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DCC gene protects mice from onset of colon cancer

The research team at Lyon has developed an animal model carrying a mutation of the DCC gene. Mice carrying the mutation develop tumours, because this gene can no longer induce the death of the cancer cells. This discovery could lead to the development of a new targeted cancer treatment that aims to reactivate the dying of cancer cells.

15 Dec 2011

Magnetic stimulation of brain nerve cells may speed up recovery from hemispatial neglect

Imagine waking up and being unable to see or recognize anything on the left side of your body. This condition, called hemispatial neglect, is common after a stroke that occurs on the right side of the brain. The current treatment of attention and concentration training using computer and pencil-and-paper tasks is inadequate.

15 Dec 2011

Thousands of diabetes-related deaths could be avoided with better care: UK Report

According to a new report up to 24,000 diabetes-related deaths could be avoided in England each year, if patients and doctors better managed the condition. This is the first-ever audit of patient deaths from diabetes. It says that basic health checks, a good diet and regular medication could prevent most of the deaths.

15 Dec 2011

Ganitumab shows promise in early-phase trials for metastatic pancreatic cancer

Over 17,000 patients will have been diagnosed with locally-advanced pancreatic cancer in the United States in 2011. Surgery is not a treatment option for these patients whose tumor has grown beyond the pancreas to surrounding vital structures.

15 Dec 2011

Researchers develop mouse model to investigate fenugreek allergy

A mouse model to investigate allergy to fenugreek has been developed by Norwegian researchers. The model can also be used to study cross-reactivity to peanut, soy and lupin, major food allergens with public health relevance.

15 Dec 2011

Attention deficit drugs safe for adult hearts as well

A new study looked at nearly 150,000 adults taking drugs for attention deficit hyperactivity disorder (ADHD) and found that the medications do not increase the risk for heart attack, stroke, or sudden death from heart-related causes.

15 Dec 2011

Antioxidant can delay onset of all indicators of Alzheimer's

When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down. Simply put, that same "browning" process-known as oxidative stress-happens in the brain as Alzheimer's disease sets in. The underlying cause is believed to be improper processing of a protein associated with the creation of free radicals that cause oxidative stress.

15 Dec 2011

Novel prognostic model for patients with treatment-related MDS

A large-scale analysis of patients whose myelodysplastic syndrome is related to earlier cancer treatment overturns the notion that all of them have a poor prognosis, researchers from The University of Texas MD Anderson Cancer Center report at the 53rd Annual Meeting of the American Society of Hematology.

15 Dec 2011

Molecular signature indicative of hypoxia predicts progression to AD

A study led by Research Professor Matej Ore-ič from VTT Technical Research Centre of Finland suggests that Alzheimer's disease is preceded by a molecular signature indicative of hypoxia and up-regulated pentose phosphate pathway.

15 Dec 2011

Dendrimers offers a new way to treat age-related macular degeneration, retinitis pigmentosa

Hitching a ride into the retina on nanoparticles called dendrimers offers a new way to treat age-related macular degeneration and retinitis pigmentosa. A study by investigators at Mayo Clinic, Wayne State University and Johns Hopkins Medicine shows that steroids attached to the dendrimers target the damage-causing cells associated with neuroinflammation, leaving the rest of the eye unaffected and preserving vision.

14 Dec 2011

Chronic fatigue syndrome may be reason behind many school absenteeism: Study

According to a new study one in 100 secondary school pupils could be missing classes because of chronic fatigue syndrome, also known as Myalgic Encephalomyelitis (ME). A study following 2,855 pupils at three schools, published in the online journal BMJ Open, found 28 missed school with chronic fatigue syndrome.

14 Dec 2011

Salix submits Crofelemer NDA to FDA for treatment of HIV-associated diarrhea

Salix Pharmaceuticals, Ltd. today announced that the Company has submitted to the U.S. Food and Drug Administration (FDA) a New Drug Application (NDA) for Crofelemer for the proposed treatment of HIV-associated diarrhea.

14 Dec 2011

Angioplasties can be safely performed at centers that do not have on-site surgical capability

Contrary to current guidelines, Mayo Clinic researchers have found that elective or primary (in patients who have had heart attacks) angioplasties performed at centers without on-site cardiac surgery capabilities pose no increased risk for patient death or emergency bypass surgery.

14 Dec 2011

H2S plays critical role in signaling pathway linked to Alzheimer's and Parkinson's

Something rotten never smelled so sweet. This is what members of a team of scientists at Cold Spring Harbor Laboratory (CSHL) are telling one another as they discuss a new finding they did not expect to make. They have discovered that hydrogen sulfide (H2S) - the flammable, highly toxic gas that we usually associate with the smell of rotten eggs in landfills and sewers - plays an important role in the regulation of a signaling pathway implicated in biological malfunctions linked to Alzheimer's and Parkinson's diseases, among others.

14 Dec 2011

Chemical disruption to key interaction shown to limit metastasis in test mice

Finding ways to counteract or disrupt the invasive nature of cancer cells, called "metastasis," has been a long-term goal of cancer researchers. Now, researchers at Moffitt Cancer Center in Tampa, Fla., have identified an interactive pathway that regulates metastases in some cancers that may be vulnerable to chemical targeting in order to prevent cancer cell proliferation and tumor growth.

14 Dec 2011

$Celgene reports final results from REVLIMID-rituximab combination phase II study for relapsed/refractory CLL$

Celgene reports final results from REVLIMID-rituximab combination phase II study for relapsed/refractory CLL

Celgene International Sàrl, a subsidiary of Celgene Corporation, (NASDAQ: CELG), announced final results from a phase II investigational study evaluating the combination of REVLIMID® (lenalidomide) and rituximab in 59 patients with relapsed or refractory chronic lymphocytic leukemia (CLL). These data were presented at the 53rd Annual Meeting of the American Society of Hematology in San Diego, CA.

14 Dec 2011

Research on pancreatic cancer diagnostic test wins QED award

Hwyda Arafat, M.D., Ph.D., Associate Professor of Surgery at Thomas Jefferson University and co-director of the Jefferson Pancreatic, Biliary and Related Cancers Center, and Mon-Li Chu, Ph.D., Professor and Vice Chair of the Department of Dermatology and Cutaneous Biology, were awarded $200,000 from the University City Science Center's QED Proof of Concept Program for their breakthrough work on a diagnostic test for pancreatic cancer.

14 Dec 2011

Textile cushions with smart sensor systems for persons confined to bed or wheelchair

Anyone confined to a wheelchair or a bed has to deal with numerous complications. Frequently, they suffer from bedsores or decubitus ulcers as physicians call them. Bony prominences, such as the sacrum, coccyx and ischium, are especially endangered spots. Unrelieved pressure can lead to tissue necrosis. Damage can extend into the periosteum and, at the worst, into bones themselves.

14 Dec 2011

Hydrogel regenerates healthy, scar-free tissue on skin damaged by severe burns

Johns Hopkins researchers have developed a jelly-like material and wound treatment method that, in early experiments on skin damaged by severe burns, appeared to regenerate healthy, scar-free tissue.

14 Dec 2011

Potential nanoparticle treatment for macular degeneration and retinitis pigmentosa

Hitching a ride into the retina on nanoparticles called dendrimers offers a new way to treat age-related macular degeneration and retinitis pigmentosa. A collaborative research study among investigators at Wayne State University, the Mayo Clinic and Johns Hopkins Medicine shows that steroids attached to the dendrimers targeted the damage-causing cells associated with neuroinflammation, leaving the rest of the eye unaffected and preserving vision.

14 Dec 2011

Medical Condition News

DCC gene protects mice from onset of colon cancer

Magnetic stimulation of brain nerve cells may speed up recovery from hemispatial neglect

Thousands of diabetes-related deaths could be avoided with better care: UK Report

Ganitumab shows promise in early-phase trials for metastatic pancreatic cancer

Researchers develop mouse model to investigate fenugreek allergy

Attention deficit drugs safe for adult hearts as well

Antioxidant can delay onset of all indicators of Alzheimer's

Novel prognostic model for patients with treatment-related MDS

Molecular signature indicative of hypoxia predicts progression to AD

Dendrimers offers a new way to treat age-related macular degeneration, retinitis pigmentosa

Chronic fatigue syndrome may be reason behind many school absenteeism: Study

Salix submits Crofelemer NDA to FDA for treatment of HIV-associated diarrhea

Angioplasties can be safely performed at centers that do not have on-site surgical capability

H2S plays critical role in signaling pathway linked to Alzheimer's and Parkinson's

Chemical disruption to key interaction shown to limit metastasis in test mice

Celgene reports final results from REVLIMID-rituximab combination phase II study for relapsed/refractory CLL

Research on pancreatic cancer diagnostic test wins QED award

Textile cushions with smart sensor systems for persons confined to bed or wheelchair

Hydrogel regenerates healthy, scar-free tissue on skin damaged by severe burns

Potential nanoparticle treatment for macular degeneration and retinitis pigmentosa

This International Women’s Day, Meet the Scientist Changing Women’s Healthcare

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

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