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Largescale antibody testing could lower the scale of COVID-19 pandemic

Research from Queen's University Belfast suggests that largescale antibody testing could lower social activity and thus contagion of COVID-19 (Coronavirus).

23 Feb 2021

Research predicts which mammal species can spread SARS-CoV-2

Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts.

23 Feb 2021

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

A randomized, placebo-controlled Phase 1 clinical trial of two monoclonal antibodies (mAbs) directed against the coronavirus that causes Middle East respiratory syndrome (MERS) found that they were well tolerated and generally safe when administered simultaneously to healthy adults.

23 Feb 2021

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

A paper recently uploaded to the preprint server bioRxiv by researchers at Chapman University in California (Feb 22nd, 2021) utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants for affinity with the angiotensin-converting enzyme 2 (ACE2) receptor and monoclonal antibodies REG10987 and REG10933.

23 Feb 2021

Innate immune system overreacts in patients with severe COVID-19

In patients with severe COVID-19, the innate immune system overreacts. This overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients.

23 Feb 2021

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

A new research paper recently uploaded to the preprint server bioRxiv by Jesse D. Bloom et al. (22nd Feb 2021) aims to map all of the currently circulating SARS-CoV-2 lineages with resistance towards LY-CoV555 and LY-CoV016, and document the specific mutations that confer resistance, ultimately suggesting that future monoclonal antibody cocktails should target a more diverse range of epitopes.

23 Feb 2021

GSK-3 inhibitors show promise in treating coronavirus infections

Researchers in the United States have suggested a new approach to treating infection with coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

23 Feb 2021

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others.

23 Feb 2021

New rapid diagnostic tests can differentiate between COVID-19 variants and multiple viruses

University of Minnesota Medical School researchers have developed two new rapid diagnostic tests for COVID-19 - one to detect COVID-19 variants and one to help differentiate with other illnesses that have COVID-19-like symptoms.

23 Feb 2021

Researchers develop models to predict epidemics of yellow fever, other mosquito-borne diseases

Yellow fever was the first human disease to have a licensed vaccine and has long been considered important to an understanding of how epidemics happen and should be combated.

23 Feb 2021

MUSC physician wins $9.9 million contract to run trials for the Tuberculosis Trials Consortium

Susan Dorman, M.D., an infectious disease physician at the Medical University of South Carolina, was recently awarded a 10-year, $9.9 million contract by the Centers for Disease Control and Prevention to run trials for the Tuberculosis Trials Consortium.

23 Feb 2021

'Phage therapy' helps treat mice infected with multidrug-resistant Klebsiella pneumoniae

Using viruses instead of antibiotics to tame troublesome drug-resistant bacteria is a promising strategy, known as bacteriophage or "phage therapy."

23 Feb 2021

Covid strikes clergy as they comfort pandemic’s sick and dying

The Rev. Jose Luis Garayoa survived typhoid fever, malaria, a kidnapping and the Ebola crisis as a missionary in Sierra Leone, only to die of Covid-19 after tending to the people of his Texas church who were sick from the virus and the grieving family members of those who died.

23 Feb 2021

Researchers develop nanoceutical mask fabric that prevents SARS-CoV-2 transmission

Researchers at S N Bose National Centre for Basic Sciences in West Bengal found that a nanoceutical fabric, which is comfortable, washable, and anti-microbial, can prevent the transmission of SARS-CoV-2.

23 Feb 2021

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Scientists at the University of Salzburg and Pantec Biosolutions AG have developed a laser-facilitated epicutaneous immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The model has induced angiotensin-converting enzyme 2 (ACE2) blocking antibodies in mice.

23 Feb 2021

Incidence of cardiometabolic and pulmonary events in UK has lowered due to COVID-19

A team of researchers from the University of Oxford, the London School of Hygiene and Tropical Medicine and other institutions recently analyzed extensive data collected by NHS England to reveal any association between SARS-CoV-2 infection and cardiometabolic or respiratory events.

23 Feb 2021

Disease/Infection News

Largescale antibody testing could lower the scale of COVID-19 pandemic

Research predicts which mammal species can spread SARS-CoV-2

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

Innate immune system overreacts in patients with severe COVID-19

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

GSK-3 inhibitors show promise in treating coronavirus infections

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

New rapid diagnostic tests can differentiate between COVID-19 variants and multiple viruses

Researchers develop models to predict epidemics of yellow fever, other mosquito-borne diseases

MUSC physician wins $9.9 million contract to run trials for the Tuberculosis Trials Consortium

'Phage therapy' helps treat mice infected with multidrug-resistant Klebsiella pneumoniae

Covid strikes clergy as they comfort pandemic’s sick and dying

Researchers develop nanoceutical mask fabric that prevents SARS-CoV-2 transmission

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Incidence of cardiometabolic and pulmonary events in UK has lowered due to COVID-19

How effective has Israel’s SARS-CoV-2 testing and vaccination campaign been against the UK variant?

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Countries with older populations have higher SARS-CoV-2 infections and deaths, says study

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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