Genomics

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Will gene-editing of human embryos ever be justifiable?

World-leading medical ethicist Professor Arthur Caplan has published a series of recommendations with the aim of addressing worldwide concerns over gene editing of human embryos.

30 Apr 2019

First GWAS for Type 2 diabetes in youth reveals seven genetic variants associated with the disease

Pediatric diabetes and genetic researchers with the First Genome-Wide Association Study (GWAS) for Type 2 diabetes in youth said they discovered seven genetic variants associated with the disease in young people.

30 Apr 2019

New approach could simplify identification of transport proteins in mycobacteria

A team headed by Dr. Claudia Jessen-Trefzer of the University of Freiburg's Institute for Pharmaceuticals Sciences has for the first time identified a transport protein in mycobacteria which is responsible for the uptake of the nutrient L-arabinofuranose.

30 Apr 2019

Cannabis, Alcohol and the Epigenome

With the legalization of cannabis in many US states, we explore the epigenetic effects of cannabis, cannabis-derived products, and alcohol.

29 Apr 2019

Researchers use genomics to solve a 20-year case study

After 20 years, a patient's family received an answer to a decades-long genetic mystery. Their daughter had two rare disorders, Angelman syndrome and P450scc deficiency, which was detected after researchers found out she had uniparental disomy, two copies of chromosome 15 from one parent and none from another.

28 Apr 2019

CircRNAs bind to dsRNA-activated protein kinase which is linked to innate immunity

Covalently closed circular RNAs are produced by precursor mRNA back-splicing the exons of thousands of genes in eukaryotes.

26 Apr 2019

Genetic mutations in brain development lead to discovery of rare genetic diseases

Mutations in a gene involved in brain development have led to the discovery of two new neurodevelopmental diseases by an international team led by researchers at McGill University and CHU Sainte-Justine Research Center.

26 Apr 2019

New genetic test identifies many disease-causing gene variations in high-risk populations

Researchers at Nemours Children's Health System have developed a new low-cost genetic test that accurately identified more than 200 known disease-causing gene variations in two high-risk populations, the Old Order Amish and Old Order Mennonites of Lancaster County, Pennsylvania.

25 Apr 2019

Stem cells in hair follicles have potential to regenerate myelin sheath that coats neurons

A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, reports Thomas Hornyak of the VA Maryland Health Care System and the University of Maryland School of Medicine and colleagues, in a new study published 24th April in PLOS Genetics.

25 Apr 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

New review highlights how lifestyle affects our genes

In the past decade, knowledge of how lifestyle affects our genes, a research field called epigenetics, has grown exponentially.

24 Apr 2019

DNA rearrangement may predict poor outcomes in multiple myeloma

A certain type of DNA marker predicts poor outcomes in multiple myeloma, researchers at Winship Cancer Institute, Emory University have found.

24 Apr 2019

Yposkesi chairman to speak on ‘Manufacturing and the CDMO Perspective’ at Cell and Gene Meeting

Yposkesi, a leading CDMO for gene therapy viral vector manufacturing, today announces that its chairman Frederic Revah Ph.D. will participate as a panelist on the topic of ‘Manufacturing and the CDMO Perspective’.

23 Apr 2019

Novel ECCITE-seq technique expands multimodal single cell analysis

A new technique called ECCITE-seq, developed by scientists at the New York Genome Center's Technology Innovation Lab, allows researchers to perform high-throughput measurements of multiple modalities of information from single cells.

From 10x Genomics, Inc. 23 Apr 2019

Scientists identify 104 high-risk genes for schizophrenia

Using a unique computational "framework" they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute has identified 104 high-risk genes for schizophrenia.

23 Apr 2019

Potential of liquid biopsy in cancer biomarker detection and prenatal testing

The promise and challenges of liquid biopsy, an emerging, noninvasive method for targeted disease diagnosis and detection of cancer biomarkers to enable improved and personalized therapy, is the focus of a new special issue of Genetic Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

22 Apr 2019

Research uncovers critical RNA processing aberrations in ALS and FTD

Research by a Barrow Neurological Center scientist on mechanisms of dysfunctional RNA processing in ALS and frontal temporal dementia was published in the April issue of Acta Neuropathologica.

21 Apr 2019

Key research takeaways from ECCMID 2019

This article aims to provide a brief overview of the key themes of the 29th ECCMID conference and update readers on current research projects.

From ESCMID 19 Apr 2019

New scoring system based on genetic markers predicts obesity risk at birth

Researchers have come up with a scoring system based on genetic markers that predicts an individual's inborn risk for obesity.

19 Apr 2019

Scientists deploy CRISPR gene-editing tool to engineer multiple edits

Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments of DNA extracted from a human cell, according to a new study published today in The CRISPR Journal.

19 Apr 2019