Genomics

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New study delves deeper into individual genomic differences than ever before

Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or "spelling mistakes" in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions and rearrangements of large segments of DNA.

17 Apr 2019

Researchers annotate key neuronal proteins in lamprey genome

The lamprey, an eel-like primitive vertebrate, is a popular organism for neurobiology studies because it has a relatively simple nervous system.

16 Apr 2019

CRISPR-scanning could lead to more effective treatments for cancer

11,000 people are predicted to die from acute myeloid leukemia in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors.

16 Apr 2019

Spatial orgnization of the genome can be altered using small molecules

Researchers have discovered that the spatial organization of the genome can be altered using small molecule compounds which are considered as promising anti-cancer drugs.

16 Apr 2019

Researchers complete large analysis of new gene fusion responsible for development of cancers

A consortium of researchers led by Georgetown Lombardi Comprehensive Cancer Center investigators have completed the largest analysis of a new gene fusion they believe is responsible for development of a wide spectrum of cancer types.

16 Apr 2019

Spotlight on ECCMID 2019: Detecting Disease & Managing Infections

This article covers some of the highlights of ECCMID 2019, with insights into some of the companies and products being featured at the event.

From ESCMID 15 Apr 2019

New genetic treatment removes antibiotic resistance from bacteria

Jane and Aatos Erkko foundation has awarded University of Jyväskylä'sAcademy Research Fellow Matti Jalasvuori's research group 255 000 euro grant for investigating the conjugative transfer of anti-antibiotic resistance genetic elements.

12 Apr 2019

Large-scale screen of mouse mutants reveals 38 new genes involved in hearing loss

A large-scale screen of mouse mutants has revealed multiple new genes involved in hearing loss, according to a study publishing April 11 in the open-access journal PLOS Biology by Karen Steel of King’s College London and the Wellcome Sanger Institute, and colleagues.

12 Apr 2019

DNA fragments from ancient hominins reveal new branches of the Denisovan lineage

It's widely accepted that anatomically modern humans interbred with their close relatives, the Neanderthals and Denisovans, as they dispersed out of Africa.

12 Apr 2019

Researchers identify rare SRC-1 gene variants related to human obesity

Maintaining a healthy body weight is no simple matter. A better understanding of how the body regulates appetite could help tip the scale toward the healthy side.

12 Apr 2019

Modern humans interbred with multiple Denisovan populations, suggests study

The findings are based on a new study led by Murray Cox from Massey University in New Zealand and made possible by sampling efforts led by Herawati Sudoyo from the Eijkman Institute for Molecular Biology in Jakarta, Indonesia.

12 Apr 2019

Study describes vulnerability shared by large subset of cancer cell lines

Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth.

12 Apr 2019

Rare gut condition is more predictable from individual's genetic makeup, study finds

Hirschsprung disease - a rare condition where the failure of gut nerves to develop before birth leads to impaired bowel contractions that prevent infants from passing stool - is more predictable from an individual's genetic makeup than previously envisioned.

11 Apr 2019

Bacteria share genes with one another, even across tissue boundaries

Bacteria in the human body are sharing genes with one another at a higher rate than is typically seen in nature, and some of those genes appear to be traveling - independent of their microbial hosts - from one part of the body to another, researchers report in the journal Scientific Reports.

11 Apr 2019