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Scientists identify two genes involved in establishing neuronal circuits required for breathing

Scientists at NYU Langone Medical Center have identified two genes involved in establishing the neuronal circuits required for breathing. They report their findings in a study published in the December issue of Nature Neuroscience.

30 Nov 2012

Novartis to highlight key data from extensive oncology portfolio at SABCS and ASH meeting

Novartis will highlight more than 140 presentations on key data from its extensive oncology portfolio at the leading year-end scientific meetings devoted to hematology and breast cancer, demonstrating continued innovation in research and development efforts to advance the care of patients with cancer and rare diseases.

30 Nov 2012

Regorafenib phase III results strongly support use in GIST

Regorafenib is effective for patients with gastrointestinal stromal tumors who have failed to respond to treatment with imatinib and sunitinib, trial results show.

29 Nov 2012

Nasolabial lip reconstruction provides favorable functional, aesthetic outcomes

Lip reconstruction with the musculocutaneous nasolabial flap following lip resection achieves good functional and aesthetic outcomes, research suggests.

29 Nov 2012

Patient adherence predicts ankle surgery healing

Focusing on postoperative care may be the optimal way of reducing healing complications following ankle fracture surgery, say US researchers.

29 Nov 2012

Imaging window into future for brain injury patients

A model based on quantitative diffusion tensor imaging findings predicts outcomes after severe traumatic brain injury better than current methods, shows a multicenter study.

29 Nov 2012

Reoperation not reliable indicator for hernia recurrence

Using reoperation rates as the indicator for recurrence after ventral hernia repair may underestimate the true recurrence rate, according to Danish study findings.

29 Nov 2012

Study: Tdap vaccination safe for seniors

A new study of the safety of the tetanus-diphtheria-acellular pertussis (Tdap) vaccine supports the recommendation that those 65 and older get the vaccine to protect themselves and others, particularly young babies, from pertussis.

29 Nov 2012

Pharma companies improving access to medicines but lack oversight of outsourced clinical trials, analysis says

Pharmaceutical companies are showing "greater accountability in the boardroom today over access to medicines, with more openness, targets and investment in drugs relevant to the poor," but they "show no evidence that they adequately supervise the conduct of outsourced clinical drug trials, according to a new analysis released on Wednesday," the Financial Times reports.

29 Nov 2012

NovImmune commences NI-0101 Phase I clinical trial in arthritis

NovImmune SA initiated dosing in a Phase I clinical trial of NI-0101, a monoclonal antibody drug candidate targeting toll-like receptor-4 (TLR4).

29 Nov 2012

Bleeding risk modifies perioperative beta-blocker benefits

Perioperative use of beta blockers seems to be beneficial unless patients experience heavy bleeding, in which case it may be detrimental, say researchers.

28 Nov 2012

Hemorrhage risk ‘higher than reported’ for AF warfarin users

Real-world findings for atrial fibrillation patients using warfarin point to a significantly higher risk for hemorrhage than reported for clinical trials.

28 Nov 2012

Parainfluenza virus 5 may serve as foundation for next breakthrough in human vaccine development

Researchers at the University of Georgia have discovered that a virus commonly found in dogs may serve as the foundation for the next great breakthrough in human vaccine development.

28 Nov 2012

ABCA3 gene associated with respiratory distress syndrome in babies

Some infants are more susceptible to potentially life-threatening breathing problems after birth, and rare, inherited DNA differences may explain why, according to research at Washington University School of Medicine in St. Louis.

28 Nov 2012

Ultrasound puts emergency lines in the right place

Training emergency department staff in use of ultrasound to guide difficult peripheral intravenous catheter placement appears to reduce the unnecessary use of central venous lines, a study suggests.

27 Nov 2012

Simple measures halve ventilator-associated pneumonia

Adding a bundle of low-cost interventions to surveillance significantly reduces rates of ventilator-associated pneumonia in adult intensive care units in developing countries, shows an international study.

27 Nov 2012

New SARS-like virus detected in total of six people from Saudi Arabia, Qatar, WHO says

"A new virus from the same family as SARS which sparked a global alert in September has now killed two people in Saudi Arabia, and total cases there and in Qatar have reached six, the World Health Organization said" on Friday, Reuters reports.

27 Nov 2012

CLCA1 molecule plays a special role in the mucus pathway

Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of death in these conditions - excess mucus production.

26 Nov 2012

Tivantinib holds personalized therapy promise in HCC

Tivantinib is an effective second-line therapy for hepatocellular carcinoma patients whose tumors exhibit high MET receptor tyrosine kinase expression, indicate phase II study results.

26 Nov 2012

ICU use, outcomes vary globally

Intensive care unit use varies significantly between the USA and Europe, raising important questions about approaches to the critical care of patients with severe sepsis and septic shock, say researchers.

26 Nov 2012