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Durata completes target enrollment in dalbavancin Phase 3 trials for abSSSI

Durata Therapeutics today announced that it has completed its target enrollment for DISCOVER 1 ("Dalbavancin for Infections of the Skin COmpared to Vancomycin at an Early Response"), one of two ongoing, global, Phase 3 clinical trials of Durata's lead product candidate, dalbavancin, under investigation for the treatment of acute bacterial skin and skin structure infections (abSSSI).

7 Sep 2012

Heavy rainfall worsening cholera outbreaks in Sierra Leone, Guinea

"Heavy rainfall is accelerating the spread of cholera in Sierra Leone and Guinea, where existing health risks such as poor hygiene practices, unsafe water sources and improper waste management are believed to have triggered the disease which has killed 327 people and infected more than 17,400 in both countries since February," IRIN reports.

6 Sep 2012

Telaprevir offers advantages in patients with chronic hepatitis C infection of genotype 1

The drug telaprevir has been available for treatment of chronic hepatitis C infection of genotype 1 since autumn 2011. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether telaprevir offers an added benefit compared with the present standard therapy.

6 Sep 2012

New cell screening method can identify potential anti-influenza drugs

Medical Systems Virology group at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki, together with its national and international collaborators, developed a new cell screening method that can be used to identify potential anti-influenza drugs.

6 Sep 2012

Cholera vaccine offers herd immunity, study from Zanzibar shows

"Cholera vaccine gives indirect protection to unvaccinated people in communities where a substantial fraction of the population gets the vaccine," according to a study from the island of Zanzibar in East Africa, published in the Lancet on Tuesday, NPR's "Shots" blog reports.

6 Sep 2012

Blog examines results of independent AMFm evaluation draft report

"In mid-July, ... the near-final draft of the independent evaluation of the Affordable Medicines Facility -- Malaria (AMFm) was released," Victoria Fan, a research fellow at the Center for Global Development (CGD), and Heather Lanthorn, a doctoral candidate at Harvard School of Public Health, write in this post in the center's "Global Health Policy" blog.

6 Sep 2012

WHO releases dengue strategy report, sets goal of cutting related deaths in half by 2020

"Saying dengue virus infections and deaths have mushroomed in recent years, the World Health Organization (WHO) recently released a strategy report that sets a goal of cutting deaths in half and reducing cases by 25 percent over the next eight years," CIDRAP reports.

6 Sep 2012

Community-based approach to improving sanitation, hygiene practices in Vietnam, Cambodia

In this post in the ONE Blog, John Anner, president of the East Meets West Foundation, discusses how the foundation is helping to improve sanitation and hygiene practices among poor populations.

6 Sep 2012

PlusNews examines recently approved grants under Global Fund's Transitional Funding Mechanism

PlusNews examines the recently approved grants under the Global Fund to Fight AIDS, Tuberculosis and Malaria's Transitional Funding Mechanism (TFM), stating, "Last week, the Fund announced that 45 new grant applications, from countries such as Burundi, Malawi and Swaziland, have been approved under the TFM."

6 Sep 2012

Pakistan official says progress made in vaccinating thousands of children against polio in tribal area

"Pakistan Tuesday claimed progress in vaccinating thousands of children against polio in a tribal area bordering Afghanistan which had been inaccessible due to unrest for about three years," Agence France-Presse reports.

6 Sep 2012

FDA continues review of Salix’s Crofelemer new drug application

Napo Pharmaceuticals, Inc. was informed today that the Food and Drug Administration is continuing its review of the new drug application seeking approval of crofelemer for the treatment of chronic diarrhea in people living with HIV/AIDS on anti-retroviral therapy.

6 Sep 2012

Developing countries NGO delegation to Global Fund submits report highlighting challenges, recommendations

The Center for Global Health Policy's "Science Speaks" blog discusses a report by the developing countries NGO delegation to the Global Fund to Fight AIDS, Tuberculosis and Malaria, submitted recently to the Global Fund Secretariat.

6 Sep 2012

Alnylam announces complete results from ALN-RSV01 Phase IIb trial on RSV infection

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today complete results from its Phase IIb trial with ALN-RSV01 for the treatment of respiratory syncytial virus (RSV) infection in lung transplant patients.

6 Sep 2012

Janssen receives FDA Priority Review for bedaquiline NDA to treat MDR-TB

Janssen Research & Development, LLC (Janssen) announced today that the U.S. Food and Drug Administration (FDA) has granted Priority Review to the New Drug Application (NDA) for bedaquiline (TMC207) to treat pulmonary, multi-drug resistant tuberculosis (MDR-TB) in adults as part of combination therapy.

6 Sep 2012

People need to protect themselves against West Nile virus

As this year's threat from the West Nile virus continues, one infectious diseases expert at the University of Alabama at Birmingham says a vaccine is not in our near future, so people need to protect themselves.

5 Sep 2012

U.S. outbreaks of Dengue, West Nile demonstrate need for U.S investment in neglected diseases

The "growing public health problems" of West Nile and dengue viruses in the U.S. can "serve as opportunities to pull the U.S. squarely into the global fight against these mosquito-borne viruses," a Bloomberg View editorial states.

5 Sep 2012

U.N. SG warns withdraw of aid groups from Haiti leaves country struggling with cholera epidemic

U.N. Secretary-General Ban Ki-moon "warned on Friday that Haiti was struggling to cope with a cholera epidemic that has killed thousands and deteriorating conditions in tent camps as aid groups withdraw from the impoverished country due to a lack of funding," Reuters reports.

5 Sep 2012

Strong antiviral antibody response observed in oral administration of Flucide

NanoViricides, Inc. announced today that anti-influenza drug candidates under its FluCide program, when given orally, led to strong antiviral antibody response. The antibody response with Oral administration was stronger than that with IV administration and was substantially greater than that observed with oseltamivir.

5 Sep 2012

S. African, S. Korean research team developing smartphone HIV testing device, application

Researchers from South Africa and South Korea are developing a smartphone-based device and application able to "photograph and analyze blood samples in areas far from laboratories to diagnose HIV and even measure the health of [patients'] immune systems," Agence France-Presse reports.

5 Sep 2012

Medivir strengthens hepatitis C platform

Medivir AB, announced today that it has acquired preclinical research stage assets from Novadex Pharmaceuticals AB. The acquisition includes intellectual property and prodrug technologies in order to further strengthen Medivir's hepatitis C platform and know how.

5 Sep 2012

Disease/Infection News

Durata completes target enrollment in dalbavancin Phase 3 trials for abSSSI

Heavy rainfall worsening cholera outbreaks in Sierra Leone, Guinea

Telaprevir offers advantages in patients with chronic hepatitis C infection of genotype 1

New cell screening method can identify potential anti-influenza drugs

Cholera vaccine offers herd immunity, study from Zanzibar shows

Blog examines results of independent AMFm evaluation draft report

WHO releases dengue strategy report, sets goal of cutting related deaths in half by 2020

Community-based approach to improving sanitation, hygiene practices in Vietnam, Cambodia

PlusNews examines recently approved grants under Global Fund's Transitional Funding Mechanism

Pakistan official says progress made in vaccinating thousands of children against polio in tribal area

FDA continues review of Salix’s Crofelemer new drug application

Developing countries NGO delegation to Global Fund submits report highlighting challenges, recommendations

Alnylam announces complete results from ALN-RSV01 Phase IIb trial on RSV infection

Janssen receives FDA Priority Review for bedaquiline NDA to treat MDR-TB

People need to protect themselves against West Nile virus

U.S. outbreaks of Dengue, West Nile demonstrate need for U.S investment in neglected diseases

U.N. SG warns withdraw of aid groups from Haiti leaves country struggling with cholera epidemic

Strong antiviral antibody response observed in oral administration of Flucide

S. African, S. Korean research team developing smartphone HIV testing device, application

Medivir strengthens hepatitis C platform

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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