NanoFlowSizer FIDES: Real-time nanoparticle size characterization for high-turbidity applications

InProcess's FIDES can aid particle characterization for high-turbidity applications.

The NanoFlowSizer

• Exclusive technology
• Unique Spatially Resolved DLS technology
• Real-time analysis in highly turbid samples
• Measured non-invasively in any transparent container
• Strong PAT tool

The solution for

• LNP Manufacturing
• Emulsification and HPH Process Monitoring
• Active Pharmaceutical Ingredient Milling
• Crystallization and Polymerization
• Large particle detection (imaging) In-line Design of Experiments: formulation screening
• Aggregation Monitoring

Features and benefits

• Real-time, continuous data collection (<5 seconds)
• Particle size and size distribution
• Complete process customization; Lab, pilot, and manufacturing scale modules available
• XsperGo software is GMP-compliant and OPC-UA compatible
• Real-time monitoring that is economical and lowers operating expenses
• Lower chance of batch failures

Image Credit: InProcess-LSP 

“Integrating the NanoFlowSizer FIDES has significantly reduced batch failures in our vaccine production through precise inline monitoring.”

Image Credit: InProcess-LSP

Fides

Perfect for analyzing (in)organic and lipid nanoparticles

Hardware solutions:

• Tailored system setup for flow and offline analysis at small, medium, and large scales
• Online Micro Dilution (OMD): The solution for extremely high turbidities and concentrations
• Trolley-mounted systems;

Software solutions:

• PhaSR: The solution for very low particle size and low concentrations
• Large Particle Detection (LPD): Additional imaging capability

Image Credit: InProcess-LSP

System features

Source: InProcess-LSP

* Turbidity ranges are particle-type and solvent-dependent and need to be experimentally determined