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Investigational new drug may be safe for patients with mild cognitive impairment, dementia

A small, preliminary study of an investigational new drug being studied for mild cognitive impairment and mild dementia associated with Alzheimer's disease suggests it is safe and may be associated with improvements in executive function, thinking and memory skills.

31 Mar 2022

Therapeutic antibodies against filoviruses including Ebola and Marburg

Researchers discuss the development and structural characterization of therapeutic monoclonal antibodies targeting the surface glycoprotein of filoviruses.

31 Mar 2022

NIH-sponsored trial of second COVID-19 booster shots begins enrolling adult participants

A Phase 2 clinical trial evaluating various additional COVID-19 booster shots has begun enrolling adult participants in the United States.

31 Mar 2022

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

Scientists urge African leaders to demand fair licensing following clinical trials of an HIV vaccine candidate.

30 Mar 2022

A ferritin nanoparticle candidate vaccine for COVID

In a recent study published on the bioRxiv* preprint server, the immunogenicity, and effectiveness of SARS-CoV-2 spike ferritin nanoparticle (SpFN) adjuvanted with aluminum hydroxide (AlOH3) or Army Liposomal Formulation QS-21 (ALFQ) in a cynomolgus macaque (CM) COVID-19 model was evaluated.

30 Mar 2022

How malaria drugs could play a part in treating chemotherapy-resistant head and neck cancers

In this interview, we speak to Kirill Kiselyov, Ph.D, and Umamaheswar Duvvuri, M.D, Ph.D, from the University of Pittsburgh, about their latest research into hydroxychloroquine, a drug widely used to prevent and treat malaria, as a potential treatment for head and neck cancers.

28 Mar 2022

New trial examines the effectiveness of a two-pronged immunotherapy for glioblastomas

A new clinical trial at the University of Cincinnati is studying the effectiveness of a new two-pronged immunotherapy treatment procedure to treat the most aggressive and deadly type of brain tumors, called glioblastomas. Originating from healthy brain cells, glioblastomas can form in any area of the brain.

25 Mar 2022

Hydrocortisone does not prevent bronchopulmonary dysplasia in preterm infants

Hydrocortisone is no more effective than placebo at preventing damage that can result from oxygen and ventilator therapy necessary to keep preterm infants alive, according to research funded by the National Institutes of Health.

23 Mar 2022

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

A team of clinical investigators at the Icahn School of Medicine at Mount Sinai has announced the launch of a Phase 1, open-label, placebo-controlled study to evaluate the safety and immunogenicity of an egg-based COVID-19 vaccine in healthy, vaccinated adults who have never been infected with COVID-19.

21 Mar 2022

Trial reveals effectiveness of axi-cel as first-line treatment for high-risk lymphoma

Results from the ZUMA-12 trial led by researchers at The University of Texas MD Anderson Cancer Center showed that first-line treatment with axicabtagene ciloleucel (axi-cel), a chimeric antigen receptor (CAR) T cell therapy, achieved a high rate of complete response in patients with high-risk large B-cell lymphoma (LBCL).

21 Mar 2022

Trial shows safety and immunogenicity of immunotherapy with chemoradiation in cervical cancer patients

A Phase I/Ib trial conducted by the National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group NRG Oncology, NRG-GY017, concluded that the addition of the immunotherapy drug atezolizumab prior to and concurrently given with chemoradiation (CRT) treatment was safe for women with node-positive, locally advanced cervical cancer.

19 Mar 2022

HRR mutational status associated with survival outcomes in recurrent platinum-sensitive ovarian cancer

Results of a biomarker analysis of the NRG Oncology NRG-GY004 trial were presented at a Seminal Session during the Society for Gynecologic Oncology's (SGO) Annual Meeting on Women's Cancer in March 2022.

19 Mar 2022

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

A combination therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in 75% of patients with recurrent or persistent estrogen receptor- (ER-) positive endometrial cancer, results from a recent clinical trial show.

19 Mar 2022

University of Kentucky begins world’s first clinical trial for LATE

The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.

17 Mar 2022

New trial finds signs of preventive cardiovascular effects for cocoa flavanols

The first large-scale trial to test the long-term effects of a cocoa flavanol supplement to prevent cardiovascular disease offers promising signals that cocoa flavanols could have protective cardiovascular effects.

16 Mar 2022

New Phase 1 clinical trial of mRNA HIV vaccine enrolls first participant

The first 12 study participants have been enrolled in a new Phase 1 clinical trial using the messenger ribonucleic acid (mRNA) vaccine technology developed by Moderna.

14 Mar 2022

NIH launches Phase 1 clinical trial evaluating three experimental mRNA HIV vaccines

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a Phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved COVID-19 vaccines.

14 Mar 2022

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

A study led by researchers from The University of Texas MD Anderson Cancer Center showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer.

10 Mar 2022

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

10 Mar 2022

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

The new drug nirsevimab showed 74.5 percent efficacy against medically attended lower respiratory tract infections caused by respiratory syncytial virus (RSV) in healthy infants, according to an international, randomized, placebo-controlled phase 3 clinical trial published in the New England Journal of Medicine.

9 Mar 2022

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Drug Trial News

Investigational new drug may be safe for patients with mild cognitive impairment, dementia

Therapeutic antibodies against filoviruses including Ebola and Marburg

NIH-sponsored trial of second COVID-19 booster shots begins enrolling adult participants

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

A ferritin nanoparticle candidate vaccine for COVID

How malaria drugs could play a part in treating chemotherapy-resistant head and neck cancers

New trial examines the effectiveness of a two-pronged immunotherapy for glioblastomas

Hydrocortisone does not prevent bronchopulmonary dysplasia in preterm infants

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

Trial reveals effectiveness of axi-cel as first-line treatment for high-risk lymphoma

Trial shows safety and immunogenicity of immunotherapy with chemoradiation in cervical cancer patients

HRR mutational status associated with survival outcomes in recurrent platinum-sensitive ovarian cancer

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

University of Kentucky begins world’s first clinical trial for LATE

New trial finds signs of preventive cardiovascular effects for cocoa flavanols

New Phase 1 clinical trial of mRNA HIV vaccine enrolls first participant

NIH launches Phase 1 clinical trial evaluating three experimental mRNA HIV vaccines

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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