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Inhibitors to target SARS-CoV-2 viral protein display strong antiviral activity in transgenic mouse model

Inhibitors based on approved drugs and designed to disrupt the SARS-CoV-2 viral protein Mpro display strong antiviral activity both in vitro and in a transgenic mouse model, a new study reports.

18 Feb 2021

Immune response to SARS-CoV-2 may be limited by a set of genes

Neutralizing antibodies develop within two weeks of a SARS-CoV-2 infection, but their durability and intensity can vary by individual, prompting concerns about the prospects of long-lasting immunity and efficacy of COVID-19 vaccines.

18 Feb 2021

Zambia study casts doubt on the assumption that COVID-19 skipped Africa

A new study concluding out of Lusaka, Zambia last summer has found that as many as 19% (almost 1 in 5) of recently-deceased people tested positive for COVID-19.

18 Feb 2021

USDA, FDA highlight no credible evidence of COVID-19 transmission through food or food packaging

After more than a year since the coronavirus disease 2019 (COVID-19) outbreak was declared a global health emergency, the U.S. Department of Agriculture, the U.S. Food and Drug Administration and the U.S. Centers for Disease Control and Prevention continue to underscore that there is no credible evidence of food or food packaging associated with or as a likely source of viral transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19.

18 Feb 2021

Study examines to what extent surgical site infection rates correlate with surveillance quality audits

The incidence of surgical site infections after an operation is an important quality indicator for hospitals.

18 Feb 2021

Changes in drinking and smoking during England’s first COVID-19 lockdown

The worldwide spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 infection in early 2020 prompted many nations to close their borders and institute mandatory lockdowns. While lockdowns abruptly stopped daily life, researchers from the University College London and the University of Sheffield found drug-seeking behaviors did not.

18 Feb 2021

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines

The mapping of O-glycosites requires instruments that can support electron transfer dissociation (ETD) fragmentation. In a new study published on the bioRxiv preprint server, researchers report their results on whether O-glycosylation patterns affect immunogens for vaccine development.

18 Feb 2021

Study: COVID-19 rates fall faster in richer countries

Richer countries were more likely to see rates of COVID-19 fall faster during the first wave of the pandemic, according to new research published in the journal Frontiers in Public Health.

18 Feb 2021

Could measles virus vectors be used for a new COVID-19 vaccine?

A research team at the Institut Pasteur in France describes the successful development of such a vaccine utilizing a measles virus vector.

18 Feb 2021

Restricting testing to 'classic triad' of symptoms may have missed some COVID-19 cases

Extending the symptoms that trigger a PCR test for COVID-19 could help detect around a third more cases of the disease.

18 Feb 2021

Study reveals extremely low detection of SARS-CoV-2 on surfaces in oncology facilities

Researchers from Rutgers Cancer Institute of New Jersey, the state's only National Cancer Institute-designated Comprehensive Cancer Center, evaluated the frequency of SARS-CoV-2, the virus that causes COVID-19, on various environmental surfaces in outpatient and inpatient hematology/oncology settings located within Rutgers Cancer Institute and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility.

18 Feb 2021

Clinical trial launched to analyze bovine-derived immunoglobulins for preventing COVID-19 side effects

The Hospital del Mar Medical Research Institute (IMIM), Hospital del Mar, the University of California-Davis and the University of Texas have launched a clinical trial to analyze how useful a food supplement can be for preventing the worst side effects of COVID-19.

18 Feb 2021

How has 3D printing come to the aid of healthcare during the COVID-19 pandemic?

In the study, published in the journal Emergent Materials, the researchers identified the role of 3D printing in COVID-19. During the pandemic, over 100 various 3D printable PPE designs have been used.

18 Feb 2021

A glycan controls how SARS-CoV-2’s spike protein opens, study finds

Using simulations, a team of researchers in the U.S. found that the glycan at position N343 of the SARS-CoV-2 spike protein’s receptor-binding domain (RBD) helps in its opening. A mechanism that aids its binding to the host cell receptor.

18 Feb 2021

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

A team of scientists from Australia and Brazil recently investigated the involvement of endothelial cells in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

18 Feb 2021

Researchers evaluate frequency of SARS-CoV-2 in hematology/oncology settings

18 Feb 2021

SARS-CoV-2 D614G mutation associated with lower antibody binding

The onset of the COVID-19 pandemic has brought about an international effort to uncover the biology of its causative agent, SARS-CoV-2, and to develop effective and safe antivirals to contain and treat the infection. A new study by a team of researchers in France and Sweden discusses one such study, exploring the relative immunogenicity of the three main structural proteins of the virus.

18 Feb 2021

How have COVID-19 pandemic school closures impacted the health of children globally?

A new study by researchers in the US and the UK explores the damage caused by school closures to educational progress, health, and well-being in children and young people globally.

18 Feb 2021

Are antibody cocktails the key to COVID-19 treatment?

News-Medical speaks to Dr. Natalia Freund about her latest research into COVID-19, and how most people are capable of producing neutralizing antibodies against the virus.

18 Feb 2021

New diagnostic platform can rapidly measure COVID-19-related biomarkers

The Wyss Institute for Biologically Inspired Engineering at Harvard University and GBS Inc., a subsidiary of The iQ Group Global, announce that they will collaborate to validate and de-risk a specific and sensitive COVID-19 diagnostic that would integrate the Institute's eRapid technology with the company's proprietary transistor sensor technology to enable simultaneous electrochemical sensing of multiple biomarkers related to SARS-CoV-2 infection in point-of-care COVID-19 diagnostic applications.

18 Feb 2021

Disease/Infection News

Inhibitors to target SARS-CoV-2 viral protein display strong antiviral activity in transgenic mouse model

Immune response to SARS-CoV-2 may be limited by a set of genes

Zambia study casts doubt on the assumption that COVID-19 skipped Africa

USDA, FDA highlight no credible evidence of COVID-19 transmission through food or food packaging

Study examines to what extent surgical site infection rates correlate with surveillance quality audits

Changes in drinking and smoking during England’s first COVID-19 lockdown

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines

Study: COVID-19 rates fall faster in richer countries

Could measles virus vectors be used for a new COVID-19 vaccine?

Restricting testing to 'classic triad' of symptoms may have missed some COVID-19 cases

Study reveals extremely low detection of SARS-CoV-2 on surfaces in oncology facilities

Clinical trial launched to analyze bovine-derived immunoglobulins for preventing COVID-19 side effects

How has 3D printing come to the aid of healthcare during the COVID-19 pandemic?

A glycan controls how SARS-CoV-2’s spike protein opens, study finds

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

Researchers evaluate frequency of SARS-CoV-2 in hematology/oncology settings

SARS-CoV-2 D614G mutation associated with lower antibody binding

How have COVID-19 pandemic school closures impacted the health of children globally?

Are antibody cocktails the key to COVID-19 treatment?

New diagnostic platform can rapidly measure COVID-19-related biomarkers

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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