Genomics

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Transcriptomic data reveals the evolutionary relationships of two groups of ancient invertebrates

Kamptozoa and Bryozoa are two phyla of small aquatic invertebrates. They are related to snails and clams (collectively called mollusks), bristleworms, earthworms, and leeches (collectively called annelids), and ribbon worms (nemertea).

1 Jul 2022

New, safer CRISPR approach may help correct genetic defects in the future

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the safety of these new methods is still of significant concern.

1 Jul 2022

Chemical-based sequencing method to efficiently study DNA methylation

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off.

1 Jul 2022

Scientists use single cell techniques to uncover a central dichotomy for colorectal cancer cells

A team of clinician-scientists and scientists, led by the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore together with collaborators in Europe and South Korea, used single-cell techniques to uncover a central dichotomy for colorectal cancer cells, leading to a proposed update of the classification system for the disease.

1 Jul 2022

Researchers uncover a novel interplay between coral pathogen and other coral commensal bacteria

Coral is a complicated holobiont, harboring an array of life forms at different scales, including coral cells, zooxanthellae, and associated bacteria, archaea, and viruses.

1 Jul 2022

New study investigates the epigenetic drift of time passing

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, "Time makes histone H3 modifications drift in mouse liver."

30 Jun 2022

Rice lab’s microbial community profiling software effectively identifies bacterial species

Part of a gene is better than none when identifying a species of microbe. But for Rice University computer scientists, part was not nearly enough in their pursuit of a program to identify all the species in a microbiome.

30 Jun 2022

HKUMed researchers discover more efficient CRISPR-Cas9 variants for gene therapy applications

A research team from the LKS Faculty of Medicine, The University of Hong Kong discovered more efficient CRISPR-Cas9 variants that could be useful for gene therapy applications.

30 Jun 2022

New approaches for getting and maximizing usable DNA from decades-old pickled specimens

Two levels underground, Chicago's Field Museum has a secret bunker. The sub-basement Collections Resource Center houses millions of biological specimens for scientists around the world to use in their research, including countless bottles and jars containing pickled fish, lizards, and snakes, arranged like a library.

30 Jun 2022

Online version of algorithm shows how biases in RNA sequences affect gene expression

A recent publication from researchers at the University of Kentucky explains the importance of identifying and understanding how differences between tissues and cells alter gene expression without changing the underlying genetic code.

29 Jun 2022

NUS researchers discover a new way to interpret unsolved Mendelian diseases

The development of an embryo is a well-orchestrated string of processes, ensuring correct formation and positioning of vital organs of the growing organism.

29 Jun 2022

Just like magic; automated solutions for NGS library preparation

As part of our SLAS Europe 2022 coverage, we speak to Ian Shuttler from Tecan about their new MagicPrepTM NGS technology.

From Tecan 29 Jun 2022

Duke researchers identify role for key gene in developmental disability syndrome

A single gene that was previously found to be the driving force in a rare syndrome linked to epilepsy, autism and developmental disability has been identified as a linchpin in the formation of healthy neurons.

28 Jun 2022

New machine learning method may improve the identification of genes that cause diseases

A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.

28 Jun 2022

New technique offers higher-precision scRNA-seq data than current technologies

The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized the fields of medicine and biology by providing the ability to study the inner workings of thousands of cells at one go.

28 Jun 2022

Using genomics to restore degraded ecosystems

The monumental global task to restore degraded ecosystems will need to include sophisticated technologies such as environmental DNA monitoring to understand and support the recovery of complex biospheres, international researchers say.

27 Jun 2022

New nanoparticles effectively stopped the growth and spread of ovarian, liver tumors in mice

As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult.

24 Jun 2022

"Founder events" that reduced genetic diversity found to be common throughout human history

Human populations have waxed and waned over the millennia, with some cultures exploding and migrating to new areas or new continents, others dropping to such low numbers that their genetic diversity plummeted.

23 Jun 2022

New method helps unravel three-dimensional structure of the human genome

Weill Cornell Medicine and New York Genome Center researchers, in collaboration with Oxford Nanopore Technologies, have developed a new method to assess on a large scale the three-dimensional structure of the human genome, or how the genome folds.

23 Jun 2022

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Results of a study of molecular tumor profiling in young patients revealed a high rate of genetic alterations with potential for impacting clinical care, including clarifying diagnoses and treatment with matched, precision cancer drugs.

23 Jun 2022

Genomics

Transcriptomic data reveals the evolutionary relationships of two groups of ancient invertebrates

New, safer CRISPR approach may help correct genetic defects in the future

Chemical-based sequencing method to efficiently study DNA methylation

Scientists use single cell techniques to uncover a central dichotomy for colorectal cancer cells

Researchers uncover a novel interplay between coral pathogen and other coral commensal bacteria

New study investigates the epigenetic drift of time passing

Rice lab’s microbial community profiling software effectively identifies bacterial species

HKUMed researchers discover more efficient CRISPR-Cas9 variants for gene therapy applications

New approaches for getting and maximizing usable DNA from decades-old pickled specimens

Online version of algorithm shows how biases in RNA sequences affect gene expression

NUS researchers discover a new way to interpret unsolved Mendelian diseases

Just like magic; automated solutions for NGS library preparation

Duke researchers identify role for key gene in developmental disability syndrome

New machine learning method may improve the identification of genes that cause diseases

New technique offers higher-precision scRNA-seq data than current technologies

Using genomics to restore degraded ecosystems

New nanoparticles effectively stopped the growth and spread of ovarian, liver tumors in mice

"Founder events" that reduced genetic diversity found to be common throughout human history

New method helps unravel three-dimensional structure of the human genome

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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