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Semaphorin-PlexinD1 signaling pathway shows promise as therapeutic target for cancer treatment

In a new study published in the August 16th issue of Developmental Cell, researchers at NYU Langone Medical Center identified a molecular mechanism that guarantees that new blood vessels form in the right place and with the proper abundance.

17 Aug 2011

High parity linked with increased risk of ER-/PR- breast cancer

Investigators from the Boston University's Slone Epidemiology Center have reported findings that may shed light on why African American women have a disproportionately higher risk of developing more aggressive and difficult-to-treat breast cancers, specifically estrogen and progesterone receptor negative (ER-/PR-) cancers.

17 Aug 2011

OrbusNeich's Genous Stent safe, effective for patients at high risk of restenosis

OrbusNeich today announced that the that the company's Genous Stent showed no significant difference in the rate of target vessel failure (TVF) at two years compared to the Taxus Liberte™ paclitaxel-eluting stent in patients with de novo coronary artery lesions carrying a high risk for restenosis.

17 Aug 2011

U-M's epilepsy surgery could successfully treat patients with seizures

John Ligerakis was told he had to learn to live with seizures that had made it challenging for him to work or drive a car. A young professional just starting his career, Ligerakis was devastated about what his future might bring.

17 Aug 2011

New tool can identify patients at high risk of venous thromboembolism

A new risk prediction tool can identify patients at high risk of serious blood clots (known as venous thromboembolism) who might need preventative treatment, says a study published on bmj.com today.

17 Aug 2011

Amphibian skin secretions can reveal amazing medicinal properties

Frogs place in culture ranges from the wise, to the prince in disguise. But it's the idea that a frog can produce life-saving medicine that's currently the subject of an international research project involving Professor Chris Shaw and colleagues at Queen's University Belfast, in Northern Ireland. They have discovered proteins in frog skins that could be used to treat cancer, diabetes, strokes and transplant patients by regulating the growth of blood vessels.

17 Aug 2011

UCSD Sulpizio Cardiovascular Center receives ACCF/AHA's GWTG Gold award

UC San Diego Health System is one of only 167 hospitals nationwide to receive the American College of Cardiology Foundation's (ACCF) NCDR ACTION Registry-GWTG (Get with the Guidelines) Gold Performance Achievement Award for 2011.

17 Aug 2011

Pegloticase can improve clinical outcomes of patients with chronic gout

Injections of pegloticase, a modified porcine enzyme, can produce significant and sustained clinical improvements in 2 out of 5 patients with chronic gout that is resistant to conventional therapies, researchers report in the August 17, 2011, issue of JAMA.

17 Aug 2011

Study finds large variation in reoperation rates after colorectal surgery in England

There is a large variation in unplanned reoperation rates after colorectal surgery in English NHS hospitals, finds a study published on bmj.com today.

17 Aug 2011

Patient navigators can help eliminate cancer health disparities

Past research shows that minorities suffer higher rates of advanced cancer and deaths from all types of cancer compared to whites. According to an article in the August issue of Cancer, the role of "patient navigator" is emerging as a tool to address these disparities.

17 Aug 2011

New research: Blood stem cells can be involved in pathogenesis of CLL

New research suggests that blood stem cells can be involved in the generation of leukemia, even when the leukemia is caused by the abnormal proliferation of mature cells. The study, published by Cell Press in the August 16th issue of the journal Cancer Cell, may guide future strategies aimed at identifying therapeutic targets for chronic lymphocytic leukemia.

17 Aug 2011

Drug SLM3 prevents multiplication of tumor cells

Tumors that do not respond to chemotherapy are the target of a cancer therapy that prevents the function of two enzymes in mouse tumor cells, according to Pennsylvania medical researchers.

17 Aug 2011

Study: Vitamin D directly terminates production of MS-causing protein

While for years scientists have noted an association between levels of vitamin D in a person's body and the person's ability to resist or minimize the effects of multiple sclerosis (MS), the mechanism involved has not been established.

17 Aug 2011

Alcohol and impulsivity are a dangerous mix

Alcohol and impulsivity are a dangerous mix: People with current drinking problems and poor impulse control are more likely to die in the next 15 years, a new study suggests. However, they could get by with a little help from their friends: The study also found that a strong social support network buffers the toxic effects of impulsivity.

17 Aug 2011

PTSD impairs ability to recognize emotions from facial expressions

Facial expressions convey strong cues for someone's emotional state and the ability to interpret these cues is crucial in social interaction. This ability is known to be compromised in many psychiatric and neurological disorders, such as social anxiety or Korsakoff's syndrome.

17 Aug 2011

FDA clears Inhibikase IkT-001 Phase II trial to treat JCV infection in multiple sclerosis patients

Inhibikase Therapeutics, Inc., an emerging leader in infectious disease, announced today that it has received FDA clearance to commence a Phase II proof-of-concept trial for its lead compound IkT-001. IkT-001, a host-directed kinase inhibitor, is intended to clear JC polyomavirus (JCV) infection, the causative agent of Progressive Multifocal Leukoencephalopathy (PML).

17 Aug 2011

Moderate social drinking reduces risk of dementia and cognitive impairment

Moderate social drinking significantly reduces the risk of dementia and cognitive impairment, according to an analysis of 143 studies by Loyola University Chicago Stritch School of Medicine researchers.

17 Aug 2011

Obesity directly causes electrical abnormalities of the heart

University of Adelaide research has shown for the first time that obesity directly causes electrical abnormalities of the heart.

17 Aug 2011

WSU researcher receives NIH grant to study how chromatin modifiers regulate cell division

The National Institute of General Medical Sciences of the National Institutes of Health recently awarded Lori A. Pile, Ph.D., assistant professor of molecular cell biology in Wayne State University's College of Liberal Arts and Sciences, $1.39 million to research how the alteration of chromatin regulates cellular division and growth.

17 Aug 2011

Moderate alcohol intake on a regular basis may increase risk of obesity

A paper from Spain provides an extensive review of the association between alcohol consumption and body weight. Based on the fact that the energy content in 1 gram of alcohol is 29 kJ or 7.1 kcal, excessive alcohol consumption can lead to weight gain.

17 Aug 2011