Genomics

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Complete map of human DNA recombination unlocks secrets of genetic diversity

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction.

23 Jan 2025

Breakthrough study links genetic mutations to epigenetic changes in aging

Researchers at University of California San Diego School of Medicine have published results that shed new light on an old question: what causes aging at the molecular level? Their findings, published in Nature Aging, describe a never-before-seen link between the two most accepted explanations: random genetic mutations and predictable epigenetic modifications.

21 Jan 2025

NIH provides $14 million to support human genome research diversification

Washington University School of Medicine in St. Louis has received two large grants renewing funding for the Human Pangenome Reference Sequencing Project.

21 Jan 2025

Researchers uncover how PICH protein protects DNA during cell division

Researchers at The University of Hong Kong (HKU) have made an exciting discovery about how human cells protect DNA during cell division, offering new insights into combating diseases such as cancer.

21 Jan 2025

Study identifies genetic variations linked to allergic sensitization

Humans are continuously exposed to various environmental allergens (antigens), such as pollen, food, and dust mites.

21 Jan 2025

Research shows epigenetic aging in the blood as potential breast cancer marker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled "DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility."

21 Jan 2025

Symbiosis and horizontal gene transfer shape leaf beetle evolution

With more than 50,000 described species, the leaf beetle family is distributed worldwide and represents about a quarter of the species diversity of all herbivores.

20 Jan 2025

Ancient viral DNA plays crucial role in early embryo development

Over half of our genomes consists of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life.

20 Jan 2025

New approach combines two methods to study disordered proteins

Researchers of Mainz University and EMBL Hamburg present a new approach to determine the form of disordered proteins by using two different methods simultaneously in a single sample.

20 Jan 2025

COMET model enhances disease prediction with deep learning

Researchers developed COMET, a deep learning framework that leverages electronic health records and omics data to improve predictive modeling and uncover biological insights.

19 Jan 2025

Breakthrough reveals how DNA and RNA epigenetics work together to control genes

Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally.

17 Jan 2025

Over 500 European patients diagnosed through groundbreaking genetic research

More than 500 European patients with unknown conditions have received a diagnosis through new genetic research.

17 Jan 2025

Bidirectional movement drives DNA loop formation

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only. The discovery, which is published in Cell, is key to understanding how these motors shape our genome and regulate our genes.

17 Jan 2025

New genetic risk factors for depression identified across global populations

New genetic risk factors for depression have been identified across all major global populations for the first time, allowing scientists to predict risk of depression regardless of ethnicity.

15 Jan 2025

Study links epigenetic mechanism to placental blood vessel development

If the development of blood vessels in the placenta is impaired, fetal growth retardation may result. Scientists from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University discovered that the correct development of functioning blood vessels in the mouse placenta is controlled epigenetically: One of the enzymes that modify gene activity using methyl groups is responsible.

15 Jan 2025