Genomics

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Genomic sequencing to provide precision medicine for aromatase deficiency

An international team of scientists from Switzerland Spain, has studied the genetic basis of aromatase deficiency, a rare metabolic disorder that prevents the production of estrogens in humans, according to new research in JCEM.

30 Jun 2020

GHGA to address need for access to genomic and phenomic data

In Germany, there is currently a lack of infrastructure to deal with high-volume biological and biomedical data, such as data found in medical records.

30 Jun 2020

Antibiotic resistance genes tend to persist in E. coli through 'genetic capitalism'

We have known for some time that over-use of antibiotics is causing a frightening increase in antibiotic resistance in bacteria, through the rapid spread of antibiotic resistance genes.

29 Jun 2020

Researchers identify a novel mutation through whole-exome sequencing

Long QT syndrome (LQTS), caused by an ion channel-related gene mutation, is a malignant heart disease with a clinical course of a high incidence of ventricular fibrillation and sudden cardiac death in the young.

27 Jun 2020

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of poorly understood malignant skin cancers collectively known as Paget's disease.

26 Jun 2020

PrecisionLife scientists identify 68 genes linked to severe COVID-19 risk

PrecisionLife’s unique AI platform has found 68 genes associated with risk of developing severe COVID-19 after analysis of the genomes of 929 patients from the UK Biobank who had a severe response to SARS-CoV-2.

26 Jun 2020

Single-cell sequencing method reveals possible evolutionary trajectories of cancer cells

The ability to sequence the genome of a tumor has revolutionized cancer treatment over the last 15 years by identifying drivers of cancer at the molecular level.

25 Jun 2020

Certain genes that predispose to cancer also affect the immune system, study shows

The study shows that the involvement of certain genes that predispose to cancer also affects the immune system, which could facilitate tumor growth.

25 Jun 2020

Whole genome sequencing can improve diagnosis and treatment of patients with rare diseases

A research programme pioneering the use of whole genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease.

24 Jun 2020

Researchers develop eDNA method to prevent emergence of pathogens

As the SARS-CoV-2 puts a new focus on zoonotic pathogens, a Washington State University researcher has developed a method to use environmental DNA (eDNA) to detect disease in the vast international trade of aquatic animals.

24 Jun 2020

New technique helps measure dNTP concentrations with greater sensitivity

A highly sensitive and easy-to-use technique applicable for tissue samples can be useful, for example, to researchers specialised in mitochondrial diseases and cancer.

24 Jun 2020

Researchers develop less invasive genetic tools to understand cellular activity

Graduate student Ubadah Sabbagh placed a cold glass slide on the microscope. It was getting late and the lab was quiet.

24 Jun 2020

Long-term endurance training alters the activity of genes involved in metabolic health

Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health.

23 Jun 2020

Researchers identify genes that determine the optimal time of flowering

How do plants know when it is time to flower? Researchers at Martin Luther University Halle-Wittenberg (MLU) have studied this question and identified two genes that are key to this process.

23 Jun 2020

Patient genetics associated with wound microbiome composition and healing

In a first-of-its-kind study, researchers have determined that genetics may play a role in how wounds heal.

22 Jun 2020

Differences in accumulation of genetic mutations could help predict lifespan, fertility

Differences in the rate that genetic mutations accumulate in healthy young adults could help predict the remaining lifespan in both sexes and the remaining years of fertility in women, according to the University of Utah Health scientists.

19 Jun 2020

Viruses can steal genetic signals from hosts to expand their own genomes

Like a scene out of "Invasion of the Body Snatchers," a virus infects a host and converts it into a factory for making more copies of itself.

19 Jun 2020

Using stem cells to study the developmental effects of Neandertal DNA

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

18 Jun 2020

Coastal Genomics automates DNA purification process using 3D printing – accelerating cancer research, prenatal screening and numerous other fields by partnering with Sculpteo

Coastal Genomics, experts in life sciences automation, selected Sculpteo, a leader in online 3D printing and digital manufacturing, to develop unique components for an automated DNA purification process.

18 Jun 2020

Scientists use CRISPR tool to make rapid, precise cuts in genomic material

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

18 Jun 2020

Genomics

Genomic sequencing to provide precision medicine for aromatase deficiency

GHGA to address need for access to genomic and phenomic data

Antibiotic resistance genes tend to persist in E. coli through 'genetic capitalism'

Researchers identify a novel mutation through whole-exome sequencing

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

PrecisionLife scientists identify 68 genes linked to severe COVID-19 risk

Single-cell sequencing method reveals possible evolutionary trajectories of cancer cells

Certain genes that predispose to cancer also affect the immune system, study shows

Whole genome sequencing can improve diagnosis and treatment of patients with rare diseases

Researchers develop eDNA method to prevent emergence of pathogens

New technique helps measure dNTP concentrations with greater sensitivity

Researchers develop less invasive genetic tools to understand cellular activity

Long-term endurance training alters the activity of genes involved in metabolic health

Researchers identify genes that determine the optimal time of flowering

Patient genetics associated with wound microbiome composition and healing

Differences in accumulation of genetic mutations could help predict lifespan, fertility

Viruses can steal genetic signals from hosts to expand their own genomes

Using stem cells to study the developmental effects of Neandertal DNA

Coastal Genomics automates DNA purification process using 3D printing – accelerating cancer research, prenatal screening and numerous other fields by partnering with Sculpteo

Scientists use CRISPR tool to make rapid, precise cuts in genomic material

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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