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Common genetic variant may predispose people to acute dissections

Richard Holbrooke, John Ritter, Lucille Ball, Jonathan Larson and Great Britain's King George II were all taken by the same silent killer: an acute aortic dissection. Now, scientists led by researchers at The University of Texas Health Science Center at Houston and Baylor College of Medicine have found an association with a common genetic variant in the population that predisposes people to acute dissections and can approximately double a person's chances of having the disease.

12 Sep 2011

Scientists identify 28 blood pressure-associated genetic variants

A new report from scientists at Massachusetts General Hospital (MGH) and their colleagues in centers around the world finds that common variants in 28 regions of DNA are associated with blood pressure in human patients.

12 Sep 2011

Febrile seizures in children may be linked to respiratory alkalosis

New research shows that febrile seizures in children may be linked to respiratory alkalosis, indicated by elevated blood pH and low carbon dioxide levels caused by hyperventilation, and independent of the underlying infection severity.

12 Sep 2011

Researchers identify 29 DNA sequence variations linked with blood pressure

A study involving more than 200,000 people worldwide has identified 29 DNA sequence variations in locations across the human genome that influence blood pressure.

12 Sep 2011

Study: Regional differences exist in treatment of patients with acute cerebral infarction

Considerable regional differences exist in the treatment of patients with acute cerebral infarction. This is the finding presented by Erwin Stolz and his co-authors in the current issue of Deutsches Ärzteblatt International.

12 Sep 2011

Australian scientists create iron-rich 'super rice'

Scientists from three universities in South Australia and the University of Melbourne have created genetically modified rice that "has up to four times more iron than conventional rice and twice as much zinc" in an effort to "provide a solution to the iron and zinc deficiency disorders that affect billions of people throughout the world," News Corp Australian Papers/Fox News reports.

12 Sep 2011

NIH awards $13M grant to BMC for brain abnormality study in former ELGANS

Researchers and clinicians from Boston Medical Center (BMC) have been awarded a four year, more than $13 million grant from the National Institutes of Health (NIH) to study neurological and brain abnormalities in former extremely low gestational age newborns.

12 Sep 2011

Researchers discover 16 new gene regions that influence blood pressure

Findings, published today in Nature and Nature Genetics by the International Consortium for Blood Pressure Genome-Wide Association Studies represent a major advance in our understanding of the inherited influences on blood pressure and offer new potential therapeutic targets for prevention of heart disease and stroke - the biggest cause of death worldwide.

12 Sep 2011

NASA selects nine projects to investigate space radiation's effect on human explorers

NASA is funding nine proposals from eight states to investigate space radiation's effect on human explorers. The proposals from researchers in California, Colorado, Florida, Georgia, Maryland, Massachusetts, New York and Texas have a total value of approximately $12 million.

12 Sep 2011

Study pinpoints relationship between primary brain tumors and onset of epileptic seizures

New research from the University of Alabama at Birmingham pinpoints the relationship between primary brain tumors and the onset of epileptic seizures and reveals that a drug used to treat Crohn's disease inhibits those seizures and may be able to slow a tumor's growth.

12 Sep 2011

Nektar announces positive results from NKTR-102 Phase 2 study on metastatic breast cancer

Nektar Therapeutics announced today that positive results from the company's Phase 2 clinical study of NKTR-102 in patients with metastatic breast cancer were presented at the ASCO 2011 Breast Cancer Symposium in San Francisco, California.

12 Sep 2011

Researchers demonstrate connection between circadian rhythm, platelet function and cardiovascular risk

Researchers at Brigham and Women's Hospital (BWH) have demonstrated that the circadian system, the body's internal clock, regulates human platelet function and causes a peak in platelet activation corresponding to the known morning peak in adverse cardiovascular events. These findings are published in PLoS ONE on September 8, 2011.

9 Sep 2011

Moffitt researchers employ LC-MRM to detect acquired multiple myeloma drug resistance

"Acquired drug resistance" (ADR) is a major problem encountered in treating some forms of cancer. The ability to monitor the proteins involved in drug resistance has been a hurdle facing cancer researchers. However, a team of researchers at Moffitt Cancer Center, and colleagues, are pioneering promising research utilizing a monitoring technology that could provide a better understanding of ADR and assist in clinical decision-making for developing individualized patient treatments for multiple myeloma.

9 Sep 2011

NIH awards $12.8 million renewal grant for Louisville adult stem cell research project

At the time when Dr. Roberto Bolli received word that he was awarded a $12.8 million grant renewal from the National Institutes of Health for one research project, five patients in another of his clinical trials at the University of Louisville have reached the successful endpoint of their participation.

9 Sep 2011

Researchers create powerful anti-diabetic prototype drugs with lesser side effects

Researchers from Dana-Farber Cancer Institute in Boston and the Scripps Research Institute in Jupiter, Fla., report they have created prototype drugs having powerful anti-diabetic effects, yet apparently free - at least in mice - of dangerous side effects plaguing some current diabetes medications.

9 Sep 2011

Autophagy also mobilizes and exports cholesterol from cells

Researchers at the University of Ottawa Heart Institute (UOHI) have discovered that an ancient pathway called autophagy also mobilizes and exports cholesterol from cells.

9 Sep 2011

Landmark discovery in rapid spread of PRL-3 oncoprotein associated aggressive cancers

Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have made a landmark discovery in the battle against the rapid spread of aggressive cancers associated with PRL-3 oncoprotein.

9 Sep 2011

Ultrasonic neuromodulation can be quickly applied in neurocritical care situations

The discovery that low-intensity, pulsed ultrasound can be used to noninvasively stimulate intact brain circuits holds promise for engineering rapid-response medical devices.

9 Sep 2011

Tics are not a rare or uncommon disorder

Experts have confirmed it: tics are not a rare or uncommon disorder. It is the second study to be conducted in Spain to date, and the first of great importance, revealing that the prevalence of these motor disorders in the child population is 16.86%. The incidence is greater in boys than girls, and they tend to disappear or reduce with age.

9 Sep 2011

U.N. member states reach tentative agreement on NCD declaration

U.N. member state representatives recently reached an agreement "on a political declaration document for the 19 September U.N. high-level meeting on the prevention and control of non-communicable diseases (NCDs)," although the document is "somewhat watered down from an original version," ScienceInsider reports (Reardon, 9/7).

9 Sep 2011

Medical Condition News

Common genetic variant may predispose people to acute dissections

Scientists identify 28 blood pressure-associated genetic variants

Febrile seizures in children may be linked to respiratory alkalosis

Researchers identify 29 DNA sequence variations linked with blood pressure

Study: Regional differences exist in treatment of patients with acute cerebral infarction

Australian scientists create iron-rich 'super rice'

NIH awards $13M grant to BMC for brain abnormality study in former ELGANS

Researchers discover 16 new gene regions that influence blood pressure

NASA selects nine projects to investigate space radiation's effect on human explorers

Study pinpoints relationship between primary brain tumors and onset of epileptic seizures

Nektar announces positive results from NKTR-102 Phase 2 study on metastatic breast cancer

Researchers demonstrate connection between circadian rhythm, platelet function and cardiovascular risk

Moffitt researchers employ LC-MRM to detect acquired multiple myeloma drug resistance

NIH awards $12.8 million renewal grant for Louisville adult stem cell research project

Researchers create powerful anti-diabetic prototype drugs with lesser side effects

Autophagy also mobilizes and exports cholesterol from cells

Landmark discovery in rapid spread of PRL-3 oncoprotein associated aggressive cancers

Ultrasonic neuromodulation can be quickly applied in neurocritical care situations

Tics are not a rare or uncommon disorder

U.N. member states reach tentative agreement on NCD declaration

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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