Genomics

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Exploring the immune mechanism induced by BCG vaccine in humanized mouse model

Announcing a new article publication for Zoonoses journal. This study was aimed at screening differentially expressed genes (DEGs) and exploring the potential immune mechanism induced by the Bacillus Calmette-Guerin (BCG) vaccine in a humanized mouse model.

3 Jan 2023

Researchers discover new role of small RNAs in Salmonella infections

Salmonella are food-borne pathogens that infect millions of people a year. To do so, these bacteria depend on a complex network of genes and gene products that allow them to sense environmental conditions.

3 Jan 2023

Zebrafish can provide genetic clues to the evolution of social behaviors in humans, domesticated species

Researchers at Queen Mary University of London have shown that zebrafish can provide genetic baz1b clues to the evolution of social behaviors in humans and domesticated species.

3 Jan 2023

New insights on the circadian clock of Drosophila melanogaster

The higher the temperatures, the faster physiological processes are. But there is an exception: the so-called circadian clock, which regulates the sleep-wake cycle in organisms.

30 Dec 2022

Study reveals protective role of CRTC1 in stopping people from overeating high-calorie foods

High-calorie foods - high in fat, oil, and sugar - can taste good but often cause overeating, leading to obesity and major health problems. But what stimulates the brain to cause overeating?

23 Dec 2022

UC San Diego researchers rewrite the textbook on gene regulation

A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation.

22 Dec 2022

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome - a rare genetic, neurocognitive disorder.

22 Dec 2022

Study increases understanding of the genetic architecture of dementia risk in African ancestry populations

In the largest-ever genetic study of dementia in people of African ancestry, VA researchers identified several genetic risks different from those seen in people of European ancestry.

22 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

Radiation damage to mature sperm cannot be repaired and is instead passed on to the offspring

Whether radiation exposure of fathers can have consequences on their children is one of the most long-standing questions in radiation biology.

21 Dec 2022

Comprehensive lung cell atlas offers insights into an unexpected immune niche in the airways

The most comprehensive lung cell atlas to date, from the Wellcome Sanger Institute and collaborators, has revealed 11 new lung cell types and offers detailed insight into an immune process involved in fighting lung infections.

21 Dec 2022

Huge multi-omic data analysis deciphers colorectal cancer genetics

An analysis of more than 100,000 colorectal cancer cases and 154,000 healthy controls published in Nature Genetics uncovered hundreds of signals that may serve as new treatment and prevention targets.

21 Dec 2022

Research estimates the evolutionary origins of functional human microgenes

Modern humans evolutionarily split from our chimpanzee ancestors nearly 7 million years ago, yet we are continuing to evolve.

20 Dec 2022

Research uncovers a new way to boost the effectiveness of RNA therapies

Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells - cells that control your heartbeat - can "fight back" against therapies to biologically correct abnormal heartbeat rates.

20 Dec 2022

Analysis finds more than 100 new genetic risk factors strongly linked to colorectal cancer

A comprehensive analysis of more than 100,000 colorectal cancer (CRC) cases, led by researchers at the Fred Hutchinson Cancer Center in Seattle and 200 scientific collaborators worldwide, has identified more than 100 new genetic risk factors strongly linked with the disease.

20 Dec 2022

MGI’s DNBSEQ-T7* facilitates ultra-deep sequencing of high-complexity metagenomic samples

Thanks to high-throughput sequencing technologies, shotgun metagenomic methods were made possible and had effectively transformed microbiology. Today, advances in both short- and long-read technologies are overcoming many of the previous challenges affecting metagenomic profiling, especially of highly complex samples and environment.

From MGI 20 Dec 2022

Genomics

Exploring the immune mechanism induced by BCG vaccine in humanized mouse model

Researchers discover new role of small RNAs in Salmonella infections

Zebrafish can provide genetic clues to the evolution of social behaviors in humans, domesticated species

New insights on the circadian clock of Drosophila melanogaster

Study reveals protective role of CRTC1 in stopping people from overeating high-calorie foods

UC San Diego researchers rewrite the textbook on gene regulation

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

Study increases understanding of the genetic architecture of dementia risk in African ancestry populations

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Radiation damage to mature sperm cannot be repaired and is instead passed on to the offspring

Comprehensive lung cell atlas offers insights into an unexpected immune niche in the airways

Huge multi-omic data analysis deciphers colorectal cancer genetics

Research estimates the evolutionary origins of functional human microgenes

Research uncovers a new way to boost the effectiveness of RNA therapies

Analysis finds more than 100 new genetic risk factors strongly linked to colorectal cancer

MGI’s DNBSEQ-T7* facilitates ultra-deep sequencing of high-complexity metagenomic samples

BGI cares - 2022 social responsibilities in review

MGI’s DNBSEQ-T7* recognized for its ultra-high throughput and excellent accuracy

New insights into biophysical origins of the genome's organization inside the cell nucleus

Genome assembly tool could spur the development of new treatments for tuberculosis

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Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

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