Genomics

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New collection of transgenic flies could accelerate biomedical discovery

For more than 100 years, the humble fruit fly has been used to understand fundamental biological processes and has been a crucial tool for rapid preclinical gene discovery for myriads of human diseases.

6 Apr 2018

Largest genomic analysis supports additional classification of tumors

University of North Carolina Lineberger Comprehensive Cancer Center researchers are reporting the concluding findings from a major analysis of nearly 10,000 different tumor samples that focused on identifying similarities between cancers based on changes in their genes, and the way their genes are expressed.

6 Apr 2018

Johns Hopkins scientist calls for more integration of epigenetics and genetics research

In a review article published April 5 in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics.

6 Apr 2018

Scientists identify key genetic events responsible for initiating childhood leukemia

The key genetic events responsible for initiating the early stages of a type of childhood leukemia have been identified by scientists at The Institute of Cancer Research, London. Insights into the ‘founder’ genetic mutation for this type of leukemia, present in all the cancer cells, could be used in the development of new targeted drugs.

6 Apr 2018

Waking up “sleeping” stem cells in the brain could improve its ability to repair injury

Researchers have identified a new type of stem cell that could boost the brain’s ability to repair damage caused by brain injury or disease.

6 Apr 2018

Scientists create organoids that could help guide bladder cancer treatment

Researchers have created patient-specific bladder cancer organoids that imitate many of the features of real tumors and may therefore be used to study how cancer evolves.

6 Apr 2018

Study provides systematic view of gene enhancer activity in diverse tumors

At the heart of any cancer diagnosis or treatment are cells. If one thinks of the cell components controlling gene activation as a Russian nesting-doll of gene regulatory layers, within those increasingly smaller tiers are short pieces of non-coding DNA called enhancers.

5 Apr 2018

New method simplifies genetic modification of T-cells in mice

A new method enables genes in living T-cells in mice to be modified quickly and efficiently. It makes use of plasmids, a tried-and-tested method of genetic engineering.

5 Apr 2018

Research links DNA variants to increased risk of IBS in women

New research coordinated by Karolinska Institutet in Sweden links certain DNA variants to increased risk of irritable bowel syndrome in women. The findings, published in the scientific journal Gastroenterology, might help explain why IBS is more common in women than in men.

5 Apr 2018

Researchers suggest a theory for the evolution of HIV from SIV

A new study has shed light on how HIV may have evolved from the simian immunodeficiency virus (SIV) that originated in non-human primates.

5 Apr 2018

DNA-mimicking synthetic molecule could lead to new HIV treatment

Researchers have developed a synthetic compound that mimics the surface of DNA and is able to inhibit several DNA-processing enzymes.

4 Apr 2018

Human genome is like a time machine, says researcher

The human genome is a bit like a time machine, says Ben Voight, an associate professor in Systems Pharmacology and Translational Therapeutics and of Genetics in Penn's Perelman School of Medicine.

3 Apr 2018

Scientists develop futuristic gene therapy for liver cancer

Genetically engineered human T cells that are effective at fighting liver cancer in mice may one day help patients fight liver cancer, say researchers.

3 Apr 2018

Computational biologists develop algorithm to align datasets with single-cell resolution

A team of computational biologists has developed an algorithm that can 'align' multiple sequencing datasets with single-cell resolution.

3 Apr 2018

Researchers identify 200 mutations in non-coding DNA that play role in cancer

Most of the human genome - 98 percent - is made up of DNA but doesn't actually encode genes, the recipes cells use to build proteins.

2 Apr 2018

The Human Microbiome – A New Potential Fingerprint in Forensic Evidence?

Professor Jack Gilbert gives an overview of the Burglary Microbiome Project, which he discussed at Pittcon 2018.

From Pittcon 29 Mar 2018

Study provides insights into how male germ cells avoid genome instability

A group of researchers at Osaka University reported the function of GTSF1 in male germ cells. The study, which can be read in EMBO Reports, shows that GTSF1 is an essential factor for secondary piRNA biogenesis by regulating piRNA-mediated cleavage of target RNA.

28 Mar 2018

New gene therapy may help the brain to heal following stroke and other injuries

Researchers have discovered a genetic trigger that may improve the brain’s ability to heal in conditions such as stroke, concussion and spinal cord injury.

28 Mar 2018

EPFL researchers uncover how the circadian clock regulates 3D chromatin structure

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24-hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA-protein complex of the cell. The work is published in Genes & Development.

28 Mar 2018