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Study suggests B-cell responses to booster vaccines are impeded by recent SARS-CoV-2 infection

Researchers investigated whether the time of booster vaccination relative to SARS-CoV-2 infection is a crucial determinant of the elicited immune response; in particular, the antibody and B-cell responses.

29 Sep 2022

Significant humoral immune evasion contributes to the emergence and rapid spread of Arg346-mutated BA.4 and BA.5 sublineages

=Researchers measured the neutralizing titers of plasma samples against the SARS-CoV-2 new variant of concern Omicron's sub-variants BA.4 and BA.5 with arginine (Arg)346 mutations.

29 Sep 2022

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

A new study focused on the immune system's Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.

28 Sep 2022

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

A new study showed that SARS-CoV-2 Spike N-glycosylation patterns, intracellular lectins, and the associated molecular chaperones play crucial roles in the viral-host-cell invasion and function.

28 Sep 2022

Live imaging and cellular barcoding reveal how new stem cells are vetted for quality

Using live imaging and cellular barcoding, researchers in the Stem Cell Program at Boston Children's Hospital have glimpsed how new stem cells -; in this case, blood stem cells -; are vetted for quality soon after they're born.

28 Sep 2022

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

A recent study designed immunogens to induce antibodies against SARS-CoV-2 variants.

28 Sep 2022

Q-LAAD: a dynamic, cost-effective rapid antigen test for detection of SARS-CoV-2

Researchers developed a high-throughput, rapid antigen SARS-CoV-2 spike protein detection test using allonamers, a new type of aptamers that carry out allosteric regulation instead of catalytic activity.

28 Sep 2022

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

A one-time test could predict which people hospitalized with COVID-19 are likely to worsen significantly during their stay, even if they were admitted with relatively mild symptoms, according to a study of more than 2,500 people headed by researchers at Stanford Medicine.

27 Sep 2022

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, primarily causes mild to moderate upper-respiratory tract illness. However, some individuals with COVID-19 develop severe infections and require hospital admission.

27 Sep 2022

New lab technique could spark a 'paradigm shift' in testing protein-based drugs

New Jersey Institute of Technology researchers have unveiled a new lab technique they say represents a "paradigm shift" in how pharmaceutical laboratories test and produce new protein-based drugs, such as therapeutic monoclonal antibodies being developed to treat a variety of diseases, from cancers to infectious diseases.

27 Sep 2022

Italian scientists investigate whether stranded cetaceans show evidence of SARS-CoV-2 infection

A new study examines SARS-CoV-2 infection in stranded cetaceans found dead along the Italian coast.

27 Sep 2022

Leducq Foundation awards $15 million to advance the understanding of atherosclerosis

The Leducq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it. Diseases linked to atherosclerosis are the leading cause of death in the United States.

27 Sep 2022

Vaccinating mothers during pregnancy may be an effective strategy to boost COVID antibodies in infants

Women with COVID in pregnancy who are subsequently vaccinated after recovery, but prior to delivery, are more likely to pass antibodies on to the child than similarly infected but unvaccinated mothers are.

27 Sep 2022

Specific N-glycans regulate the development and functional maturation of SARS-CoV-2 spike protein

If you're an avid reader of science news, you've probably heard of viral proteins such as the COVID-19 spike protein.

27 Sep 2022

The antibody response against SARS-CoV-2 in patients pre- and post-infusion with commercial intravenous immunoglobulin products

Researchers comparatively evaluated antibody responses against SARS-CoV-2 among immunodeficient individuals pre- and post-intravenous immunoglobulin product infusions.

27 Sep 2022

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia explored the molecular mechanisms of the pulmonary and cardiac complications caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using human stem-cell-derived cardiac and lung cells.

27 Sep 2022

COVID-19 can cause long-term lung damage to children and teens

In a recent study published in the Radiology journal, researchers in Germany assessed the pulmonary dysfunction observed after pediatric coronavirus disease 2019 (COVID-19).

27 Sep 2022

Review says dose of approved COVID-19 vaccines based on weak evidence

A recent study posted to the medRxiv* preprint server reviewed early-phase dose-finding trials to examine the study design, safety, and early antibody response data on approved coronavirus disease 2019 (COVID-19) vaccines and gain insights on design improvements for future candidate COVID-19 vaccine clinical trials.

26 Sep 2022

Study looks at boosting with variant-derived COVID vaccine

In a recent study posted to bioRxiv*, researchers at Washington University School of Medicine, St. Louis, demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine booster elicits robust germinal center (GC) B cell responses.

26 Sep 2022

Study characterizes immunological signature of SARS-CoV-2 infection in children

A recent study has demonstrated that the clinical severity of COVID-19 in children depends on the dynamics of immune response induced by SARS-CoV-2 infection.

26 Sep 2022

Antibodies News and Research

Study suggests B-cell responses to booster vaccines are impeded by recent SARS-CoV-2 infection

Significant humoral immune evasion contributes to the emergence and rapid spread of Arg346-mutated BA.4 and BA.5 sublineages

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

Live imaging and cellular barcoding reveal how new stem cells are vetted for quality

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

Q-LAAD: a dynamic, cost-effective rapid antigen test for detection of SARS-CoV-2

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

New lab technique could spark a 'paradigm shift' in testing protein-based drugs

Italian scientists investigate whether stranded cetaceans show evidence of SARS-CoV-2 infection

Leducq Foundation awards $15 million to advance the understanding of atherosclerosis

Vaccinating mothers during pregnancy may be an effective strategy to boost COVID antibodies in infants

Specific N-glycans regulate the development and functional maturation of SARS-CoV-2 spike protein

The antibody response against SARS-CoV-2 in patients pre- and post-infusion with commercial intravenous immunoglobulin products

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

COVID-19 can cause long-term lung damage to children and teens

Review says dose of approved COVID-19 vaccines based on weak evidence

Study looks at boosting with variant-derived COVID vaccine

Study characterizes immunological signature of SARS-CoV-2 infection in children

How to make hybridoma-based antibody discovery more efficient eBook

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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