Genomics

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CRISPR shows potential to reduce diseases spread by mosquitoes

Research at the University of California, Riverside, have shown that it is possible for transgenic mosquitos to stably express the Cas9 enzyme in their germline. Cas9 addition will allow the utilization of the CRISPR gene editing tool to carry out efficient and highly targeted changes to the DNA of the mosquitoes.

16 Nov 2017

Scientists find key that allows neural differentiation of microRNA-deficient pluripotent stem cells

The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to all those different cell fates.

15 Nov 2017

Researchers visualize mechanism of CRISPR-Cas9 genetic-engineering technique

Researchers at Kanazawa University and the University of Tokyo report in Nature Communications the visualization of the dynamics of ‘molecular scissors’ — the main mechanism of the CRISPR-Cas9 genetic-engineering technique.

15 Nov 2017

UCR researchers develop transgenic mosquitoes to help reduce spread of infectious diseases

Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to the mosquitoes' DNA.

14 Nov 2017

Study points at lysosomal storage disorder genes as potential key contributors to Parkinson's

An international study has shed new light on the genetic factors associated with Parkinson's disease, pointing at a group of lysosomal storage disorder genes as potential major contributors to the onset and progression of this common neurodegenerative disorder. The study appears in the journal Brain.

14 Nov 2017

Dresden researchers develop molecular smoke alert for key human cancer gene

If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the TP53 gene, the most important human cancer gene. The alert goes on if the TP53 gene is mutated in cells.

14 Nov 2017

Scientists devise new way to control single neurons using optogenetics

Researchers at MIT and Paris Descartes University have developed a new optogenetic technique that sculpts light to target individual cells bearing engineered light-sensitive molecules, so that individual neurons can be precisely stimulated.

13 Nov 2017

Gene technology can be potential game-changer for agriculture

Consumers will soon be eating gene-edited foods that have added nutrients, potatoes that do not turn brown, and mushrooms with a longer shelf life, scientists at The University of Queensland predict.

10 Nov 2017

Repositive introduces first Global PDX Directory at AACR conference

The first Global PDX Directory for proprietary and open source PDX models is being introduced by Cambridge (UK) based benefit corporation, Repositive, at the American Association for Cancer Research’sInternational Conference, on Molecular Targets and Cancer Therapeutics, hosted in conjunction with the European Organisation for Research and Treatment of Cancer and the National Cancer Institute, in Philadelphia, USA, 26-30 October 2017.

1 Nov 2017

Powerful toolkit uncovers rare tumor suppressor genes

A new statistical model has enabled researchers to pinpoint 27 novel genes thought to prevent cancer from forming, in an analysis of over 2000 tumors across 12 human cancer types. The findings could help create new cancer treatments that target these genes, and open up other avenues of cancer research.

31 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

New enzyme may one day enable genome surgery that erases harmful mutations

DNA editing just got a sharp, new pencil. Researchers have built an enzyme that can perform a previously impossible DNA swap, directly changing the DNA base pair from an A•T to a G•C.

26 Oct 2017

IBN researchers create DNA technology with two new genetic alphabets

Just like how alphabets are strung together to form words, our DNA is also strung together by alphabets to encode proteins. Our DNA contains only 4 natural genetic alphabets - A, C, G and T, which hold the blueprint for the production of proteins that make our bodies work.

26 Oct 2017

Timing of DNA damage within checkpoints matters to a cell's fate, study reports

DNA damage occurs routinely within your cells due to sun exposure, smoking and sometimes during the normal process of making new DNA.

26 Oct 2017

New analysis method allows to efficiently search for gene transfers onto Y chromosome

Y chromosomes, which are only inherited paternally, evolved from "normal" chromosomes known as autosomes. As males only possess one Y chromosome, there is no counterpart for recombination, the direct exchange of genetic material.

25 Oct 2017

Researchers discover mechanism that corrects protein misfolding in plants

Various human nervous system diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer's, Huntington's, and Parkinson's diseases, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death.

25 Oct 2017

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease.

24 Oct 2017

New genetic variants contribute to the risk of breast cancer in women, study reveals

A new study reveals seventy-two novel genetic variants that are responsible for breast cancer risk. Published in the journals Nature and Nature Genetics, of these 72 variants, 65 are common variants that predispose patients to breast cancer and a further seven variants predispose particularly to estrogen -receptor negative breast cancer - the subcategory of cases that do not respond to hormonal treatments.

24 Oct 2017

Mysterious DNA modification appears more in the brain under stress

With advances in genomics, scientists are discovering additional components of the DNA alphabet in animals. Do these unusual chemical modifications of DNA have a special meaning, or are they just signs that cellular machines are making mistakes?

24 Oct 2017

Research provides insight into how two stands of double helix separate during replication

Life would be impossible if the DNA in dividing cells were replicated with anything less than near-perfect precision. Every time a nucleated cell commits to becoming two cells, every "letter" of its genome must be replicated once and only once.

24 Oct 2017

Genomics

CRISPR shows potential to reduce diseases spread by mosquitoes

Scientists find key that allows neural differentiation of microRNA-deficient pluripotent stem cells

Researchers visualize mechanism of CRISPR-Cas9 genetic-engineering technique

UCR researchers develop transgenic mosquitoes to help reduce spread of infectious diseases

Study points at lysosomal storage disorder genes as potential key contributors to Parkinson's

Dresden researchers develop molecular smoke alert for key human cancer gene

Scientists devise new way to control single neurons using optogenetics

Gene technology can be potential game-changer for agriculture

Repositive introduces first Global PDX Directory at AACR conference

Powerful toolkit uncovers rare tumor suppressor genes

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

New enzyme may one day enable genome surgery that erases harmful mutations

IBN researchers create DNA technology with two new genetic alphabets

Timing of DNA damage within checkpoints matters to a cell's fate, study reports

New analysis method allows to efficiently search for gene transfers onto Y chromosome

Researchers discover mechanism that corrects protein misfolding in plants

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

New genetic variants contribute to the risk of breast cancer in women, study reveals

Mysterious DNA modification appears more in the brain under stress

Research provides insight into how two stands of double helix separate during replication

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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