Genomics

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People with genetic susceptibility to Alzheimer's may have greater cognitive deficits with sleep-disordered breathing

People who carry a genetic susceptibility to Alzheimer's disease appear to be at greater risk of diminished cognition from sleep-disordered breathing than those without the susceptibility, according to new research published online, ahead of print in the Annals of the American Thoracic Society.

21 Jul 2017

Study provides deeper understanding into genetic basis of neuropsychiatric disorders

A study by scientists at the Children's Medical Center Research Institute at UT Southwestern is providing insight into the genetic basis of neuropsychiatric disorders.

21 Jul 2017

Genetic variation linked to greater tuberculosis susceptibility

Researchers have shown that a single nucleotide change in a gene that affects production of hepcidin--a peptide involved in inflammation, immunity, and control of iron levels--is associated with greater susceptibility to extrapulmonary tuberculosis.

21 Jul 2017

Wayne State researchers receive $1.9 million NIH grant to better understand rare genetic disorders

A team of Wayne State University researchers recently received a $1.9 million grant from the National Eye Institute of the National Institutes of Health to better understand leukodystrophies (LD) and genetic Leukoencephalopathies (gLE), rare genetic disorders affecting the white matter -- myelin -- in the central nervous system.

21 Jul 2017

New genomic research partnership promises to redefine and transform cancer treatment

Personalized cancer therapies are on the horizon thanks to a new genomic cancer research partnership between the Gene Editing Institute of Christiana Care Health System's Helen F. Graham Cancer Center & Research Institute and the biotechnology company NovellusDx.

21 Jul 2017

Epigenetic dysregulation with age in normal breast tissue may contribute to cancer risk

Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history.

20 Jul 2017

Study identifies new mutations linked to hereditary neuroendocrine tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component. Half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle, a metabolic route involved in cellular respiration.

20 Jul 2017

Methicillin use not to blame for MRSA, say researchers

The introduction of methicillin into clinical practice is not what caused the emergence of methicillin resistant Staphylococcus aureus (MRSA), report researchers. According to a collaborative study by the University of St Andrews, University of Dundee and the Wellcome Trust Sanger Institute, MRSA existed long before clinicians started using the antibiotic.

20 Jul 2017

Lunatic fringe gene plays role in regulating fate of neural stem cells

The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated.

19 Jul 2017

UD researchers receive $1 million Keck Foundation grant to dive deep into lives of microbes

Even in sediment cores extracted more than a mile beneath the ocean floor, you'll find them. Tiny organisms only a cell in size chug along ever so slowly.

19 Jul 2017

Bone strength may be inherited, study shows

A new study indicates that bone strength may be inherited and that its genetic determinants are to some extent shared with bone mineral density.

19 Jul 2017

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also have up to a 39 percent chance to develop ovarian cancer.

19 Jul 2017

Study seeks to understand genetic synergy in cleft palate

Like all of the individual elements of fetal development, palate growth is a marvel of nature. In part of this process, ledges of tissue on the sides of the face grow downwards on each side of the tongue, then upward, fusing at the midline at the top of the mouth.

19 Jul 2017

Researchers discover gene mutations that worsen respiratory infections among children

Researchers funded by the Swiss National Science Foundation have discovered mutations that worsen respiratory infections among children. Their study explains the mechanism involved.

18 Jul 2017

Study provides insights into intergenerational inheritance of epigenetic information

We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or our lifestyle take a major role in regulating the DNA by switching genes on and off.

18 Jul 2017

Scientists uncover new genetic markers that predispose individuals to lupus

Scientists from an international consortium have identified a large number of new genetic markers that predispose individuals to lupus.

18 Jul 2017

Study identifies new gene involved in Fanconi anemia

Researchers from the group led by UAB Chair Professor Dr Jordi Surrallés at the Hospital de la Santa Creu i Sant Pau, Barcelona, the Universitat Autònoma de Barcelona and the CIBER of Rare Diseases participated in a study which has led to the identification of a new gene involved in Fanconi anemia, a rare genetic disease.

17 Jul 2017

Genomics

People with genetic susceptibility to Alzheimer's may have greater cognitive deficits with sleep-disordered breathing

Study provides deeper understanding into genetic basis of neuropsychiatric disorders

Genetic variation linked to greater tuberculosis susceptibility

Wayne State researchers receive $1.9 million NIH grant to better understand rare genetic disorders

New genomic research partnership promises to redefine and transform cancer treatment

Epigenetic dysregulation with age in normal breast tissue may contribute to cancer risk

Study identifies new mutations linked to hereditary neuroendocrine tumors

Methicillin use not to blame for MRSA, say researchers

Lunatic fringe gene plays role in regulating fate of neural stem cells

UD researchers receive $1 million Keck Foundation grant to dive deep into lives of microbes

Bone strength may be inherited, study shows

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

Study seeks to understand genetic synergy in cleft palate

Researchers discover gene mutations that worsen respiratory infections among children

Study provides insights into intergenerational inheritance of epigenetic information

Scientists uncover new genetic markers that predispose individuals to lupus

Study identifies new gene involved in Fanconi anemia

Researchers spot two genes that influence person's risk of Alzheimer's disease

Mutations arising after conception may play vital role in autism

Scientists reveal key role of TLK2 gene in placenta development, embryo viability in mice

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

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