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Scientists examine kids’ unique immune systems as more fall victim to covid

Eighteen months into the covid-19 pandemic, with the delta variant fueling a massive resurgence of disease, many hospitals are hitting a heartbreaking new low. They're now losing babies to the coronavirus.

17 Sep 2021

Sex defining factors influence expression of ACE2 and other SARS-CoV-2 machinery

Results from this study provided evidence for the hypothesis that sex-defining factors influence the expression of ACE2 and other SARS CoV-2 machinery.

17 Sep 2021

Adenovirus-based nanoparticle vaccine elicits potent SARS-CoV-2 neutralizing antibody response

In a study available on the preprint server medRxiv*, researchers have created a vaccine designed to overcome issues associated with attenuated-virus vaccines.

17 Sep 2021

New protocol for donning and doffing personal protective equipment during home visits

Researchers describe a protocol for donning and doffing personal protective equipment in home settings for health care professionals who must interact with patients potentially infected with COVID-19. This protocol addresses gaps in COVID-19 related guidelines, specifically the process of donning and doffing PPE during home visits while supplementing PPE guidelines and protocols. To create the protocol, the researchers used an interactive, rapid-prototyping approach.

17 Sep 2021

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

For the last seven years, researchers at the Lewis Katz School of Medicine at Temple University have been developing and refining CRISPR-based gene-editing technology for the treatment of human immunodeficiency virus type 1 (HIV) infection.

17 Sep 2021

COVID-19 variants keep getting better at traveling through the air, study shows

Results of a new study led by the University of Maryland School of Public Health show that people infected with the virus that causes COVID-19 exhale infectious virus in their breath – and those infected with the Alpha variant (the dominant strain circulating at the time this study was conducted) put 43 to 100 times more virus into the air than people infected with the original strains of the virus.

17 Sep 2021

Three doses of inactivated BBIBP-CorV SARS-CoV-2 vaccine induce robust B and T cell responses

To investigate the immune memory sustainability of SARS-CoV-2-specific B cells and T cells, stimulated by the inactivated vaccine, and the potential need for a third booster dose in healthcare workers (HCWs), a non-randomized trial was undertaken by researchers at Sun Yat-sen University in Guangzhou, China. the research is posted online on the medRxiv* preprint server.

17 Sep 2021

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

A new study discusses the vaccination response in elderly who were vaccinated with one dose of the Pfizer vaccine 15 months after contracting COVID-19.

16 Sep 2021

How effective is the Johnson & Johnson COVID-19 vaccine?

A new study demonstrates the real-world efficacy of this vaccine, its stability over time, as well as its efficacy against the SARS-CoV-2 Delta variant.

16 Sep 2021

Antiviral compound RG10 acts via intracellular SARS-CoV-2-ER dynamics

A new study describes a small molecule referred to as RG10 that may have potent antiviral activity against SARS-CoV-2 in human cells.

16 Sep 2021

Neutralizing monoclonal antibodies provide Fc receptor-independent SARS-CoV-2 protection in Hamsters

A study published in the journal mBio analyzes the capacity of the neutralizing MAb 2B04 to protect different antibody titers.

16 Sep 2021

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

In a study published on the preprint server medRxiv*, scientists studying the SARS-CoV-2 genome have identified a region linked with the disease severity.

16 Sep 2021

Researchers examine the persistent effects of COVID-19 on vascular function of young adults

In a first-of-its-kind study, researchers have examined the persistent effects of SARS-CoV-2 infection on the vascular function of otherwise healthy young adults. The research, published in the American Journal of Physiology-Heart and Circulatory Physiology, was chosen as an APSselect article for September.

16 Sep 2021

Pediatric SARS-CoV-2 infections usually mild, says study

A new study in the journal BMC Pediatrics describes the clinical phenotypes and outcomes in a thousand children who developed COVID-19.

16 Sep 2021

COVID-19 and the gut-lung axis

A new study explores the hypothesis that stimulation of the gut could be responsible for the lung inflammation seen in COVID-19, triggered by SARS-CoV-2.

16 Sep 2021

Live oral SARS-CoV-2 vaccine provides partial protection in Rhesus Macaques

A new study describes the partial protection against respiratory infection with SARS-CoV-2 following gut inoculation with a live attenuated virus.

16 Sep 2021

IL-1-Ra autoantibodies observed in high frequency in children with PIMS/MIS-C

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection typically affects children only mildly, multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS) is a serious but rare complication occurring after infection.

16 Sep 2021

Rockefeller saliva test turns out to be easier and safer to administer than conventional COVID tests

In the early days of the pandemic, with commercial COVID tests in short supply, Rockefeller's Robert B. Darnell developed an in-house assay to identify positive cases within the Rockefeller community.

16 Sep 2021

New modeling on efficacy of BioNTech-Pfizer's SARS-CoV-2 vaccine against variants

In order to address these issues, scientists from Xitific LTD and IDEAPharma in the UK proposed a novel approach to the framework of immune correlates, built upon the previous research. The framework formulated by the authors was developed for the mRNA-based vaccinations but could be applied to the other variations.

16 Sep 2021

Therapeutic potential of clinical-grade ACE2 for blocking SARS-CoV-2 variants

According to new research by an international team of scientists, all SARS-CoV-2 variants, including variants of concern (VOC) Alpha, Beta, Gamma, and Delta, exhibit enhanced affinity toward recombinant human soluble ACE2.

16 Sep 2021

Disease/Infection News

Scientists examine kids’ unique immune systems as more fall victim to covid

Sex defining factors influence expression of ACE2 and other SARS-CoV-2 machinery

Adenovirus-based nanoparticle vaccine elicits potent SARS-CoV-2 neutralizing antibody response

New protocol for donning and doffing personal protective equipment during home visits

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

COVID-19 variants keep getting better at traveling through the air, study shows

Three doses of inactivated BBIBP-CorV SARS-CoV-2 vaccine induce robust B and T cell responses

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

How effective is the Johnson & Johnson COVID-19 vaccine?

Antiviral compound RG10 acts via intracellular SARS-CoV-2-ER dynamics

Neutralizing monoclonal antibodies provide Fc receptor-independent SARS-CoV-2 protection in Hamsters

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

Researchers examine the persistent effects of COVID-19 on vascular function of young adults

Pediatric SARS-CoV-2 infections usually mild, says study

COVID-19 and the gut-lung axis

Live oral SARS-CoV-2 vaccine provides partial protection in Rhesus Macaques

IL-1-Ra autoantibodies observed in high frequency in children with PIMS/MIS-C

Rockefeller saliva test turns out to be easier and safer to administer than conventional COVID tests

New modeling on efficacy of BioNTech-Pfizer's SARS-CoV-2 vaccine against variants

Therapeutic potential of clinical-grade ACE2 for blocking SARS-CoV-2 variants

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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