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Gene therapy cocktail can treat inherited diseases with 'misfolded' proteins

In a kind of molecular gymnastics, scientists at the University of North Carolina at Chapel Hill School of Medicine have devised a gene therapy cocktail that has the potential to treat some inherited diseases associated with "misfolded" proteins.

16 Aug 2011

Pfizer, QIAGEN partner to develop diagnostic-therapeutic combination for NSCLC

QIAGEN today announced it has entered into a partnership with Pfizer Inc. for the development of a companion molecular diagnostic test for use with an investigational Pfizer compound in global clinical development for treatment of non-small cell lung cancer.

From QIAGEN Manchester Limited 16 Aug 2011

Researchers identify oncoprotein that allows MCV virus to trigger Merkel Cell Carcinoma

Researchers at the University of Pittsburgh Cancer Institute (UPCI) have identified the oncoprotein that allows a common and usually harmless virus to transform healthy cells into a rare but deadly skin cancer called Merkel Cell Carcinoma.

16 Aug 2011

Advanced MRI techniques can identify early OA

Researchers from NYU Langone Medical Center's Departments of Orthopaedic Surgery and Radiology found that advanced MRI techniques can be used to detect subtle changes in joint cartilage microstructure - and provide physicians a diagnostic tool for finding key markers of early osteoarthritis.

16 Aug 2011

Study suggests link between pre-pregnancy obesity and asthma symptoms in teen children

Mums who are overweight or obese when they become pregnant may be programming their children to have asthma-like respiratory symptoms during adolescence, suggests research published online in the Journal of Epidemiology and Community Health.

16 Aug 2011

Customized computer models may identify patients at risk of Lynch syndrome

People who are at risk for a certain form of colon and other types of cancer may soon have a better chance at surviving or even avoiding the diseases, thanks to a new study done by the Intermountain Clinical Genetics Institute at LDS Hospital.

16 Aug 2011

Prolonged TV viewing linked with reduced life expectancy

Watching TV for an average of six hours a day could shorten the viewer's life expectancy by almost five years, indicates research published online in the British Journal of Sports Medicine.

16 Aug 2011

Pericardial fat may promote atherosclerosis

Researchers have found more evidence supporting the role of fat around the heart in promoting atherosclerosis, according to a study published online in the journal Radiology.

16 Aug 2011

AHRQ's new Spanish-language guide on heart medications

A free, illustrated easy-to-read pamphlet that compares drugs for preventing heart attacks, heart failure or strokes in people with stable coronary heart disease is one of six new Spanish-language publications from HHS' Agency for Healthcare Research and Quality that help patients compare treatments for common illnesses.

16 Aug 2011

Combination immunotherapy more effective for patients with Sezary Syndrome

A three-pronged immunotherapy approach nearly doubles five-year survival among patients with rare leukemic form of cutaneous T-cell lymphoma, reports a new study by dermatologists from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania.

16 Aug 2011

EOSS could predict risk of death in overweight, obese people

A new tool - the Edmonton obesity staging system (EOSS) - improves on current methods to predict the risk of death in overweight and obese people, according to a study in CMAJ.

16 Aug 2011

Parents view children's nut allergies as 'frivolous and self-indulgent fad'

Parents of nut-allergy sufferers face hostility and scepticism in trying to find safe environments for their children, a new study has found.

16 Aug 2011

Caffeine might help prevent skin cancer

A new Rutgers study strengthens the theory that caffeine guards against certain skin cancers at the molecular level by inhibiting a protein enzyme in the skin, known as ATR. Scientists believe that based on what they have learned studying mice, caffeine applied directly to the skin might help prevent damaging UV light from causing skin cancer.

16 Aug 2011

Survey: 35% of people in the UK fear cancer more than other life-threatening conditions

More than a third of people in the UK fear cancer more than other life-threatening conditions - such as Alzheimer's, stroke and heart disease according to a Cancer Research UK survey.

16 Aug 2011

New pathway for type 2 diabetes

Newly diagnosed type 2 diabetics tend to have one thing in common: obesity. Exactly how diet and obesity trigger diabetes has long been the subject of intense scientific research.

16 Aug 2011

Research: Decoding infidelity may increase risk of type 2 diabetes

Type 2 diabetes is an extremely common chronic condition characterized by high levels of sugar in the blood as a result of either insufficient production of the hormone insulin or an inability of cells to respond to insulin.

16 Aug 2011

Regular exercise could help prevent brain damage linked with Alzheimer's

Regular exercise could help prevent brain damage associated with neurodegenerative diseases like Alzheimer's, according to research published this month in Elsevier's journal Brain, Behavior, and Immunity.

16 Aug 2011

Enrollment commences in Omthera's Epanova Phase III trial for hypertriglyceridemia

Omthera Pharmaceuticals, Inc., a privately-held emerging specialty pharmaceuticals company, announced today that the first patient has been enrolled in its ESPRIT Phase III clinical trial of Epanova, in patients with hypertriglyceridemia (TG level greater than or equal to 200 and < 500 mg/dL) despite treatment with a statin.

16 Aug 2011

New role for harmonin protein in Usher syndrome

University of Iowa scientists have discovered a new role for a protein that is mutated in Usher syndrome, one of the most common forms of deaf-blindness in humans. The findings, which were published Aug. 8 in Nature Neuroscience, may help explain why this mutation causes the most severe form of the condition.

16 Aug 2011

Alpha-synuclein protein key to Parkinson's has likely been mischaracterized

A new study finds that a protein key to Parkinson's disease has likely been mischaracterized. The protein, alpha-synuclein, appears to have a radically different structure in healthy cells than previously thought, challenging existing disease paradigms and suggesting a new therapeutic approach.

16 Aug 2011