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Exelixis files new drug application for a proprietary novel anticancer compound

Exelixis, Inc. has submitted an investigational new drug application (IND) to the U.S. Food and Drug Administration (FDA) for XL999, a proprietary novel anticancer compound.

29 Jun 2004

Scientists use genetic engineering to work out how odors are encoded

Yale scientists, working with the fruit fly as a model, have discovered how odors are encoded by the olfactory system into the complex messages that are sent to the brain.

26 Jun 2004

European Commission has approved the use of Herceptin® (trastuzumab) in combination with Taxotere®

The approval is based on study results which showed that for women with HER2-positive breast cancer, the combination of Herceptin and Taxotere significantly improved median life expectancy by more than one-third (31 months with Herceptin plus Taxotere vs. 22 months for Taxotere alone).

23 Jun 2004

Drug for multiple sclerosis prevented disease development when tested on animal models

Scientists from the Neurological Sciences Institute at Oregon Health & Science University have shown that an investigative drug for multiple sclerosis and related diseases prevented disease development when tested on animal models.

20 Jun 2004

Valsartan may reduce cardiac illness and death

Results of a study in this week's issue of THE LANCET provide further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk. The study also emphasises the importance of early blood-pressure lowering after the start of treatment to reduce the risk of cardiovascular events such as heart attack and stroke.

17 Jun 2004

Harmless virus known as GBV-C slows the progression of HIV

Iowa City Veterans Affairs (VA) Medical Center and University of Iowa (UI) researchers have unlocked part of the mystery of how a harmless virus known as GBV-C slows the progression of HIV and prolongs survival for many patients.

17 Jun 2004

Further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk

Results of a study in this week’s issue of THE LANCET provide further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk. The study also emphasises the importance of early blood-pressure lowering after the start of treatment to reduce the risk of cardiovascular events such as heart attack and stroke.

17 Jun 2004

Marijuana/Cannabis causes transient schizophrenia-like symptoms

The principal active ingredient in marijuana causes transient schizophrenia-like symptoms ranging from suspiciousness and delusions to impairments in memory and attention, according to a Yale research study.

15 Jun 2004

Cancer drug gefitinib (Iressa) may be able to restore tamoxifen's anticancer activity

A new study has found a possible mechanism for tamoxifen resistance in breast cancer and provides evidence that another cancer drug--gefitinib (Iressa)--may be able to restore tamoxifen's anticancer activity.

15 Jun 2004

Gestational diabetes is a type of diabetes, or high blood sugar, that only pregnant women get

Gestational diabetes is a type of diabetes, or high blood sugar, that only pregnant women get. If a woman is found to have high blood sugar when she's pregnant, but she never had high blood sugar before, she has gestational diabetes.

15 Jun 2004

What causes polycystic ovary syndrome?

A woman finds herself with excessive facial hair, obesity, menstrual abnormalities, infertility, and enlarged ovaries may have polycystic ovary syndrome (PCOS), an unfortunate condition thought to be caused by excessive secretion by the ovaries of androgen, a hormone associated with male characteristics.

15 Jun 2004

African-American women less likely to survive breast cancer than white women

A new study led by investigators at Fred Hutchinson Cancer Research Center may help explain why African-American women with breast cancer are more likely to be diagnosed with advanced disease and are less likely to survive the disease than white women.

15 Jun 2004

Biologist has identified gene patterns that characterize a biologically distinct subtype of estrogen receptor negative breast tumor

University of North Carolina molecular biologist Charles Perou has identified the pattern of genes that characterize a biologically distinct subtype of estrogen receptor negative breast tumor.

14 Jun 2004

Topiramate may protect newborns from brain injury and long-term neurologic problems caused by excitotoxicity

An existing drug already approved by the FDA may protect newborns from brain injury and long-term neurologic problems caused by excitotoxicity, or over-activation of neurons, report two NIH-funded studies from Children's Hospital Boston.

14 Jun 2004

Body fat not always bad

With the threat of an obesity crisis looming, a study led by UCL researchers reveals today that fat tissue isn’t always the enemy. Reporting in the journal Science they show that a molecular signalling pathway in fat tissue is an important mediator in extending lifespan.

11 Jun 2004

New treatment significantly improves long-term outlook for breast cancer survivors

An updated analysis from an international clinical trial of the drug letrozole was presented on June 8, 2004 at the American Society of Clinical Oncology annual meeting in New Orleans.

11 Jun 2004

Project aimed at eliminating anthrax as a potential weapon for terrorists

La Trobe University scientists are using their own unique peptide 'library' containing a thousand million molecular sequences in a project aimed at eliminating anthrax as a potential weapon for terrorists.

10 Jun 2004

Gene that affects alcohol sensitivity

Since one of the basic risk factors for alcoholism is a tolerance to alcohol, researchers have long sought to understand the genetic differences among people that affect their sensitivity to alcohol. So far, scientists have met with little success.

9 Jun 2004

Genetic link between hormones and migraine

Director of the Genomics Research Centre Professor Lyn Griffiths and her team of researchers at Griffith University have identified a genetic link between hormones and migraine.

9 Jun 2004

Experimental human monoclonal antibody shows striking benefit in patients with advanced melanoma

Early testing of an experimental human monoclonal antibody showed a striking benefit in patients with advanced melanoma, say researchers at The University of Texas M. D. Anderson Cancer Center, who presented their findings at the annual meeting of the American Society of Clinical Oncology.

7 Jun 2004

Receptor News and Research

Exelixis files new drug application for a proprietary novel anticancer compound

Scientists use genetic engineering to work out how odors are encoded

European Commission has approved the use of Herceptin® (trastuzumab) in combination with Taxotere®

Drug for multiple sclerosis prevented disease development when tested on animal models

Valsartan may reduce cardiac illness and death

Harmless virus known as GBV-C slows the progression of HIV

Further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk

Marijuana/Cannabis causes transient schizophrenia-like symptoms

Cancer drug gefitinib (Iressa) may be able to restore tamoxifen's anticancer activity

Gestational diabetes is a type of diabetes, or high blood sugar, that only pregnant women get

What causes polycystic ovary syndrome?

African-American women less likely to survive breast cancer than white women

Biologist has identified gene patterns that characterize a biologically distinct subtype of estrogen receptor negative breast tumor

Topiramate may protect newborns from brain injury and long-term neurologic problems caused by excitotoxicity

Body fat not always bad

New treatment significantly improves long-term outlook for breast cancer survivors

Project aimed at eliminating anthrax as a potential weapon for terrorists

Gene that affects alcohol sensitivity

Genetic link between hormones and migraine

Experimental human monoclonal antibody shows striking benefit in patients with advanced melanoma

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