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Chemical disruption to key interaction shown to limit metastasis in test mice

Finding ways to counteract or disrupt the invasive nature of cancer cells, called "metastasis," has been a long-term goal of cancer researchers. Now, researchers at Moffitt Cancer Center in Tampa, Fla., have identified an interactive pathway that regulates metastases in some cancers that may be vulnerable to chemical targeting in order to prevent cancer cell proliferation and tumor growth.

14 Dec 2011

$Celgene reports final results from REVLIMID-rituximab combination phase II study for relapsed/refractory CLL$

Celgene reports final results from REVLIMID-rituximab combination phase II study for relapsed/refractory CLL

Celgene International Sàrl, a subsidiary of Celgene Corporation, (NASDAQ: CELG), announced final results from a phase II investigational study evaluating the combination of REVLIMID® (lenalidomide) and rituximab in 59 patients with relapsed or refractory chronic lymphocytic leukemia (CLL). These data were presented at the 53rd Annual Meeting of the American Society of Hematology in San Diego, CA.

14 Dec 2011

Research on pancreatic cancer diagnostic test wins QED award

Hwyda Arafat, M.D., Ph.D., Associate Professor of Surgery at Thomas Jefferson University and co-director of the Jefferson Pancreatic, Biliary and Related Cancers Center, and Mon-Li Chu, Ph.D., Professor and Vice Chair of the Department of Dermatology and Cutaneous Biology, were awarded $200,000 from the University City Science Center's QED Proof of Concept Program for their breakthrough work on a diagnostic test for pancreatic cancer.

14 Dec 2011

Textile cushions with smart sensor systems for persons confined to bed or wheelchair

Anyone confined to a wheelchair or a bed has to deal with numerous complications. Frequently, they suffer from bedsores or decubitus ulcers as physicians call them. Bony prominences, such as the sacrum, coccyx and ischium, are especially endangered spots. Unrelieved pressure can lead to tissue necrosis. Damage can extend into the periosteum and, at the worst, into bones themselves.

14 Dec 2011

Hydrogel regenerates healthy, scar-free tissue on skin damaged by severe burns

Johns Hopkins researchers have developed a jelly-like material and wound treatment method that, in early experiments on skin damaged by severe burns, appeared to regenerate healthy, scar-free tissue.

14 Dec 2011

Potential nanoparticle treatment for macular degeneration and retinitis pigmentosa

Hitching a ride into the retina on nanoparticles called dendrimers offers a new way to treat age-related macular degeneration and retinitis pigmentosa. A collaborative research study among investigators at Wayne State University, the Mayo Clinic and Johns Hopkins Medicine shows that steroids attached to the dendrimers targeted the damage-causing cells associated with neuroinflammation, leaving the rest of the eye unaffected and preserving vision.

14 Dec 2011

Positive data from Nektar's NKTR-181 Phase 1 clinical study for chronic pain

Nektar Therapeutics today announced positive data from a Phase 1 clinical study of NKTR-181 evaluating multiple ascending oral doses of NKTR-181 over an 8-day treatment period in healthy subjects.

14 Dec 2011

Acetylcholine can weaken synaptic connections between neurons in brain

Researchers from the University of Bristol have discovered that a chemical compound in the brain can weaken the synaptic connections between neurons in a region of the brain important for the formation of long-term memories.

14 Dec 2011

Researchers discover how statins promote breakdown of plaque in arteries

In a new study, NYU Langone Medical Center researchers have discovered how cholesterol-lowering drugs called statins promote the breakdown of plaque in the arteries. The study was published online by the journal PLoS One on December 6, 2011.

14 Dec 2011

People with Parkinson's exhibit increased arm swing during early stages

People with Parkinson's disease swing their arms asymmetrically -- one arm swings less than the other -- when walking. This unusual movement is easily detected early when drugs and other interventions may help slow the disease, according to Penn State researchers who used inexpensive accelerometers on the arms of Parkinson's disease patients to measure arm swing.

14 Dec 2011

Link between high tau levels and worse outcome after head trauma

High levels of tau protein in fluid bathing the brain are linked to poor recovery after head trauma, according to a study from Washington University School of Medicine in St. Louis and the Fondazione IRCCS Ca Granda-Ospedale Maggiore Policlinico in Milan, Italy.

14 Dec 2011

Study: High cancer screening rates seen among elderly adults

Adults older than 75 years continue to have regular screenings for colorectal, breast, cervical, and prostate cancer despite guidelines that recommend against such routine screenings in this population, according to a study by Keith M. Bellizzi, MD, MPH, from the University of Connecticut, Storrs, and colleagues.

14 Dec 2011

Researchers uncover important source of inflammation for CKD

UC Irvine researchers have uncovered an important source of inflammation seen in people with chronic kidney disease, which is increasingly common due to the epidemic of obesity-related diabetes and hypertension.

14 Dec 2011

Celgene announces data from REVLIMID Phase III study on high-risk asymptomatic smoldering MM

Celgene International Sàrl, a subsidiary of Celgene Corporation, announced that updated data evaluating continuous treatment with REVLIMID (lenalidomide) in patients with high-risk asymptomatic smoldering multiple myeloma were presented at the 53rd Annual Meeting of the American Society of Hematology.

14 Dec 2011

Maraviroc reduces incidence of GvHD in blood cancer patients after ASCT

An HIV drug that redirects immune cell traffic appears to significantly reduce the dangerous complication graft-versus-host disease (GvHD) in blood cancer patients following allogeneic stem cell transplantation (ASCT), according to new research from the Perelman School of Medicine at the University of Pennsylvania that will be presented today at the 53rd American Society of Hematology Annual Meeting.

14 Dec 2011

New study: Insulin signaling is altered in human pancreas

Insulin signaling is altered in the pancreas, a new study shows for the first time in humans. The errant signals disrupt both the number and quality of beta cells - the cells that produce insulin.

14 Dec 2011

RHUL researchers call for more unified lower back pain guidelines

Researchers at Royal Holloway, University of London are calling for more unified guidelines about returning back pain patients to work as currently the advice can be contradictory and confusing.

14 Dec 2011

ACS revises guideline formation process for cancer screening

The American Cancer Society has revised its guideline formation process to achieve greater transparency, consistency, and rigor in creating guidance about cancer screening.

14 Dec 2011

Children of childhood cancer survivors do not have increased risk for birth defects

A large, retrospective study of the children of childhood cancer survivors who were treated with radiation therapy and/or some forms of chemotherapy found that the offspring do not have an increased risk for birth defects compared to children of cancer survivors who did not receive such treatments.

14 Dec 2011

Promising results from Fate Therapeutics' ProHema Phase 1b trial on hematologic malignancies

Fate Therapeutics, Inc. announced today promising clinical results from a Phase 1b trial of ProHema (FT1050-enhanced umbilical cord blood) as part of double-umbilical cord blood (UCB) transplants in adult patients with hematologic malignancies who have undergone reduced-intensity conditioning therapy.

14 Dec 2011