NanoFlowSizer THALIA: High-sensitivity protein and nanoparticle analysis for low-concentration applications

InProcess introduces THALIA – the ideal analyzer for proteins and nanoparticles in low-concentration applications.

The NanoFlowSizer

• Proprietary technology
• Powerful PAT Tool
• Unique Spatially Resolved DLS Technology
• Non-invasive measurement in any transparent container
• High sensitivity in low concentrations

The solution for

• Stability Screening
• Protein Analysis for ADC, mAb, pAb, viruses
• Large particle detection (Imaging)
• Aggregation Monitoring
• In-line Design of Experiments: Formulation screening 

Features and benefits

• Continuous data collection in real-time (<5 sec)
• Fully customizable to specific processes; modules available for lab, pilot, and manufacturing scales
• Measurement of (very small) particle size and size distribution
• Capability to measure low-concentration materials
• Decreased risk of batch failures
• XsperGo software is GMP-compliant and OPC-UA compatible
• Affordable real-time monitoring to minimize operational expenses

Image Credit: InProcess-LSP 

“The THALIA system offers us a powerful tool for protein analysis, such as monoclonal antibodies (mAbs). It also allows precise monitoring of aggregation formation in our process.”

Image Credit: InProcess-LSP 

THALIA

Perfect for low concentrations and low nanometer range analysis

Image Credit: InProcess-LSP 

Software solutions:

• PhaSR: Enhanced Sensitivity in Analysis Range
• Large Particle Detection (LPD): Live Imaging of Particle Aggregation
• GMP Compliant and OPC-UA Compatible

Hardware solutions:

• Customized system configuration for small, medium, and large-scale scale flow and offline analysis
• Trolley-mounted systems

System features

Source: InProcess-LSP

* Turbidity ranges are particle-type and solvent-dependent and need to be experimentally determined