Genomics

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Researchers use sea anemone to understand how behavior impacts body shape during early development

As humans, we know that an active lifestyle gives us some control over our form. When we hit the pavement, track our steps, and head to the gym, we can maintain muscle development and reduce body fat.

16 Sep 2022

Strains within gut microbial species codiversified with human populations, study finds

Strains within dozens of bacterial species in the gut microbiota codiversified with human populations as they spread across the globe, according to a new study. The findings underscore the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease and microbiota-based therapeutics.

15 Sep 2022

Scientists unravel the molecular origin of rare genetic disease cystinosis

The rare genetic disease cystinosis is caused by mutations in the gene for a protein called cystinosin. A team of scientists has now solved the structure of cystinosin and determined how mutations interfere with its normal function, providing insights into the underlying mechanisms and suggesting a way to develop new treatments for the disease.

15 Sep 2022

COVID-19's future is uncertain as infections increase and tracking decreases

Researchers review how the SARS-CoV-2 genome has changed throughout the COVID-19 pandemic.

14 Sep 2022

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration.

14 Sep 2022

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

In a new study, researchers explored the genetic risk factors associated with various diseases to understand their impact on healthy life years.

14 Sep 2022

Brain organoids shed light into the evolution of the human brain

Animal studies on great apes have long been banned in Europe for ethical reasons. For the question pursued here, so-called organoids, i.e. three-dimensional cell structures a few millimeters in size that are grown in the laboratory, are an alternative to animal experiments.

13 Sep 2022

Scientists estimate the impact of genetic risk factors on the loss of healthy life years

Researchers have, for the first time, systematically estimated the impact of a range of different disease-associated genetic risk factors on the loss of healthy life years. Knowing the contribution of different genetic risk factors on disease burden can help prioritise and design interventions using genetic information.

12 Sep 2022

Jumping gene plays an important role in reducing depression, fear, and anxiety

First characterized in Prof. Tadashi Yamamoto's former lab in Japan in 1996, the gene Tob is well known for the role it plays in cancer. Previous research has also indicated that it has a hand in regulating the cell cycle and the body's immune response.

9 Sep 2022

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Using a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.

9 Sep 2022

NIH funds $3.35 million to enhance diversity in genomics training

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, will fund $3.35 million over five years to launch the Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (GREAT) program.

9 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

9 Sep 2022

New data analysis approach could help uncover the genetic basis of many diseases

In the era of Big Data, obtaining a huge amount of information is the easy part; knowing what to do with it is another story entirely.

9 Sep 2022

A single genomic change may have given modern humans an advantage over Neanderthals

A single amino acid change in the transketolase-like 1 (TKTL1) protein may have given modern humans an advantage over more ancient contemporaries like Neanderthals by enabling increased neocortical neurogenesis, researchers report.

9 Sep 2022

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers.

8 Sep 2022

Researchers identify DNA regions associated with physical activity or leisure screen time

In a large international study, researchers at Uppsala University have identified DNA regions that are associated with physical activity or leisure screen time.

7 Sep 2022

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Did you know that not only does organism's body have a biological clock that can tell the time of the day, it can also tell the time of the year? Now, researchers from Japan have found that one capable little molecule may be behind the mechanism by which the biological clock keeps track of the seasons.

6 Sep 2022

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

The axolotl Ambystoma mexicanum is a popular pet due to its unique and cute appearance. Unlike other salamanders undergoing metamorphosis, axolotls (pronounced ACK-suh-LAH-tuhl) never outgrow their larval, juvenile stage, a phenomenon called neoteny.

6 Sep 2022

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Researchers from Children's Hospital of Philadelphia used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.

6 Sep 2022

Genomics

Researchers use sea anemone to understand how behavior impacts body shape during early development

Strains within gut microbial species codiversified with human populations, study finds

Scientists unravel the molecular origin of rare genetic disease cystinosis

COVID-19's future is uncertain as infections increase and tracking decreases

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

Brain organoids shed light into the evolution of the human brain

Scientists estimate the impact of genetic risk factors on the loss of healthy life years

Jumping gene plays an important role in reducing depression, fear, and anxiety

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

NIH funds $3.35 million to enhance diversity in genomics training

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

New data analysis approach could help uncover the genetic basis of many diseases

A single genomic change may have given modern humans an advantage over Neanderthals

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers identify DNA regions associated with physical activity or leisure screen time

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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