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Nematode hormone discovery may aid fight against parasitic disease

New research at UT Southwestern Medical Center shows that on a biochemical level, hormone-like molecules in tiny worms called nematodes work similarly to the way in which certain hormones work in humans - findings that one day may help eradicate worm infections that afflict a third of the world's population.

9 Mar 2006

G protein-coupled receptors cool passion of 'kiss and run' nerve cells

A new subtlety in the process of how the body's nervous system relays information may hinge on how "wet" the "kiss" is when one neuron fires a packet of neurotransmitter across a synapse to a receptive nerve cell.

9 Mar 2006

Novel compound may help fight obesity

A new study reveals an attractive new target for therapies aimed at the treatment of obesity and related metabolic disorders, researchers report in the March Cell Metabolism.

9 Mar 2006

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Researchers at UC Irvine have found that a new compound not only relieves the cognitive symptoms of Alzheimer's disease, but also reduces the two types of brain lesions that are hallmarks of this devastating disease, thereby blocking its progression.

7 Mar 2006

Study may lead to ways to reduce heart attacks in diabetes patients

For people with type 2 diabetes, the death rate from a first heart attack is two to three times the death rate of patients without the disease. Similarly, patients with diabetes and ischemic (reduced blood flow) heart disease have a much higher mortality rate than the general population.

7 Mar 2006

A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma

Asthma rates are rapidly increasing, particularly in children. Although asthma is mediated in part by activation of special immune cells called Th2 cells, the precise causes are unclear.

7 Mar 2006

Schering-Plough provides update on phase II study of Vicriviroc

Schering-Plough Corporation has provided an update on vicriviroc, its investigational CCR5 receptor antagonist, currently being evaluated by the NIH-sponsored Adult AIDS Clinical Trials Group (ACTG) in an ongoing Phase II clinical study of 118 U.S. treatment-experienced HIV patients.

6 Mar 2006

Night blindness is a new clinical symptom of Chagas disease

"This is a new observation, a new clinical symptom of Chagas disease," said Levin, head of the Laboratory of the Molecular Biology of Chagas Disease at the University of Buenos Aires, Argentina. Levin and colleagues report their findings in the March 2006, issue of the FASEB Journal.

1 Mar 2006

Clinical trial of new Bionovo menopause drug moves forward

Today, millions of women suffer from often-harsh symptoms of menopause such as hot flashes and night sweats -- and relief is nowhere to be found.

27 Feb 2006

Researchers transplant insulin-producing neonatal porcine islet cells into monkeys

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation.

27 Feb 2006

Ginkgo biloba reduces aggressive cancer risk in animal experiments

Researchers at Georgetown University Medical Center say they now have a clearer picture of how an extract from the leaves of the Ginkgo biloba tree reduces the risk of aggressive cancer in animal experiments.

27 Feb 2006

Xenon gas shown to be safe in surgery and could help stop nervedamaging illnesses

Scientists have successfully conducted the first clinical trial giving xenon gas to patients undergoing coronary artery bypass grafting in order to safeguard against postoperative brain damage that can occur following this procedure.

27 Feb 2006

New tool to discover molecules that can enhance or block different kinds of tastes

Researchers from the Monell Chemical Senses Center have succeeded in growing mature taste receptor cells outside the body and for the first time have been able to successfully keep the cells alive for a prolonged period of time.

27 Feb 2006

Statins lessen heart attack risk

For patients with undiagnosed heart disease, taking medications known as statins and beta-blockers may mean the difference between suffering a heart attack as a first symptom versus experiencing mild chest pain.

24 Feb 2006

New molecular target for potential drugs to treat acute respiratory distress syndrome

Researchers at the University of Virginia Health System have identified a molecular target, or receptor, for potential drugs to treat acute respiratory distress syndrome (ARDS), a sudden and life-threatening failure of the lung.

23 Feb 2006

Mutations in H5N1 avian influenza viruses

Several recent media reports have included speculations about the significance of mutations in H5N1 avian influenza viruses. Some reports have suggested that the likelihood of another pandemic may have increased as a result of changes in the virus.

21 Feb 2006

M. D. Anderson Cancer Center to investigate CTCE-9908 chemokine CXCR4 antagonist

Chemokine Therapeutics has announced that it has entered into an agreement with The University of Texas M. D. Anderson Cancer Center of Houston, Texas to study the Company's lead anti-cancer compound, CTCE-9908, a chemokine CXCR4 antagonist.

21 Feb 2006

Inflammatory reaction drives hormone resistance in cancer

In the journal Cell, researchers report new evidence to explain why prostate cancer and other hormone-dependent cancers may become resistant to hormone therapies.

21 Feb 2006

Researchers create animal model of any schizophrenic characteristics

Researchers have developed a mouse strain in which the abnormal activity of the dopamine machinery in a specific part of the brain causes cognitive and behavioral impairments mimicking those in human schizophrenics.

20 Feb 2006

New system for analyzing how drugs bind to proteins

Researchers at Florida State University's National High Magnetic Field Laboratory and Scripps Florida have developed and evaluated a robust new system for analyzing how drugs bind to proteins. This groundbreaking work could speed the delivery of potential new drugs and improve existing ones.

19 Feb 2006