Genomics

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Three genetic mutations seen in individuals with KCNMA1-linked channelopathy successfully mirrored in mice

Three genetic alterations associated with a rare seizure and a movement disorder primarily found in children were successfully mirrored in mice and their symptoms treated, in a new study from a University of Maryland School of Medicine researcher, Andrea Meredith, PhD, Professor of Physiology and her collaborators.

15 Aug 2022

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Researchers have created a mathematical model to predict genetic resistance to antimalarial drugs in Africa to manage one of the biggest threats to global malarial control.

12 Aug 2022

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases.

12 Aug 2022

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

12 Aug 2022

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.

11 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

11 Aug 2022

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

10 Aug 2022

Next-generation sequencing system yields results comparable to traditional diagnostics

In the pursuit of accurate diagnoses for illnesses, doctors have traditionally used multiple methods — including culturing patient samples on a wide variety of media, reviewing countless medical records and analyzing clinical data using complex mathematical algorithms — to try to identify the bacterium, virus, fungus or other pathogen responsible for an infection.

10 Aug 2022

Serbia's genome center monitors potential virus mutations to facilitate more effective COVID-19 control

In partnership with BGI Genomics from China, Serbia's first genome sequencing center, opened in December 2021, is monitoring potential virus mutations to facilitate more effective COVID-19 control and accelerating access to genomics to enhance health outcomes.

9 Aug 2022

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Personalized medicine for lung cancer using molecular-targeted drugs is common but there have been no prospective validation studies done on the usefulness of lung cancer gene panel testing using cytology samples.

8 Aug 2022

Sustainable Science; What does the future look like?

We speak to Ali Safavi, CEO and Founder of Grenova about sustainable science, the impact life sciences research is having on our planet, and the solutions they offer for laboratories to help reduce their plastic waste.

From Grenova 8 Aug 2022

New dual-plasmid editing system for DNA-based information rewriting in vivo

DNA-based information is a new interdisciplinary field linking information technology and biotechnology.

5 Aug 2022

Tibbiyah-BGI Almanahil JV will provide highly specialized clinical laboratory testing services

Arabian International Healthcare Holding Company ("Tibbiyah"), a leading integrated healthcare solutions provider in Saudi Arabia, today announced a definitive Joint Venture Agreement with BGI Almanahil Health for Medical Services, a subsidiary company of BGI Health (HK) Co., Ltd, in the formation and operation of a limited liability company to be called Saudi Advanced Medical Lab LIMITED ("SAMLL") in Saudi Arabia.

5 Aug 2022

Baboons at Amboseli offer clues to the costs of the hybridization, study says

New genetic analyses of wild baboons in southern Kenya reveals that most of them carry traces of hybridization in their DNA. As a result of interbreeding, about a third of their genetic makeup consists of genes from another, closely-related species.

5 Aug 2022

Research highlights the crucial role of other living primates as models for understanding human evolution

A new study based in Africa reveals hidden selection against interspecies breeding in wild baboon species in a strikingly similar way to what has been described for archaic hominins. The findings, based on coupled genomic and long-term field data, highlight the crucial role of other living primates as models for understanding human evolution, particularly for phenomena that are impossible to study in our lineage alone.

5 Aug 2022

Genomics

Three genetic mutations seen in individuals with KCNMA1-linked channelopathy successfully mirrored in mice

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

Novel model reveals how genomic instability arises in histologically benign tissue

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

Next-generation sequencing system yields results comparable to traditional diagnostics

Serbia's genome center monitors potential virus mutations to facilitate more effective COVID-19 control

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Sustainable Science; What does the future look like?

New dual-plasmid editing system for DNA-based information rewriting in vivo

Tibbiyah-BGI Almanahil JV will provide highly specialized clinical laboratory testing services

Baboons at Amboseli offer clues to the costs of the hybridization, study says

Research highlights the crucial role of other living primates as models for understanding human evolution

Study reveals the effects of an atypical mode of chromosome arrangement on genome architecture and evolution

Researchers uncover genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Analysis of monkeypox virus genomes suggests that it spread early and cryptically

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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