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Study broadens understanding of role of IDH1 and IDH2 mutations in AML

Agios Pharmaceuticals, the leading biopharmaceutical company focused on discovering and developing novel drugs in the rapidly emerging field of cancer metabolism, today announced the publication of a paper in Cancer Cell that illuminates the mechanism by which 2-hydroxyglutarate (2HG), and the mutations in the metabolic genes IDH1 and IDH2 that produce it, may be driving the growth of tumors in patients with acute myeloid leukemia (AML).

15 Dec 2010

Study examines the impact on asthmatics related to common environmental mould

Scientists investigating the allergic reactions that asthmatics suffer towards a common mould have discovered that many people with asthma actually had the mould growing in their own lungs.

15 Dec 2010

New hypothesis emphasizes the value of anti-inflammatory approaches to prevent Alzheimer's disease

Karl Herrup thinks that the national research effort to understand Alzheimer-s disease has gone about as far as it can go with its current theories.

15 Dec 2010

Study suggests unexpected role for NLRP3 protein in cancer vaccine development

The promise of vaccines targeted against various types of cancer has raised the hopes of patients and their families. The reality, however, is that these promising treatments are difficult to develop. One of the challenges is identifying a discrete cellular target to stop cancer growth without inactivating the immune system. Scientists at UNC Lineberger Comprehensive Cancer Center report a laboratory finding that has the potential to increase the effectiveness of therapeutic cancer vaccines.

15 Dec 2010

Case study sheds light on pathological course of Alzheimer's disease

A case study from the Swedish medical university Karolinska Institutet sheds light on the pathological course of Alzheimer's disease. The brain of the first Alzheimer's patient to display amyloids demonstrable with a PET scanner has been studied, both during progression of the disease and after death.

15 Dec 2010

New HHS Strategy on Multiple Chronic Conditions

The U.S. Department of Health and Human Services today issued its new Strategic Framework on Multiple Chronic Conditions - an innovative private-public sector collaboration to coordinate responses to a growing challenge.

15 Dec 2010

NCI initiates crolibulin/cisplatin combination Phase II trial in anaplastic thyroid cancer

EpiCept Corporation today announced that the National Cancer Institute (NCI) has initiated a Phase II trial with crolibulinTM (EPC2407). The trial will assess the drug's efficacy and safety in combination with cisplatin in patients with anaplastic thyroid cancer (ATC). CrolibulinTM is a vascular disruption and apoptosis inducing agent that has demonstrated potent anti-tumor activity in both preclinical and early clinical studies.

15 Dec 2010

Sharing of scientific data could benefit cancer research

The sharing of scientific data in increasingly open ways could benefit cancer research and thus patients, according to a paper published in the peer-reviewed journal ecancermedicalscience.

15 Dec 2010

Angiogenesis inhibition is a validated strategy for cancer therapy

Scientists at the Dana-Farber Cancer Institute may have uncovered a mechanism for blocking tumor angiogenesis that involves the patient's immune system, according to findings published in Cancer Research, a journal of the American Association for Cancer Research.

15 Dec 2010

China Nuokang receives SFDA manufacturing license for Dipyridamole Aspirin

China Nuokang Bio-Pharmaceutical Inc., a leading China-based biopharmaceutical company focused on the research, development, manufacture, marketing and sales of hospital-based medical products, today announced that the Company has received the manufacturing license from the State Food and Drug Administration ("SFDA") for Dipyridamole Aspirin, a stroke-prevention product developed in-house.

15 Dec 2010

CRI introduces new model of philanthropic investment to improve cancer patient care

Cancer Research Institute, Inc. (CRI), a U.S. nonprofit organization established in 1953 to advance the science of tumor immunology and foster the discovery of new cancer immunotherapies, announced today the launch of the Cancer Vaccine Acceleration Fund (CVAF), a new model of philanthropic investment and academic-industry collaboration established in partnership with the Ludwig Institute for Cancer Research Ltd (LICR) to speed the clinical development of therapeutic cancer vaccines and other immune system-based therapies.

15 Dec 2010

Tumor suppressor p53 may serve as 'Guardian against Genome Reprogramming'

A close collaboration between researchers at the Salk Institute for Biological Studies and the Institute for Advanced Study found that the tumor suppressor p53, long thought of as the "Guardian of the Genome," may do more than thwart cancer-causing mutations. It may also prevent established cancer cells from sliding toward a more aggressive, stem-like state by serving as a "Guardian against Genome Reprogramming."

15 Dec 2010

BRIC researchers discover new protein that improves immune system

Researchers at BRIC, the University of Copenhagen, have discovered for the first time a protein normally found in the body that can act to prevent chronic tissue inflammation.

15 Dec 2010

Amira's clinical-stage DP2 receptor antagonist program data to be presented at Pacifichem 2010

Amira Pharmaceuticals, Inc. announced today that it will present preclinical and clinical data from its DP2 receptor antagonist program on December 17, 2010, at Pacifichem 2010 in Honolulu, Hawaii. The data from Amira's clinical-stage DP2 program will be delivered by Brian Stearns, Ph.D., in a presentation titled "Discovery and optimization of a novel series of DP2 antagonists with efficacy in mouse models of COPD and asthma."

15 Dec 2010

Anxious and depressed patients more likely to report worse results after hip replacement

Patients who suffer from anxiety and depression are more likely to report worse results after a hip replacement. A year-long wait for the operation also entails significant costs to both society and the individual, reveals a new thesis from the University of Gothenburg, Sweden.

15 Dec 2010

FP/TMEM127 gene germline mutations associated with adrenal gland tumors

Analysis has identified variations of a gene that are associated with a type of tumor that forms within the adrenal gland, according a study in the December 15 issue of JAMA. The age group in which these variations were found are frequently excluded from genetic screening models for this type of tumor.

15 Dec 2010

Lung protective strategy can increase the number of lungs available for transplant

Simple changes to how ventilators are used could almost double the number of lungs available for transplants, according to new international research involving a doctor at St. Michael's Hospital.

15 Dec 2010

Over expression of transcription factor improves neurological function in HD transgenic mice models

Over expressing a transcription factor that promotes the increase in number of mitochondria greatly improves the neurological function of transgenic mice models for Huntington's disease, researchers today told the American Society of Cell Biology's 50th Annual Meeting in Philadelphia.

15 Dec 2010

Research reveals mother's eating habits have huge impact on children's nutrition

As health professionals search for ways to combat the rise in obesity and promote healthy eating, new research reveals a mother's own eating habits - and whether she views her child as a 'picky eater' - has a huge impact on whether her child consumes enough fruits and vegetables.

15 Dec 2010

CGEN-15001 administration shows dramatic therapeutic potential in CIA animal model

Compugen Ltd. announced today that administration of CGEN-15001 in an animal model of rheumatoid arthritis dramatically ameliorates the clinical symptoms of the disease.

15 Dec 2010

Medical Condition News

Study broadens understanding of role of IDH1 and IDH2 mutations in AML

Study examines the impact on asthmatics related to common environmental mould

New hypothesis emphasizes the value of anti-inflammatory approaches to prevent Alzheimer's disease

Study suggests unexpected role for NLRP3 protein in cancer vaccine development

Case study sheds light on pathological course of Alzheimer's disease

New HHS Strategy on Multiple Chronic Conditions

NCI initiates crolibulin/cisplatin combination Phase II trial in anaplastic thyroid cancer

Sharing of scientific data could benefit cancer research

Angiogenesis inhibition is a validated strategy for cancer therapy

China Nuokang receives SFDA manufacturing license for Dipyridamole Aspirin

CRI introduces new model of philanthropic investment to improve cancer patient care

Tumor suppressor p53 may serve as 'Guardian against Genome Reprogramming'

BRIC researchers discover new protein that improves immune system

Amira's clinical-stage DP2 receptor antagonist program data to be presented at Pacifichem 2010

Anxious and depressed patients more likely to report worse results after hip replacement

FP/TMEM127 gene germline mutations associated with adrenal gland tumors

Lung protective strategy can increase the number of lungs available for transplant

Over expression of transcription factor improves neurological function in HD transgenic mice models

Research reveals mother's eating habits have huge impact on children's nutrition

CGEN-15001 administration shows dramatic therapeutic potential in CIA animal model

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

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