Drug Discovery & Pharmaceuticals

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Alzheimer’s-in-a-dish model made better with microfluidic system

Researchers from Massachusetts have used a microfluidic device to incorporate neuroinflammation into the Alzheimer's-in-a-dish model for drug discovery.

31 Jul 2018

Researchers investigate new treatment that is effective against recurrent breast cancers

What do one in five breast cancers have in common? Large amounts of a protein called HER2 (or human epidermal growth factor receptor 2).

30 Jul 2018

Researchers discover how breast cells prevent cancer invasion

Researchers have shown that the cell layer surrounding breast milk ducts reaches out and engulfs cancerous cells to stop their spread.

30 Jul 2018

Computational platform predicts how to convert one cell type into another

Researchers have developed a computational platform that predicts how one subtype of cells can be converted into another subtype.

30 Jul 2018

Researchers discover novel antibiotic from leaf of common weed

Researchers working on an SNSF project have discovered novel, antibiotically active chemical substances in a previously rarely explored site: the leaf of a common field weed.

27 Jul 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

New drug discovery system allows scientists to target ‘undruggable’ enzymes

A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly "undruggable".

27 Jul 2018

Scientists discover gene that predicts arthritis severity

Scientists have discovered a new gene that is associated with disease severity in rheumatoid arthritis. HIP1 produces an inflammatory molecule which drives RA.

26 Jul 2018

New applications for high-throughput flow cytometry in drug discovery

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry in drug discovery.

24 Jul 2018

Discovery about how malaria moves could lead to new therapies

Researchers have made an important discovery about how Plasmodium falciparum (the parasite that causes malaria) is able to evade capture by the immune system.

23 Jul 2018

Top AI companies join hands to discover novel drugs for DMD

Insilico Medicine a leader in artificial intelligence for drug discovery, biomarker development and aging research, announced a research collaboration agreement with A2A Pharmaceuticals, Inc. A2A is a biotechnology company headquartered in New York and focused on development of novel drugs for unmet needs in oncology, drug resistant bacterial infections, and other life threatening diseases.

20 Jul 2018

Scientists discover protein regulator of myelin production

Scientists have made an important discovery about the role of a protein called PRMT5 in the production of myelin.

19 Jul 2018

Biophysicists use infrared sensor as new method for drug discovery

Using an infrared sensor, biophysicists at Ruhr-Universität Bochum have succeeded in analyzing quickly and easily which active agents affect the structure of proteins and how long that effect lasts.

19 Jul 2018

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

In a new SLAS Discovery article, Helen Yu and a team of researchers at Gilead Sciences, Inc. present a time-resolved fluorescence resonance energy transfer-based Bruton's tyrosine kinase occupancy assay that can measure target engagement in peripheral blood mononuclear cells and in lymph-node and bone-marrow samples.

17 Jul 2018

New molecule shows great promise for future treatment of many cancers

A new molecule designed by University of Adelaide researchers shows great promise for future treatment of many cancers.

17 Jul 2018

New class of chemical compounds has potential for treating Zika virus and RSV

A new and promising class of chemical compounds has major potential for treating Zika virus and respiratory syncytial virus, or RSV, according to a new study by University of Alberta scientists. The next step is to develop a drug.

12 Jul 2018

Stem cell study brings scientists closer to understanding schistosomiasis

Scientists have made an important discovery that could lead to the development of new treatments for schistosomiasis, a common parasitic disease.

10 Jul 2018

Fluorescent zebrafish genes provide clues about neuroblastoma

Researchers have created transgenic zebrafish that could help them understand how neuroblastoma, a common pediatric cancer, develops.

10 Jul 2018

Machine-learning model automates design of new molecules to accelerate drug development

Designing new molecules for pharmaceuticals is primarily a manual, time-consuming process that's prone to error. But MIT researchers have now taken a step toward fully automating the design process, which could drastically speed things up -- and produce better results.

9 Jul 2018