Biochemistry

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Chimeric tagging technique offers new hope in the fight against drug-resistant infections

A new study has developed an innovative approach to combat antibiotic-resistant bacteria by tagging them with a chimeric agent that activates the immune system towards them.

15 Nov 2024

Researchers make progress toward inhalable mRNA medicines

Most people don't enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA (mRNA), that can be sprayed and inhaled.

14 Nov 2024

Novel compound BHB-Phe could offer new approach to weight loss

Researchers at Baylor College of Medicine, Stanford University School of Medicine and collaborating institutions report in the journal Cell the discovery of BHB-Phe, a novel compound produced by the body that regulates appetite and body weight through interactions with neurons in the brain.

12 Nov 2024

Researchers unlock method for mass producing herbal medicine in yeast

Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations.

12 Nov 2024

CHiTA assay identifies functional twister ribozymes

The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA -; a single-stranded molecule similar in many ways to DNA -; like some modern viruses. This is because, like DNA, RNA can carry genetic information, but, like a protein, it can also act as an enzyme, initiating or accelerating reactions.

5 Nov 2024

Discovery of multidomain enzyme enhances drug development potential

Pharmaceutical scientists from the National University of Singapore (NUS) have identified and characterized a unique multidomain enzyme capable of catalyzing two distinct types of reactions, both vital for making drug molecules.

29 Oct 2024

Researchers uncover key mechanisms of CRISPR gene editing

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy.

28 Oct 2024

Novel class of encrypted peptides offers hope against drug-resistant bacteria

In a significant advance against the growing threat of antibiotic-resistant bacteria, researchers have identified a novel class of antimicrobial agents known as encrypted peptides, which may expand the immune system's arsenal of tools to fight infection.

28 Oct 2024

Bioactive peptides from Chlorella vulgaris for therapeutic applications

Chlorella vulgaris is a green, photosynthetic microalga in the phylum Chlorophyta. The goal of our study was to perform a bioinformatics analysis of Photosystem I P700 chlorophyll a apoprotein A2, one of its photosynthesis-related proteins, and to hunt for potent bioactive peptides.

27 Oct 2024

Novel findings on GRB2 and SOS1 could pave the way for cancer treatments

Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass signals from membrane receptors to nuclei.

26 Oct 2024

Southwest Research Institute breaks ground on new clinical supply facility

Southwest Research Institute broke ground today on a new 21,000-square-foot Clinical Supply Facility to support government and industry clients with integrated pharmaceutical and bioengineering research and development.

23 Oct 2024

Structural biology reveals secrets of DEV phage infection

The viruses that infect bacteria are the most abundant biological entities on the planet. For example, a recent simple study of 92 showerheads and 36 toothbrushes from American bathrooms found more than 600 types of bacterial viruses, commonly called bacteriophages or phages.

22 Oct 2024