Genomics

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CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Designing hybrid antibodies with enhanced mobility and signaling capacity

Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances.

25 Jun 2024

Association of HLA-G*0104N allele with increased risk of recurrent pregnancy loss in Kashmiri population

HLA-G gene harbors certain polymorphic variations that can potentially impact its biological activity, and therefore, may confer a risk for recurrent pregnancy loss (RPL).

25 Jun 2024

Genetic variation in people of African ancestry linked to increased risk of diabetes complications

A genetic variation common in people of African ancestry is associated with an increased risk of complications from diabetes, including diabetic retinopathy, according to a report published June 25 in the journal Nature Medicine.

25 Jun 2024

Novel genetic predisposition to being overweight or obese identified

Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.

25 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024

KU researchers uncover role of Src gene in nervous system development

Many people are familiar with oncogenes -; genes long known to be involved in cancers in humans, such as the gene "Src."

24 Jun 2024

Antisense RNA acts as a cellular 'booster' for gene expression, study finds

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

24 Jun 2024

Dietary sucrose modulates lithium's regulatory activity in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, "Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster."

24 Jun 2024

How random gene activity shapes lifespan in C. elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

21 Jun 2024

Decoding broccoli’s genome: Advances in glucosinolate biosynthesis and health benefits

A detailed genomic study of broccoli has revealed the genetic foundations for the production of glucosinolates (GSLs), compounds celebrated for their health benefits, including anti-carcinogenic properties.

21 Jun 2024

Study links lifetime cannabis use with substance use, mood disorders, celiac, and infectious diseases

Researchers identify genetic loci associated with lifetime and frequency of cannabis use.

21 Jun 2024

Role of SMIM1 gene in obesity uncovered

Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.

20 Jun 2024

Stilla Technologies expands U.S. presence through strategic distribution relationship with Avantor and introduces advanced content offerings

Stilla, a pioneer in the field of genomics and digital PCR, is excited to announce its expansion in the United States via a strategic distribution relationship with Avantor, a global leader in life sciences and advanced technology solutions.

From Stilla Technologies 20 Jun 2024

Is coffee good or bad? Genetic study investigates health correlations

Coffee drinking is a heritable habit, and one that carries a certain amount of genetic baggage.

18 Jun 2024

Personalized medicine approaches for sepsis based on immune response profiling

Sepsis patients could be treated based on their immune system's response to infection, not their symptoms.

18 Jun 2024

Study reveals diverse risk factors for healthy aging in Latin America

A pioneering study published today in the journal Nature Aging has unveiled significant heterogeneity in the risk factors affecting healthy aging in Latin America and emphasized the limitations of current models of brain health, which are primarily based on data from high-income countries.

17 Jun 2024

CSHL researchers reveal MED12 as key player in basal-like pancreatic cancer

Things aren't always as they seem. Take pancreatic cancer, for example. In up to one in 10 cases, researchers have documented a peculiar characteristic.

17 Jun 2024