Genomics

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Autism and ADHD linked to neighborhood conditions

Autistic youth who were born in underserved neighborhoods are more likely to have greater attention deficit hyperactivity disorder (ADHD) symptoms than those born in communities with more resources. This is one finding of a new study led by researchers at the UC Davis MIND Institute.

9 Aug 2024

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

Since the genetic code was first deciphered in the 1960s, our genes seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why changes in a gene's code affect health.

9 Aug 2024

New treatment boosts pluripotent stem cell production in mice

Researchers at the Centre for Genomic Regulation (CRG) have discovered a treatment which accelerates the production and quality of pluripotent stem cells in mice.

7 Aug 2024

Social genomics: How friends' genes impact a person's mental health

Mom always said, "Choose your friends wisely." Now a study led by a Rutgers Health professor shows she was onto something: Their traits can rub off on you – especially ones that are in their genes.

7 Aug 2024

AI reveals genetic links in aging, chronic diseases, and lifestyle factors across nine organ systems

Research uncovers how genetic factors influence the biological age of different organ systems, revealing their connections to lifestyle, chronic diseases, and potential therapeutic interventions.

5 Aug 2024

Unraveling the role of neo-sex chromosomes in mitigating sexual conflict

Researchers from Tokyo Metropolitan University have taken a big step in solving the mystery around why animals evolve sex chromosomes.

4 Aug 2024

Unraveling complex genetic and environmental landscape of schizophrenia

Patrick Sullivan, MD, FRANZCP, the Yeargan Distinguished Professor of Psychiatry and Genetics at the UNC School of Medicine, and researchers at the Karolinska Institutet in Stockholm, Sweden, have developed a comprehensive outline of the genetics of schizophrenia.

2 Aug 2024

New study links obesity to bacterium Megamonas

A recent study published in Cell Host & Microbe identifies a potential obesity-linked bacterium, Megamonas, from a large-scale cohort of obese individuals in China.

2 Aug 2024

Using advanced CRISPR to boost efficiency of CAR-T cell therapies

CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for treating acute lymphoblastic leukemia (ALL).

2 Aug 2024

St. Jude develops cost-effective genetic panel for pediatric cancer diagnosis

Scientists at St. Jude Children's Research Hospital have created a panel that is able to provide a diagnosis for >90% of pediatric cancer patients by sequencing 0.15% of the human genome.

1 Aug 2024

New studies reveal common DNA replication mechanisms in humans and yeast

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Sciences.

1 Aug 2024

New nanosensing technique enhances quality control for gene therapy vectors

Over the past few decades, there has been remarkable progress in genetic manipulation technologies, bringing us closer to the point where genes can be modified in vivo.

1 Aug 2024

Vegan diet may slow aging

Vegan diets showed short-term benefits on epigenetic aging compared to omnivorous diets in healthy twins, with reduced epigenetic age metrics observed in the vegan group. However, telomere length and overall mitotic clock values remained unchanged for both diets.

31 Jul 2024

Epigenetic reprogramming and hypothalamic changes in metabolic syndrome

Metabolic syndrome (MetS) is a multifaceted disorder that impacts approximately 20–25% of the global population.

30 Jul 2024

Study finds higher levels of lncRNAs in the testes than previously estimated

Researchers at the University of Toronto have mapped the spatial distribution of around 700 long non-coding RNAs, otherwise known as lncRNAs, in the testes.

30 Jul 2024

Genetic variants associated with Parkinson's more common than estimated

New research has found that genetic variants associated with Parkinson's disease (PD) are more common than researchers previously believed. Investigators in the Parkinson's Foundation-backed PD GENEration study – which reached its goal of 15,000 participants ahead of schedule this spring – found that 13% of participants have a genetic form of PD, which is a significant observation compared to long-standing estimates. Results from the first 3.5 years of the study, which examined a broad North American cohort, were published in the peer-reviewed scientific journal Brain.

30 Jul 2024

Study unveils dual roles of TNF-α receptors in tissue regeneration and cell death

A study published in The EMBO Journal opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work.

29 Jul 2024

Canadian experts urge caution on free genetic testing and data sharing

Free genetic testing, offered partially or fully subsidized by industry, may have trade-offs, and health systems in Canada must carefully weigh potential clinical, ethical, and legal considerations to protect patient data, authors argue in a CMAJ (Canadian Medical Association Journal) commentary https://www.cmaj.ca/lookup/doi/10.1503/cmaj.231588.

29 Jul 2024

Eight-week vegan diet linked to epigenetic age reduction in identical twins

Eating a vegan diet for eight weeks is associated with reductions in biological age estimations based on levels of DNA methylation - a type of chemical modification of DNA (known as an epigenetic modification) that alters gene expression but not DNA itself.

28 Jul 2024

New biomarker helps determine the optimal treatment for colon cancer

Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn't improve the chances of survival for every patient. A study published July 25th, 2024 in Cell Reports Medicine identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy.

27 Jul 2024