Cell Biology

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New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Salk research in yeast leads to serendipitous finding about hypomyelinating leukodystrophy

Studying the fundamental aspects of biology can sometimes lead to unexpected findings that directly relate to human disease. In one of the latest examples of scientific serendipity, researchers from the Salk Institute found that an important quality control mechanism in baker's yeast is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children.

17 Sep 2018

Replacement bisphenols cause reproductive defects in lab mice

Twenty years ago, researchers made the accidental discovery that the now infamous plastics ingredient known as bisphenol A or BPA had inadvertently leached out of plastic cages used to house female mice in the lab, causing a sudden increase in chromosomally abnormal eggs in the animals.

14 Sep 2018

People display clear signs of confirmation bias when judging on sensory input

People have a tendency to interpret new information in a way that supports their pre-existing beliefs, a phenomenon known as confirmation bias.

14 Sep 2018

Study could pave way for new therapies to reverse aging in human cells

Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age.

14 Sep 2018

Researchers describe mechanism that sets stage for fate decision of T cells

After a pathogen infects the body, the immune system responds with a remarkable -- and remarkably complicated -- cascade of events.

14 Sep 2018

Blood serum induces spontaneous movement and growth of skin cells

What happens to skin cells when they are confronted with blood? A team of researchers from Oslo University Hospital, led by Emma Lång and Stig Ove Bøe, performed experiments on blood-deprived cells that were subsequently exposed to blood serum.

13 Sep 2018

Aging may have originated at the very beginning of life, says study

A new USC Dornsife study indicates that aging may have originated at the very beginning of the evolution of life, at the same time as the evolution of the first genes.

13 Sep 2018

Bacteria in the gut found to produce electricity

Researchers have discovered hundreds of bacterial species, including those in the human gut, that can generate electricity.

13 Sep 2018

Study provides complete picture of HPV virus-head and neck cancer connections

Human papillomavirus is widely known to cause nearly all cases of cervical cancer. However, you might not know that HPV also causes 70 percent of oropharyngeal cancer, a subset of head and neck cancers that affect the mouth, tongue, and tonsils.

12 Sep 2018

Mitochondrial pathway found to be involved in breast cancer

Researchers have discovered a molecular pathway that controls the movement of mitochondria within breast cancer cells and influences invasiveness.

12 Sep 2018

Targeting pathway controlling mitochondria may reduce cancer invasiveness

Targeting a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy.

12 Sep 2018

Study finds overlapping copy number variations in Japanese patients with autism and schizophrenia

Common genetic variants may underlie autism spectrum disorder and schizophrenia across human populations, according to a study appearing September 11th in the journal Cell Reports.

12 Sep 2018

Differences in mitochondrial DNA determine severity of heart disease caused by nDNA mutation

Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation.

12 Sep 2018

Research shows how poisonous proteins of Clostridium difficile penetrate intestinal cells

Treating bacterial infections with antibiotics often kills intestinal flora, leading to diarrhoea and inflammation of the gut.

12 Sep 2018

Penn receives NIH grant to create Center for Sub-Cellular Genomics

The five-year, $10.5 million grant from the NIH is the first CEGS awarded to Penn and funds the creation of the Center for Sub-Cellular Genomics.

12 Sep 2018

Scientists develop first DNA-based test for predicting risk of leukemia relapse

A group of Canadian and Korean scientists and physicians have developed the first DNA-based test that allows them to tell which patients will relapse after receiving chemotherapy and a bone marrow transplant, for their acute myeloid leukemia, or AML.

11 Sep 2018

How 'bad' bacteria gain an upper hand in the human gut

A study has revealed that the bacterium C. difficile gains a competitive advantage over protective bacteria in the human gut by producing para-cresol.

11 Sep 2018

Improve reliability, accuracy of drug discovery process with new 3D cell analysis technology

Olympus Corporation today announced the U.S.-only launch of a new 3D cell analysis technology with ability to accurately analyze 3D cell cultures down to the nuclei, improving the reliability and accuracy of the entire drug discovery process, from compound selection to animal experimentation and clinical trials in humans.

From Evident Corporation - Life Sciences 11 Sep 2018

Molecular switches are far more complex than previously assumed

The GTPases constitute a very large protein family, whose members are involved in the control of cell growth, transport of molecules, synthesis of other proteins, etc. Despite the many functions of the GTPases, they follow a common cyclic pattern.

10 Sep 2018