tumors to destroy cancer cells while leaving normal cells unharmed.

20 Oct 2006

CCR5 receptor discovery could help fight against tuberculosis, HIV

A key aspect of how the body kicks the immune system into action against tuberculosis is revealed in research published today.

20 Oct 2006

Important first step towards designing new therapies for shingles

A team of scientists at the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), has identified a human protein that helps varicella-zoster virus, the cause of chickenpox and shingles, spread from cell to cell within the body.

20 Oct 2006

Why organs fail following massive trauma

Massive trauma, say from a sabertooth tiger attack, meant immediate death for the primitive human.

17 Oct 2006

FDA approves Januvia for diabetes

The Food and Drug Administration (FDA) announced today the approval of Januvia (sitagliptin phosphate) Tablets, the first diabetes treatment approved in a new class of drugs known as DDP-4 inhibitors that enhances the body's own ability to lower elevated blood sugar.

17 Oct 2006

Roche asks European Medicines Agency for authorization to market Herceptin

Roche on Friday announced it has submitted an application with the European Medicines Agency to market its breast cancer drug Herceptin as a treatment for women living with an aggressive form of advanced-stage breast cancer, called HER2-positive, and hormone receptor-positive breast cancer, AFX/Forbes reports (AFX/Forbes, 10/13).

16 Oct 2006

Smart nanoscale bioreactors for drug delivery

In a powerful demonstration of how to build a multifunctional, smart nanoscale drug delivery system, researchers at the University of Basel have created a drug-loaded nanocontainer that targets specific cells and releases its payload when receiving a specific physiological signal.

2 Oct 2006

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer

Investigators developing an inhalable nanoparticle for treating lung cancer have shown that a surface molecule found on malignant lung cells can serve as an effective target for improving drug delivery.

25 Sep 2006

Insulin receptor stops progression of Alzheimer's disease

Stimulation of a receptor in the brain that controls insulin responses has been shown to halt or diminish the neurodegeneration of Alzheimer's disease, providing evidence that the disease can be treated in its early stages, according to a study by researchers at Rhode Island Hospital and Brown Medical School.

21 Sep 2006

Here's egg in your eye: a prospective study of blunt ocular trauma resulting from thrown eggs

As the party conference season gets under way in the UK, research in Emergency Medicine Journal shows that lobbing raw eggs at people as a harmless form of protest or prank can actually result in serious eye injury.

21 Sep 2006

Curcumin useful in the fight against colorectal cancer

Looking for a cancer cure? Try the spice rack. In the last few years, that tactic has proved productive for researchers investigating turmeric, a curry spice used for centuries in Indian traditional medicine.

19 Sep 2006

Researchers create roadmap to integrin activation

Calling it an important technical advance in the study of the complex receptors and pathways of the body's cellular system, researchers at the University of California, San Diego (UCSD) School of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critical to the control of bleeding and to the thrombosis that occurs in heart attacks and strokes.

18 Sep 2006