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The SARS-CoV-2 virus and its vaccines pose unique challenges

Iranian researchers recently provided a review of the attempts made to develop safe SARS-CoV-2 vaccines. The researchers outlined potential challenges and concerns, including disease enhancement, virus mutation, and public acceptability. Their work is published in the journal Immunological Investigations.

18 Jun 2021

Medieval plague victims were buried with considerable care and attention, shows study

In the mid-14th century Europe was devastated by a major pandemic - the Black Death - which killed between 40 and 60 per cent of the population. Later waves of plague then continued to strike regularly over several centuries.

18 Jun 2021

Alarming COVID study indicates long-term loss of gray matter and other brain tissue

In a research paper recently uploaded to the preprint server medRxiv* by Prof. Gwenaëlle Douaud et al. (June 15th, 2021), participants that had taken part in a brain study prior to the onset of the COVID-19 pandemic were invited back for a series of follow-up tests, revealing significant losses of grey matter surrounding the olfactory and gustatory system in those that had been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 Jun 2021

Indian WHO study examines COVID-19 susceptibility in children versus adults

Now, a group of researchers from India have explored this concept due to the lack of solid evidence and have undertaken a community and population-based serosurveillance study for the coronavirus infection under the World Health Organisation (WHO) Unity umbrella. In this study, participants older than two years old were compared to older adults in terms of seropositivity.

17 Jun 2021

Cinnamon compound could be useful supplement to dexamethasone in COVID-19 treatment

Researchers in Germany and the United States have conducted a study showing that supplementing dexamethasone treatment with Ceylon cinnamon in cases of coronavirus disease 2019 (COVID-19) may allow dexamethasone to be administered at lower doses, thereby avoiding the side effects that occur with high doses of the steroid.

17 Jun 2021

Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response

Researchers reporting on findings from the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial in the UK are recommending that any therapeutic use of REGEN-COV may be best restricted to individuals without detectable antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Jun 2021

Research may lead to rapid, accurate, point-of-care testing for COVID

A team of scientists headed by SANKEN (The Institute of Scientific and Industrial Research) at Osaka University demonstrated that single virus particles passing through a nanopore could be accurately identified using machine learning.

17 Jun 2021

Unequal hospital quality associated with higher COVID-19 death rate for Black patients

The COVID-19 death rate for Black patients would be 10 percent lower if they had access to the same hospitals as white patients, a new study shows.

17 Jun 2021

Study validates accuracy of new molecular test for tuberculosis diagnosis

The 'Xpert Ultra' molecular test has a greater capacity than its predecessor ('Xpert MTB/RIF') in detecting tuberculosis cases, either passively (i.e. people who attend the hospital with disease symptoms) or actively (searching for possible cases in the community among contacts of cases).

17 Jun 2021

The role of natural killer cells in fight against viral infections including SARS-CoV-2

In an effort to further understand the role of NK cells in combatting COVID-19, a group of researchers explored NK cells in acute viral infections, citing flavivirus and influenza virus infections as examples.

17 Jun 2021

New insight into SARS-CoV-2 mRNA vaccine breakthrough infections

In the current study, vaccine breakthrough infections were noted in 24 people who had previously received COVID-19 vaccines.

17 Jun 2021

Reconstituted mRNA Covid-19 vaccines can be safely transported

Researchers from the Hospital del Mar and Pompeu Fabra University have confirmed that messenger RNA vaccines pre-prepared in syringes for their administration can be transported by road for up to three hours.

17 Jun 2021

Neighborhood disadvantage related to increased COVID-19 infections and mortality

New York City neighborhoods that had higher levels of socioeconomic disadvantage experienced more COVID-19 infections and deaths, according to Mount Sinai scientists who created a neighborhood-level COVID-19 inequity index.

17 Jun 2021

How stable are mRNA vaccines under continuous movement?

Researchers tested reconstituted COVID-19 mRNA vaccines under different movement conditions and found that a moderate continuous movement does not damage the mRNA, which may increase the possibility of transporting reconstituted vaccine over a few hundred kilometers.

17 Jun 2021

Novel ferritin nanoparticle vaccine candidate effective against SARS-CoV-2 variants in preclinical trials

A team of scientists from the United States has recently evaluated the efficacy of a ferritin nanoparticle-formulated, SARS-CoV-2 spike-based vaccine against newly emerged Variants of Concern (VOCs).

17 Jun 2021

Could type III interferons be used as a SARS-CoV-2 therapeutic?

Researchers have found that both type I and type III interferons can inhibit SARS-CoV-2 infection in human intestinal cells, but type III interferons can act faster and for a longer period, making them suitable for potential therapeutics.

17 Jun 2021

Could wastewater epidemiology help track the circulation of SARS-CoV-2 variants?

In a new study, released as a preprint on the medRxiv* server, researchers from Germany, Italy and Netherlands demonstrated the utility of integrating genomic and wastewater based epidemiology (WBE) to provide unprecedented insight into the abundance of SARS-CoV-2 and the profile of the mutations associated with the VOCs (i.e., B.1.1.7, B.1.351, P.1, and B.1.617.2) in the wastewater samples.

17 Jun 2021

Mouse-adapted SARS-CoV-2 and simian adenovirus vector advance COVID-19 vaccine research

A new preprint recently released on the bioRxiv* server describes the immunogenicity and protective potential of a novel adenovirus SARS-CoV-2 vaccine candidate against a form of the virus adapted to cause severe disease in mice. The findings show that this provides a useful mouse model for the study of new vaccines, in addition to demonstrating the protective efficacy of the current rhesus adenovirus vaccine candidate RhAd52.

17 Jun 2021

AI ECG as a novel noninvasive approach to diagnosing cardiac injury in COVID-19 patients

A recent study discusses the efficacy of an AI-enhanced ECG technique that has been used to diagnose left ventricular dysfunction in COVID-19 patients.

17 Jun 2021

What impacts public compliance with COVID-19 restrictions?

New research by scientists at Switzerland's Institute for Environmental Decisions reports that risk perception and public acceptance of NPIs depends on both worldview and levels of social trust. The study also found that, paradoxically, when the number of cases decreased in the period between the first and second waves, public willingness to comply with these measures fell.

17 Jun 2021

Disease/Infection News

The SARS-CoV-2 virus and its vaccines pose unique challenges

Medieval plague victims were buried with considerable care and attention, shows study

Alarming COVID study indicates long-term loss of gray matter and other brain tissue

Indian WHO study examines COVID-19 susceptibility in children versus adults

Cinnamon compound could be useful supplement to dexamethasone in COVID-19 treatment

Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response

Research may lead to rapid, accurate, point-of-care testing for COVID

Unequal hospital quality associated with higher COVID-19 death rate for Black patients

Study validates accuracy of new molecular test for tuberculosis diagnosis

The role of natural killer cells in fight against viral infections including SARS-CoV-2

New insight into SARS-CoV-2 mRNA vaccine breakthrough infections

Reconstituted mRNA Covid-19 vaccines can be safely transported

Neighborhood disadvantage related to increased COVID-19 infections and mortality

How stable are mRNA vaccines under continuous movement?

Novel ferritin nanoparticle vaccine candidate effective against SARS-CoV-2 variants in preclinical trials

Could type III interferons be used as a SARS-CoV-2 therapeutic?

Could wastewater epidemiology help track the circulation of SARS-CoV-2 variants?

Mouse-adapted SARS-CoV-2 and simian adenovirus vector advance COVID-19 vaccine research

AI ECG as a novel noninvasive approach to diagnosing cardiac injury in COVID-19 patients

What impacts public compliance with COVID-19 restrictions?

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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