Genomics

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From Africa to Eurasia: Genetic insights into human migration and cold adaptation

"Who are we and where do we come from?" This quintessential question has intrigued humanity for millennia.

2 Jul 2024

Modulating gene expression using small molecules

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

2 Jul 2024

Whole genome sequencing can improve clinical care of childhood cancer

Whole genome sequencing has improved clinical care of some children with cancer in England by informing individual patient care.

2 Jul 2024

Cellular Origins acquires Actia Platform IP to enhance automated cell therapy manufacturing

Cellular Origins, a TTP Company, focused on enabling scalable, cost-effective, and efficient manufacture of cell and gene therapies (CGTs), today announced the acquisition of the ACTIA (Autologous Cell Therapy Industrial Automation) Platform IP, developed by Geoff Hodge whilst CEO of SOTIO Biotech US. The ACTIA Platform complements Cellular Origins’ existing approach and will accelerate and expand R&D efforts to further develop the Company’s robotic solution for automated cell therapy manufacturing, Constellation™.

From Cellular Origins 2 Jul 2024

Study finds genetic links between childhood weight gain and early puberty

Genes can indirectly influence the age at which girls have their first period by accelerating weight gain in childhood, a known risk factor for early puberty, a Cambridge-led study has found.

1 Jul 2024

Researchers shine light on the nuanced functions and intricate regulatory methods of RNA editing

Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods of RNA editing, a critical mechanism underlying brain development and disease.

28 Jun 2024

Northwestern researchers propose scalable framework for synthetic biology education

The field of synthetic biology, the science of manipulating biology, has a lot of "cooks in the kitchen," which has both helped it flourish and made it unusually difficult to create a cohesive, consistent curriculum for students at every level of study.

28 Jun 2024

ERC Advanced Grant aids study on ubiquitin in DNA repair and genome stability

Professor Helle Ulrich, Executive Director of the Institute of Molecular Biology (IMB) and professor at Johannes Gutenberg University Mainz (JGU), has been awarded an Advanced Grant from the European Research Council (ERC).

28 Jun 2024

New study links psoriasis severity to skin microbiome dysbiosis

A multi-omics analysis of host-microbe interactions in psoriasis.

28 Jun 2024

CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Designing hybrid antibodies with enhanced mobility and signaling capacity

Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances.

25 Jun 2024

Association of HLA-G*0104N allele with increased risk of recurrent pregnancy loss in Kashmiri population

HLA-G gene harbors certain polymorphic variations that can potentially impact its biological activity, and therefore, may confer a risk for recurrent pregnancy loss (RPL).

25 Jun 2024

Genetic variation in people of African ancestry linked to increased risk of diabetes complications

A genetic variation common in people of African ancestry is associated with an increased risk of complications from diabetes, including diabetic retinopathy, according to a report published June 25 in the journal Nature Medicine.

25 Jun 2024

Novel genetic predisposition to being overweight or obese identified

Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.

25 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024

KU researchers uncover role of Src gene in nervous system development

Many people are familiar with oncogenes - genes long known to be involved in cancers in humans, such as the gene "Src."

24 Jun 2024

Antisense RNA acts as a cellular 'booster' for gene expression, study finds

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

24 Jun 2024

Dietary sucrose modulates lithium's regulatory activity in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, "Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster."

24 Jun 2024