The NanoFlowSizer is an innovative Process Analytical Tool (PAT) for non-invasive, real-time nanoparticle characterization. Leveraging proprietary Spatially Resolved Dynamic Light Scattering (SR-DLS) technology, it delivers precise particle size distribution analysis across varying turbidity levels. Ideal for R&D, pilot, and full-scale manufacturing, this modular system integrates seamlessly inline, online, at-line, or offline to enhance process efficiency.
Key features
- Completely adaptable to manufacturing, pilot, and lab scales
- Nanoparticles are continuously measured in real-time while processing
- Non-invasive measurement in any kind of container, such as flow cells, vials, and syringes
- Flexibility in online, offline, at-line, and inline
- Size distribution and hydrodynamic diameter (D10, D50, D90, PDI)
- Suitable for extremely turbid materials
- Software (XsperGo) that complies with GMP and is compatible with OPC-UA
Why choose the NanoFlowSizer?
- Economical real-time surveillance
- Advanced process monitoring
- A special solution for Process Analytical Technology (PAT)
- Extremely quick measurement (less than 5 seconds per data point)
- Effective data administration
- Lower chance of batch failures
Technical specifications
Source: InProcess Instruments BV
| Parameter |
Specifications |
| Measurement Principle |
Spatially Resolved DLS (SR-DLS) |
| Particle Size Range |
15 nm - 5000 nm |
| Turbidity Compatibility |
Low to very high |
| Measurement Modes |
Inline, online, at-line, offline |
| Flow Rate |
Up to 250 L/hr |
| Data Collection |
Real-time, <5 sec per data point |
| Supported Particles |
LNPs, (in)organic particles, Milled API, protein, mAb, pAb, ADC |
| Software |
XsperGo (GMP features, PhaSR) |
| Probe Unit Dimensions |
25 x 35 x 10 cm |
Industry applications
- Pharmaceuticals and Biotech – LNPs, proteins, antibodies, APIs
- Advanced Manufacturing – Continuous flow production
- Nanomaterials – Organic and inorganic nanoparticles
- Chemical and Food Industries – Emulsions, suspensions, dispersions
What InProcess' users say
“We were searching for an instrument that could perform non-invasive measurements, such as analysis directly within syringes. With the NanoFlowSizer, this is now a reality.”
Image Credit: InProcess-LSP