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New study to test novel psychedelic compound as potential treatment for alcohol use disorder

Modern mental health company Clerkenwell Health announced today that it is working with clinical-stage biotechnology company Beckley Psytech on a Phase IIa study investigating whether a novel psychedelic compound, combined with psychological support, could be an effective treatment for alcohol use disorder (AUD).

29 Mar 2024

An ActRIIA fusion protein got FDA approved for PAH treatment

On March 26th, the US FDA granted approval for Merck’s WINREVAIR™ (sotatercept-csrk), marking a significant milestone in pulmonary arterial hypertension (PAH) treatment. PAH, characterized by elevated blood pressure in the arteries connecting the heart and lungs, poses a grave risk of heart failure.

From Sino Biological Inc. 28 Mar 2024

AudioCure Pharma: Novel compound AC102 restores noise-induced hearing loss in preclinical models

A single application of the novel compound AC102 almost completely restores noise-induced hearing loss in preclinical models.

28 Mar 2024

Researchers discover key drivers behind follicular lymphoma's aggressive transformation

A team led by researchers at Weill Cornell Medicine has identified important drivers of the transformation of a type of blood cancer called follicular lymphoma from a slow-growing form to the aggressive form it takes in some patients.

28 Mar 2024

Sensory neurons play pivotal role in orchestrating tissue repair and regeneration

Researchers from Monash University and Osaka University have unveiled a groundbreaking discovery regarding the pivotal role of sensory neurons in orchestrating tissue repair and regeneration, offering significant promise for patients with poorly healing tissues and diabetes.

27 Mar 2024

Drug combination could hold new promise for treating colorectal cancers and other solid tumors

A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published today in Science Advances.

27 Mar 2024

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer's.

27 Mar 2024

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

A team of researchers from Columbia University Irving Medical Center and Columbia Engineering has been awarded up to a $38.95 million contract from the Advanced Research Projects Agency for Health (ARPA-H) to build a living knee replacement from biomaterials and human stem cells, including a patient's own cells.

26 Mar 2024

UC researchers open Phase 2 clinical trial to test new combination treatment for glioblastomas

A multidisciplinary team of University of Cincinnati Cancer Center researchers have opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas (GBM), the most deadly form of brain tumors.

26 Mar 2024

Ubiquigent and Debiopharm enter agreement to support USP1 inhibitor programme for Debio 0432

Project will be a demonstration of how Ubiquigent’s DUB-centric platform can support the development of DUB inhibitors all the way from discovery through to clinical development.

From Ubiquigent Limited 26 Mar 2024

Leveraging cancer therapies to combat tuberculosis

What could cancer teach us about tuberculosis? That's a question Meenal Datta has been chasing since she was a graduate student.

25 Mar 2024

Boosting butyrate-producing gut bacteria lowers hospitalization rates for infections

A study of two large European patient cohorts has found that for every 10% increase in butyrate-producing bacteria in a patient's gut, the risk of hospitalization for any infection falls by between 14 and 25% across two large national cohorts.

22 Mar 2024

Mount Sinai launches first study on high-resolution brain-computer interface

A multidisciplinary team of neurosurgeons and neuroscientists from the Icahn School of Medicine at Mount Sinai are the first in New York to study a new brain-computer interface that's engineered to map a large area of the brain's surface, in real time, at resolutions hundreds of times more detailed than typical arrays used in neurosurgical procedures.

22 Mar 2024

Branched chain amino acid supplementation speeds concussion recovery in adolescents

A new study in the peer-reviewed Journal of Neurotrauma found a significant reduction in total symptom score and faster return to physical activity among adolescents and young adults with concussion who were treated with branched chain amino acid (BCAA) supplementation.

21 Mar 2024

Researchers design new bioinformatics tool to identify chromosomal alterations in cancer cells

A team of the University of Barcelona and the Biomedical Research Institute of Barcelona (IRB Barcelona) has designed a new bioinformatics tool to identify the chromosomal alterations that are characteristic of cancer cells.

21 Mar 2024

Advancing precision personalized medicine for gastric cancer with 3D bioprinting

Gastric cancer ranks among the most widespread diseases in Asian populations, with South Koreans experiencing the third-highest incidence globally in 2020, as reported by the International Agency for Research on Cancer.

21 Mar 2024

NUS study reveals key mechanisms behind drug resistance in relapsed acute myeloid leukemia

Scientists from the National University of Singapore (NUS) have discovered that the evasion of apoptosis is a key driver of drug resistance in patients with relapsed acute myeloid leukaemia (AML), a type of aggressive blood cancer.

19 Mar 2024

Advanced hydrogel promotes GI wound healing

Gastrointestinal (GI) surgery, interventional screening procedures such as colonoscopies, and naturally occurring complications such as ulcers, can lead to adverse events, including internal bleeding, intestinal wall perforation, and leakage.

19 Mar 2024

New drug candidates show promise to reverse HIV immune evasion

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

19 Mar 2024

New fluid biomarker may one day detect ALS and FTD before symptoms appear

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.

18 Mar 2024

Preclinical News and Research

New study to test novel psychedelic compound as potential treatment for alcohol use disorder

An ActRIIA fusion protein got FDA approved for PAH treatment

AudioCure Pharma: Novel compound AC102 restores noise-induced hearing loss in preclinical models

Researchers discover key drivers behind follicular lymphoma's aggressive transformation

Sensory neurons play pivotal role in orchestrating tissue repair and regeneration

Drug combination could hold new promise for treating colorectal cancers and other solid tumors

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

UC researchers open Phase 2 clinical trial to test new combination treatment for glioblastomas

Ubiquigent and Debiopharm enter agreement to support USP1 inhibitor programme for Debio 0432

Leveraging cancer therapies to combat tuberculosis

Boosting butyrate-producing gut bacteria lowers hospitalization rates for infections

Mount Sinai launches first study on high-resolution brain-computer interface

Branched chain amino acid supplementation speeds concussion recovery in adolescents

Researchers design new bioinformatics tool to identify chromosomal alterations in cancer cells

Advancing precision personalized medicine for gastric cancer with 3D bioprinting

NUS study reveals key mechanisms behind drug resistance in relapsed acute myeloid leukemia

Advanced hydrogel promotes GI wound healing

New drug candidates show promise to reverse HIV immune evasion

New fluid biomarker may one day detect ALS and FTD before symptoms appear

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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