Biochemistry

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Multi-signal processing guide RNAs: A new frontier in gene regulation

Multi-signal processing guide RNAs: A new frontier in gene regulation

Guides typically assist tourists with directions, but the experience could be greatly enhanced if they offered personalized services tailored to individual interests.

22 Jul 2024

Ginseng genome unlocks secrets of medicinal benefits

Ginseng genome unlocks secrets of medicinal benefits

A landmark study has successfully decoded the complete ginseng genome, unveiling the genetic mechanisms that govern saponin biosynthesis. This detailed genetic map illuminates the evolutionary and metabolic pathways of Panax ginseng, a staple in traditional medicine. This pivotal discovery promises to drive forward breeding initiatives and augment the plant's medicinal qualities, unlocking new possibilities for therapeutic applications.

19 Jul 2024

New insights into modified nucleoside synthesis

New insights into modified nucleoside synthesis

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system.

19 Jul 2024

Discovery of over 1,000 undetected proteins in metabolite samples

Discovery of over 1,000 undetected proteins in metabolite samples

Van Andel Institute scientists have identified more than 1,000 previously undetected proteins in common metabolite samples, which persist despite extraction methods designed to weed them out.

18 Jul 2024

Innovative approaches in polymer nanoparticle synthesis for RNA therapeutics

Innovative approaches in polymer nanoparticle synthesis for RNA therapeutics

RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses.

15 Jul 2024

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Dispen3D is setting new standards in single-cell biology, enabling researchers to conduct high-precision experiments that drive advancements in drug discovery, personalized medicine, and regenerative therapies.

From SEED Biosciences 12 Jul 2024

Enzymatic RNA synthesis paves the way for sustainable therapeutics

Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network.

10 Jul 2024

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium.

9 Jul 2024

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide.

4 Jul 2024

Research could help drug developers improve the safety profiles of medications

Research could help drug developers improve the safety profiles of medications

Research from the University of British Columbia, MIT, and the University of Michigan could help drug developers improve the safety profiles of medications and reduce side effects.

3 Jul 2024

GCARDTI: Advancing drug-target interaction prediction with hybrid graph learning

GCARDTI: Advancing drug-target interaction prediction with hybrid graph learning

The identification of drug-target Interactions (DTIs) represents a pivotal link in the process of drug development and design.

2 Jul 2024

Key transcription factor enhances anthocyanin production in wounded grapevines

Key transcription factor enhances anthocyanin production in wounded grapevines

A recent study sheds light on the biochemical response of grapevines to wounding stress. It reveals that the transcription factor VvWRKY5 is a key regulator that enhances anthocyanin production, which serves as a protective mechanism for the plant.

2 Jul 2024

New weakness found in antibiotic-resistant Pseudomonas aeruginosa

New weakness found in antibiotic-resistant Pseudomonas aeruginosa

Antibiotic resistant bacteria are experts in evolving new strategies to avoid being killed by antibiotics.

1 Jul 2024

MICROBIOMES4SOY: Harnessing microbiome innovations for sustainable food systems

MICROBIOMES4SOY: Harnessing microbiome innovations for sustainable food systems

MICROBIOMES4SOY responds to the urgent call on World Microbiome Day to transition to healthier, more environmentally friendly, plant-based diets.

27 Jun 2024

Using microbial community-scale metabolic modeling approach for precision nutrition

Using microbial community-scale metabolic modeling approach for precision nutrition

Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more.

24 Jun 2024

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides like strychnine and anticancer drugs such as vinblastine and minovincine.

24 Jun 2024

Transforming drug discovery with AI

Transforming drug discovery with AI

A new AI-powered program will allow researchers to level up their drug discovery efforts.

21 Jun 2024

Using deep learning to design synthetic soluble versions of cell membrane proteins

Using deep learning to design synthetic soluble versions of cell membrane proteins

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

21 Jun 2024

Artificial variants of Withanolides act highly specifically against leukemia cells

Artificial variants of Withanolides act highly specifically against leukemia cells

Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells.

21 Jun 2024

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