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Common challenges facing drug development and reimbursement for rare diseases

Approximately 90% of rare diseases still have no effective treatments, despite regulators implementing expedited approval pathways for these indications.

25 Feb 2020

Researchers explore whether plaque identifying toothpaste could prevent heart attack, stroke

For decades, researchers have suggested a link between oral health and inflammatory diseases affecting the entire body -- in particular, heart attacks and strokes.

24 Feb 2020

Antifibrinolytic agent could be a treatment for bleeding stroke

A common medication that reduces bleeding could be a treatment for bleeding stroke, particularly if administered quickly, according to late breaking science presented today at the American Stroke Association's International Stroke Conference 2020.

23 Feb 2020

Secondary analysis reinforces safety of blood thinner

Treatment with the blood thinner apixaban was associated with a lower risk of bleeding, death and hospitalization compared with warfarin, regardless of history of prior stroke or blood clot, according to a secondary analysis presented as late breaking science today at the American Stroke Association's International Stroke Conference 2020.

23 Feb 2020

New drug offers hope for preserving brain cells for a time after stroke

After 50 years of research and the testing of over 1,000 drugs, there is new hope for preserving brain cells for a time after stroke.

21 Feb 2020

Spanish version of modified Story Memory Technique effective for Mexicans with MS

A team of researchers reported preliminary findings for efficacy of the Spanish version of the modified Story Memory Technique, a cognitive intervention developed at Kessler Foundation.

19 Feb 2020

Tart cherry juice concentrate helps improve endurance exercise performance, analysis finds

Montmorency tart cherry juice has gained a reputation as a recovery drink among elite and recreational exercisers, with research suggesting benefits for reducing strength loss and improving muscle recovery after intensive exercise.

19 Feb 2020

Combination therapy for pediatric low-grade gliomas shows promise in mice

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas.

17 Feb 2020

Drinking cocoa could relieve peripheral arterial disease

Someday, according to a new study, doctors might prescribe chocolate or cocoa to help patients with peripheral arterial disease to walk easier. The study published in February 2020 in the journal Circulation Research of the American Heart Association (AHA) reports a significant improvement in walking distance in patients following regular cocoa consumption.

16 Feb 2020

Cocoa consumption may improve walking performance in peripheral artery disease patients

Consumption of cocoa may improve walking performance for patients with peripheral artery disease, according to the results of a small, preliminary, phase II research trial published today in the American Heart Association's journal Circulation Research.

14 Feb 2020

Forgiveness combined with acetaminophen can alleviate social pain

Most everyone experiences the pain of social rejection at some point in their lives. It can be triggered by the end of a romantic relationship, losing a job or being excluded by friends.

14 Feb 2020

Kisspeptin can boost human attraction brain pathways, study shows

The researchers behind the early-stage work, published in JCI Insight, are exploring whether kisspeptin can ultimately be used to treat men with common psychosexual disorders - sexual problems which are psychological in origin such as low libido.

13 Feb 2020

Recent progress in TB diagnostics and prevention approaches offers hope for future

In September 2018, the National Institute of Allergy and Infectious Diseases, part of the NIH, issued its Strategic Plan for Tuberculosis Research, which outlined research priorities to reduce and ultimately end the burden of tuberculosis.

11 Feb 2020

Marijuana use increases false memories finds study

A new study published this week has revealed that the use of marijuana or cannabis can implant false memories. The study titled, "Cannabis increases susceptibility to false memory," was published in the latest issue of the journal Proceedings of the National Academy of Sciences.

11 Feb 2020

Depression treatment using AI, brain scans

Artificial intelligence (AI) may be a useful and even essential tool in selecting the best treatment for depression, according to a new study published in the journal Nature Biotechnology on February 2020.

10 Feb 2020

Study to evaluate safety of PrEP and dapivirine ring in pregnant women

A woman who is eight-months pregnant is the first participant to be enrolled into a study evaluating the safety and acceptability of two different HIV prevention approaches when used during pregnancy -- the monthly dapivirine vaginal ring, which is currently under regulatory review, and a daily antiretroviral (ARV) pill called Truvada, an approach already approved in several countries and commonly referred to as PrEP, short for pre-exposure prophylaxis.

10 Feb 2020

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

An international clinical trial evaluating whether two investigational drugs can slow memory loss and cognitive decline in people in the early stages of a rare, inherited form of Alzheimer's disease has yielded disappointing results, an initial analysis of the data has shown.

10 Feb 2020

New treatment effective at reversing the manifestations of thyroid eye disease

Patients with thyroid eye disease who used the minimally invasive insulin-like growth factor I blocking antibody, teprotumumab, experienced improvement in their symptoms, appearance and quality of life, according to a study recently published in the New England Journal of Medicine.

10 Feb 2020

New plant-based drug shown to help patients with head and neck cancers

In a UCLA-led phase I clinical trial, a new plant-based drug called APG-157 showed signs of helping patients fight oral and oropharyngeal cancers. These cancers are located in the head and the neck.

5 Feb 2020

Promising HIV vaccine fails in a large-scale clinical trial

The human immune deficiency virus (HIV) is an infectious disease that can lead to immunosuppression called acquired immunodeficiency syndrome (AIDS). For decades, scientists race to discover a vaccine that can help prevent the spread of the virus. The latest trial testing a new experimental vaccine in South Africa end in disappointment after deeming ineffective in preventing infection.

4 Feb 2020

Placebo News and Research

Common challenges facing drug development and reimbursement for rare diseases

Researchers explore whether plaque identifying toothpaste could prevent heart attack, stroke

Antifibrinolytic agent could be a treatment for bleeding stroke

Secondary analysis reinforces safety of blood thinner

New drug offers hope for preserving brain cells for a time after stroke

Spanish version of modified Story Memory Technique effective for Mexicans with MS

Tart cherry juice concentrate helps improve endurance exercise performance, analysis finds

Combination therapy for pediatric low-grade gliomas shows promise in mice

Drinking cocoa could relieve peripheral arterial disease

Cocoa consumption may improve walking performance in peripheral artery disease patients

Forgiveness combined with acetaminophen can alleviate social pain

Kisspeptin can boost human attraction brain pathways, study shows

Recent progress in TB diagnostics and prevention approaches offers hope for future

Marijuana use increases false memories finds study

Depression treatment using AI, brain scans

Study to evaluate safety of PrEP and dapivirine ring in pregnant women

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

New treatment effective at reversing the manifestations of thyroid eye disease

New plant-based drug shown to help patients with head and neck cancers

Promising HIV vaccine fails in a large-scale clinical trial

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