Genomics

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UAB researchers reveal key role for RSF1 protein in silencing genes

A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature cells.

31 Aug 2017

Genetics of digestion stayed remarkably the same from fishes to humans, research shows

Scientists have discovered a network of genes and genetic regulatory elements in the lining of the intestines that has stayed remarkably the same from fishes to humans. Many of these genes are linked to human illnesses, such as inflammatory bowel diseases, diabetes and obesity.

30 Aug 2017

Scientists identify novel role for retrotransposons in shaping embryonic chromatin landscape

Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant.

30 Aug 2017

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

26 Aug 2017

Scientists develop new system to identify and characterize regulatory DNA sequences

Scientists from the Children's Medical Center Research Institute at UT Southwestern have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

24 Aug 2017

JAX wins NIGMS funding to decipher role of RNA structure in gene regulation

With new funding from the National Institute of General Medical Sciences totaling $2,059,618 over five years, JAX Assistant Professor Zhengqing Ouyang, Ph.D., will build a research program to reveal the roles of RNA structure in post-transcriptional regulation at the genome scale.

21 Aug 2017

Penn researchers receive two new post-doctoral training grants for genomic science

Researchers from the Perelman School of Medicine at the University of Pennsylvania have received two highly competitive post-doctoral Institutional Training Grants for genomic science from the National Human Genome Research Institute of the National Institutes of Health.

21 Aug 2017

Fruit flies' pheromones reveal sexual attractiveness of females

Life as a fruit fly seems pretty simple: Hatch, grow, eat some fruit, find a mate, produce hundreds of tiny offspring and die -- all in a month or so.

18 Aug 2017

Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations.

17 Aug 2017

Research shows how glutamine plays role in regulating cellular differentiation programs

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to be turned on or off.

17 Aug 2017

GM pigs one step closer to providing organs for human transplant

US scientists are the closest yet to creating genetically modified pigs with organs that can be safely transplanted into humans.

14 Aug 2017

Counteracting premature aging

Aging is the continuing process of such stress exposures, and with advancing age (normal aging), we must carry lots of senescent cells within our bodies. Senescent cells also often provide some ‘bad influences’ to surrounding healthy cells; such as chronic inflammation and tumorigenesis

14 Aug 2017

Researchers develop new technique to locate pathogenic mutations in dark, non-coding genome

When doctors can't find a diagnosis for patient's disease, they turn to genetic detectives. Equipped with genomic sequencing technologies available for less than 10 years, these sleuths now routinely search through a patient's DNA looking for mutations responsible for mysterious diseases.

11 Aug 2017

Vitamin B3 supplementation during pregnancy may prevent birth defects, in-vivo study suggests

Supplementing the diet with vitamin B3 during pregnancy may treat the molecular deficiencies in women that can lead to birth defects, according to a landmark study in Australia. Over the last 12 years, developmental geneticist Sally Dunwoodie (Victor Chang Cardiac Research Institute, Sydney) and team have been studying the genes that influence fetal heart and bone development.

10 Aug 2017

Pitt researcher aims to develop 'smart biomaterials' for reprogramming mammalian cell signaling

Through a process called cell signaling, cells collaborate on necessary functions such as responding to changes in the environment, fighting off threats to the body, or regulating the basic processes that keep the body alive.

4 Aug 2017

Accidental discovery opens up new way to find unknown viruses

A chance discovery has opened up a new method of finding unknown viruses. In research published in the journal Virus Evolution, scientists from Oxford University's Department of Zoology have revealed that Next-Generation Sequencing and its associated online DNA databases could be used in the field of viral discovery.

4 Aug 2017

PerkinElmer introduces affordable clinical genomics services

PerkinElmer, Inc. , a global leader committed to innovating for a healthier world, today announced the launch of PerkinElmer Genetics' clinical genomics services.

3 Aug 2017

Researchers explore genetic differences, hereditary factors involved in hemiplegic cerebral palsy

Hemiplegic cerebral palsy hampers movement in one side of a person's body. In the first genetic study of its kind to exclusively focus on those with hemiplegic cerebral palsy, a group of 26 Canadian researchers has investigated the genetic differences and hereditary factors involved in this neurodevelopmental condition.

3 Aug 2017

In-depth tumor sequencing reveals key molecular drivers of metastatic cancers

Five hundred cancer patients are getting an in-depth look at their genomes as part of a new clinical study that is revealing some of the key molecular drivers of metastatic cancers.

3 Aug 2017

IDT introduces first Cas9 enzyme variant that greatly reduces off-target effects in CRISPR genome editing

Integrated DNA Technologies today announced the launch of the first Cas9 enzyme variant that extensively reduces off-target effects in CRISPR genome editing without compromising on-target activity.

3 Aug 2017

Genomics

UAB researchers reveal key role for RSF1 protein in silencing genes

Genetics of digestion stayed remarkably the same from fishes to humans, research shows

Scientists identify novel role for retrotransposons in shaping embryonic chromatin landscape

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

Scientists develop new system to identify and characterize regulatory DNA sequences

JAX wins NIGMS funding to decipher role of RNA structure in gene regulation

Penn researchers receive two new post-doctoral training grants for genomic science

Fruit flies' pheromones reveal sexual attractiveness of females

Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes

Research shows how glutamine plays role in regulating cellular differentiation programs

GM pigs one step closer to providing organs for human transplant

Counteracting premature aging

Researchers develop new technique to locate pathogenic mutations in dark, non-coding genome

Vitamin B3 supplementation during pregnancy may prevent birth defects, in-vivo study suggests

Pitt researcher aims to develop 'smart biomaterials' for reprogramming mammalian cell signaling

Accidental discovery opens up new way to find unknown viruses

PerkinElmer introduces affordable clinical genomics services

Researchers explore genetic differences, hereditary factors involved in hemiplegic cerebral palsy

In-depth tumor sequencing reveals key molecular drivers of metastatic cancers

IDT introduces first Cas9 enzyme variant that greatly reduces off-target effects in CRISPR genome editing

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