Histology & Microscopy

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Study reveals the spatial connectivity patterns of mouse hippocampal neurons

A study published in Science on Feb. 1 reported a comprehensive database of single-neuron projectomes consisting of over 10,000 mouse hippocampal neurons, thus revealing the spatial connectivity patterns of mouse hippocampal neurons at the mesoscopic level.

2 Feb 2024

Scientists discover orderly structure hidden within bacterial biofilms

Bacteria are traditionally imagined as single-cell organisms, spread out sparsely over surfaces or suspended in liquids, but in many environments the true bacterial mode of growth is in sticky clusters called biofilms.

2 Feb 2024

Yokogawa introduces CellVoyager High-Content Analysis System CQ3000

The CQ3000 will be showcased at SLAS2024 Boston, MA, February 3-7 with live on-booth demonstrations (booth #485)

From Yokogawa Life Science 2 Feb 2024

New microscopy technology unveils detailed images of brain cancer tissue

Brigham and MIT researchers uncovered never-before-seen details in human brain tissue with new, inexpensive microscopy technology.

1 Feb 2024

Scientists demonstrate way to produce SARS-CoV-2 receptor protein in mouse cells

A team of scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Columbia University has demonstrated a way to produce large quantities of the receptor that SARS-CoV-2, the virus that causes COVID-19, binds to on the surface of human cells.

22 Jan 2024

New technique provides an unprecedented view inside the cell's control center

The cell nucleus is considered to be the control center of vital cellular processes, but its material properties continue to puzzle scientists.

18 Jan 2024

Bacterial "freight elevator" unpacked: How pathogens hide from the immune system

Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane.

8 Jan 2024

Cytonemes: The "express subways" of the developing nervous system

St. Jude Children's Research Hospital scientists found that cytonemes (thin, long, hair-like projections on cells) are important during neural development.

3 Jan 2024

Research reveals how "forever chemicals" damage DNA at the molecular level

Recent research published in the journal Eco-Environment & Health (Volume 2, 2023) reveals groundbreaking insights into how typical PFAAs accelerate the degradation of DNA.

26 Dec 2023

Study reveals how tiny tweaks to actin shape our cells

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin.

22 Dec 2023

Early embryo DNA replication program reveals unexpected flexibility

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next.

20 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Study tracks evolution of deadly chicken virus using ancient DNA

An international team of scientists led by geneticists and disease biologists from the University of Oxford and LMU Munich have used ancient DNA to trace the evolution of Marek's Disease Virus (MDV).

15 Dec 2023

Advanced imaging technique reveals the high-resolution structure of cyanobacterial virus

A research team at the Hong Kong University of Science and Technology (HKUST) has outlined the high-resolution structure of a little-known virus, improving our understanding of viral infection, which could pave the way for more accurate predictions of climate change.

14 Dec 2023

Scientists unveil 3D structure of key immune system component

An international team of researchers from LMU and the Helmholtz Centre for Infection Research has visualized the structure of the so-called ASC speck.

8 Dec 2023

New insights into the structures formed during antibody aggregation through 3D domain swapping

Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development.

8 Dec 2023

New discovery unveils an additional layer of the CRISPR-Cas antiviral defense system

The recent publication in Science by Mogila, Tamulaitiene et al. represents a continuation of the successful scientific research conducted by Gintautas Tamulaitis' group.

4 Dec 2023

New molecular rulers for super-resolution microscopy: A breakthrough in biological imaging

Latest super-resolution microscopy methods now achieve an optical resolution in the range of a few nanometers.

1 Dec 2023

Novel AI-powered method detects antimicrobial resistance within 30 minutes

To mark World Antimicrobial Awareness Week, researchers supported by the Oxford Martin Programme on Antimicrobial Resistance Testing (University of Oxford) have reported advances towards a novel and rapid antimicrobial susceptibility test that can return results within as little as 30 minutes.

22 Nov 2023

CÚRAM researchers make breakthrough in cell visualization

CÚRAM researchers at University of Galway, together with colleagues at the Centre for Molecular Nanometrology at University of Strathclyde have published work unveiling the inner workings of cells.

10 Nov 2023