Biochemistry

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Study uncovers how rice blast fungus uses its own cell wall to launch an attack

In response to environmental changes and nutrient starvation, cells are known to undergo extreme alterations. This includes switching from one type to another (“differentiation”) and changes in metabolic pathways (“metabolic switching”).

14 Jan 2020

How SpatialOMx is Delivering New Insights into Disease Research

An interview with Shannon Cornett Ph.D, discussing the use of MALDI-guided spatial molecular analysis for biomarker discovery.

From Bruker Life Sciences Mass Spectrometry 14 Jan 2020

A controlled phage therapy to target drug-resistant pathogens

The fight against drug-resistant pathogens remains an intense one. While the Centers for Disease Control's 2019 "biggest threats" report reveals an overall decrease in drug-resistant microbe-related deaths as compared to its previous report (2013) the agency also cautions that new forms of drug-resistant pathogens are still emerging.

13 Jan 2020

Study shows how insects adjust their physiological responses to gravity

If you jump out of bed too quickly, you might feel a bit light-headed. That's because when you're lying down, gravity causes your blood to pool in the lower parts of your body rather than in your brain.

13 Jan 2020

New study sheds light on storage and retrieval of hardwired long-term memory

Storing and retrieving memories is among the most important tasks our intricate brains must perform, yet how that happens at a molecular level remains incompletely understood.

13 Jan 2020

Researchers use computer simulations to study how neuroreceptors respond to nicotine

As smokers know all too well, nicotine is highly addictive. It's hard to quit smoking, a habit that claims the lives of more than seven million people each year.

13 Jan 2020

New mathematical model can efficiently model the expression of enzymes in living cells

All living things are made of carbon, and sugars, e.g. glucose, are a very common source of it. Consequently, most cells are good at eating sugars, using enzymes to digest them through a series of chemical reactions that transform the initial sugar into a variety of cell components, including amino acids, DNA building blocks, and fats.

13 Jan 2020

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

Common genetic defect in prostate cancer associated with worse prognosis

Like security screening to make sure nothing harmful makes its way into a crowded area, cells in the human body use checkpoints to control their growth and prevent harmful mutations from making their way into new cell populations and causing trouble.

9 Jan 2020

Insect leaf-wounding produces healthier organic fruit

Texas A&M AgriLife Research scientists found benefits of insect leaf-wounding in fruit and vegetable production. Stress responses created in the fruits and vegetables initiated an increase in antioxidant compounds prior to harvest, making them healthier for human consumption.

9 Jan 2020

Scientists discover how bacterial evolution of antibiotic arsenals is providing new drug blueprints

Scientists from Trinity College Dublin have discovered that two very different species of bacteria have evolved distinct, powerful antibiotic arsenals for use in the war against their bacterial neighbors.

9 Jan 2020

New screening platform helped scientists to discover drug-like compounds

A sophisticated new screening platform developed by scientists at Scripps Research has enabled them to discover a set of drug-like compounds, including an ingredient found in sore throat lozenges, that may powerfully protect brain cells from dangerous stresses found in Alzheimer's and other neurodegenerative diseases.

9 Jan 2020

Researchers report first structural model for key enzyme associated with inherited eye diseases

Researchers at the University of New Hampshire have reported the first structural model for a key enzyme, and its activating protein, that can play a role in some genetically inherited eye diseases like retinitis pigmentosa and night blindness.

8 Jan 2020

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Scientists from Trinity College Dublin have discovered both how TB puts the brakes on our immune engines and how we can kick-start those engines back into gear - providing hope that improved treatment options could soon be on the horizon.

8 Jan 2020

Research adds definitive evidence about how the body's earliest immune cells are formed

One day the advance could lead to a patient's own skin cells being used to produce new cells for cancer immunotherapy or to test autoimmune disease interventions.

8 Jan 2020

Researchers study new immunogenic properties of already existing anti-cancer drugs

The world scientific community is waging a difficult and prolonged war on cancer. New research in the field of immunogenic cell death can extend the area of drugs application and ensure patients' protection from relapse after therapy.

3 Jan 2020

Structure of most lethal toxin produced by C. difficile bacteria identified

Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The

2 Jan 2020

Measuring glycans in samples of antibodies

When Lorna De Leoz invited laboratories to participate in her glycomics study, she hoped for 20 responses. Instead, she was deluged by emails from around the world.

2 Jan 2020

Researchers move closer to identifying leukemic stem cells

Acute myeloid leukemia is the most common type of leukemia in adults. It is characterized by the pathological expansion of immature cells (myeloblasts) that invade the bone marrow and expand into the blood, affecting the production of the rest of the healthy cells.

2 Jan 2020

Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils

Ariel Louwrier discusses the development of pre-formed tau and alpha-synuclein fibrils for research into Alzheimer's and Parkinson's disease.

From StressMarq Biosciences Inc. 2 Jan 2020

Biochemistry

Study uncovers how rice blast fungus uses its own cell wall to launch an attack

How SpatialOMx is Delivering New Insights into Disease Research

A controlled phage therapy to target drug-resistant pathogens

Study shows how insects adjust their physiological responses to gravity

New study sheds light on storage and retrieval of hardwired long-term memory

Researchers use computer simulations to study how neuroreceptors respond to nicotine

New mathematical model can efficiently model the expression of enzymes in living cells

New molecular probe senses the state of proteome in live cells

Common genetic defect in prostate cancer associated with worse prognosis

Insect leaf-wounding produces healthier organic fruit

Scientists discover how bacterial evolution of antibiotic arsenals is providing new drug blueprints

New screening platform helped scientists to discover drug-like compounds

Researchers report first structural model for key enzyme associated with inherited eye diseases

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Research adds definitive evidence about how the body's earliest immune cells are formed

Researchers study new immunogenic properties of already existing anti-cancer drugs

Structure of most lethal toxin produced by C. difficile bacteria identified

Measuring glycans in samples of antibodies

Researchers move closer to identifying leukemic stem cells

Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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