Genomics

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Scientists identify over 5,000 genetic variants that enable certain cancers to thrive

Researchers performed saturation genome editing of the BAP1, whose dysfunction is related to cancer and impaired neurodevelopment.

10 Jul 2024

New platform developed to probe the function of genes involved in metabolism

A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism -; the sum of all life-sustaining chemical reactions.

9 Jul 2024

Machine learning identifies cancer-driving mutations at CTCF binding sites

Researchers developed a machine learning tool, CTCF-INSITE, to identify mutational hotspots at persistent CTCF binding sites across various cancers, highlighting their role in genomic structure disruption and cancer progression.

7 Jul 2024

Phages use selfish DNA to outmaneuver competitors

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

5 Jul 2024

Scientists map all the possible outcomes of changes to key tumor-suppressing gene

Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer.

5 Jul 2024

DNA repair mutations act as a switch for bowel cancer

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

5 Jul 2024

Study offers new insights into the evolution of foldable proteins

A new study led by Rice University's Peter Wolynes offers new insights into the evolution of foldable proteins. The research was published in the Proceedings of the National Academy of Sciences.

3 Jul 2024

AI uncovers potential cancer drivers hidden in 'junk' regions of DNA

Using artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called 'junk' regions of DNA, opening up possibilities for a new approach to diagnosis and treatment.

2 Jul 2024

TRPC5 gene identified as a diagnostic marker of obesity and postpartum depression

Researchers at Baylor College of Medicine, the University of Cambridge and collaborating institutions have discovered that alterations in the human gene TRPC5 cause obesity and postpartum depression.

2 Jul 2024

Key transcription factor enhances anthocyanin production in wounded grapevines

A recent study sheds light on the biochemical response of grapevines to wounding stress. It reveals that the transcription factor VvWRKY5 is a key regulator that enhances anthocyanin production, which serves as a protective mechanism for the plant.

2 Jul 2024

Recombinhunt: An important tool to combat future pandemics

Combating future pandemics through data analysis of recombinant virus genomes. A study published in the prestigious journal Nature Communication presents the promising results of RecombinHunt, a new data-driven method developed by the Department of Electronics, Information and Bioengineering of the Politecnico di Milano and the University of Milan, which can identify, with high accuracy and computational efficiency, recombinant SARS-CoV-2 genomes with one or two breakpoints.

2 Jul 2024

From Africa to Eurasia: Genetic insights into human migration and cold adaptation

"Who are we and where do we come from?" This quintessential question has intrigued humanity for millennia.

2 Jul 2024

Modulating gene expression using small molecules

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

2 Jul 2024

Whole genome sequencing can improve clinical care of childhood cancer

Whole genome sequencing has improved clinical care of some children with cancer in England by informing individual patient care.

2 Jul 2024

Cellular Origins acquires Actia Platform IP to enhance automated cell therapy manufacturing

Cellular Origins, a TTP Company, focused on enabling scalable, cost-effective, and efficient manufacture of cell and gene therapies (CGTs), today announced the acquisition of the ACTIA (Autologous Cell Therapy Industrial Automation) Platform IP, developed by Geoff Hodge whilst CEO of SOTIO Biotech US. The ACTIA Platform complements Cellular Origins’ existing approach and will accelerate and expand R&D efforts to further develop the Company’s robotic solution for automated cell therapy manufacturing, Constellation™.

From Cellular Origins 2 Jul 2024

Study finds genetic links between childhood weight gain and early puberty

Genes can indirectly influence the age at which girls have their first period by accelerating weight gain in childhood, a known risk factor for early puberty, a Cambridge-led study has found.

1 Jul 2024

Researchers shine light on the nuanced functions and intricate regulatory methods of RNA editing

Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods of RNA editing, a critical mechanism underlying brain development and disease.

28 Jun 2024

Northwestern researchers propose scalable framework for synthetic biology education

The field of synthetic biology, the science of manipulating biology, has a lot of "cooks in the kitchen," which has both helped it flourish and made it unusually difficult to create a cohesive, consistent curriculum for students at every level of study.

28 Jun 2024

ERC Advanced Grant aids study on ubiquitin in DNA repair and genome stability

Professor Helle Ulrich, Executive Director of the Institute of Molecular Biology (IMB) and professor at Johannes Gutenberg University Mainz (JGU), has been awarded an Advanced Grant from the European Research Council (ERC).

28 Jun 2024