Cell Biology

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Tweaking nuclear pores could provide new avenue to battle against cancer

If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of nuclear pores.

19 Sep 2018

Researchers use CRISPR screen to reveal new targets in squamous cell carcinomas

A little p63 goes a long way in embryonic development - and flaws in p63 can result in birth defects like cleft palette, fused fingers or even missing limbs.

18 Sep 2018

Logos Biosystems releases new electrophoretic tissue clearing system with twice the features in half the space

Logos Biosystems has released the latest system for electrophoretic tissue clearing, the X-CLARITY™ Tissue Clearing System II. The new system has been upgraded with new features that make it streamlined, easier to use and more intuitive.

From Logos Biosystems 18 Sep 2018

Researchers find way to map mysterious content of non-coding RNA

Researchers from the University of North Carolina have found a way of categorising long non-coding RNAs (lnc-RNAs) by their probable function.

18 Sep 2018

Zika virus vaccine shows promise for treatment of fatal glioblastoma

An international team of researchers has successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice.

18 Sep 2018

Purifying Proteins from Mammalian Cell Culture

In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function of the therapeutic protein.

From Sartorius 18 Sep 2018

Researchers analyze how exposure to silver nanoparticles affects zebrafish

Silver nanoparticles are increasingly being used in consumer products, such as clothing and personal care products, in the medical and pharmaceutical industry, and in the food industry.

18 Sep 2018

Key signaling molecule that helps stem cells make healthy bone declines as we age

With age, expression of a small molecule that can silence others goes way up while a key signaling molecule that helps stem cells make healthy bone goes down, scientists report.

18 Sep 2018

Researchers identify key step in how plant cells respond to pathogens

Just like humans, plants have an immune system that helps them fight off infections. Plant immunity has some important differences: they don't make antibodies and can't fight off the same bug more quickly months or years later.

18 Sep 2018

Researchers discover how plants harness microbes in soil to get nutrients

A Rutgers-led team has discovered how plants harness microbes in soil to get nutrients, a process that could be exploited to boost crop growth, fight weeds and slash the use of polluting fertilizers and herbicides.

18 Sep 2018

New research on sperm quality updates advice for couples trying to conceive

Could doctors at fertility clinics be giving men bad advice? Dr. Da Li and Dr. XiuXia Wang, who are clinician-researchers at the Center for Reproductive Medicine of Shengjing Hospital in Shenyang in northeast China, think so.

17 Sep 2018

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, Germany, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell.

17 Sep 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Salk research in yeast leads to serendipitous finding about hypomyelinating leukodystrophy

Studying the fundamental aspects of biology can sometimes lead to unexpected findings that directly relate to human disease. In one of the latest examples of scientific serendipity, researchers from the Salk Institute found that an important quality control mechanism in baker's yeast is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children.

17 Sep 2018

Replacement bisphenols cause reproductive defects in lab mice

Twenty years ago, researchers made the accidental discovery that the now infamous plastics ingredient known as bisphenol A or BPA had inadvertently leached out of plastic cages used to house female mice in the lab, causing a sudden increase in chromosomally abnormal eggs in the animals.

14 Sep 2018