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Insulin resistance from obesity leads to lower cognitive performance in children: Research

A study by researchers at NYU Langone Medical Center have found that obese adolescents with type 2 diabetes have diminished cognitive performance and subtle abnormalities in the brain as detected by Magnetic Resonance Imaging (MRI). Identification of cognitive impairments as a complication of type 2 diabetes emphasizes the importance of addressing issues of inactivity and obesity, two important risk factors for the development of the disease among the young.

3 Aug 2010

First patient treated in Phase Ib expansion study of CUDC-101

Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that the first patient has been treated in a Phase Ib expansion study for CUDC-101 in patients with advanced head and neck, gastric, breast and liver cancers.

3 Aug 2010

Obesity-related Quality-Adjusted Life Years lost by U.S. adults doubles from 1993 to 2008

Although the prevalence of obesity and obesity-attributable deaths has steadily increased, the resultant burden of disease associated with obesity has not been well understood. A new study published in the September issue of the American Journal of Preventive Medicine indicates that Quality-Adjusted Life Years (QALYs) lost to U.S. adults due to morbidity and mortality from obesity have more than doubled from 1993-2008 and the prevalence of obesity has increased 89.9% during the same period.

3 Aug 2010

NWBT reports long-term follow-up data from DCVax-Brain immune therapy clinical trials for GBM

Northwest Biotherapeutics, Inc. today announced further positive long-term follow-up data from its prior Phase I and Phase I/II clinical trials, in which patients with newly diagnosed Glioblastoma multiforme ("GBM"), the most rapid and lethal type of brain cancer, were treated with NWBT's DCVax®-Brain personalized immune therapy.

3 Aug 2010

Recommendations available for managing ascites, SBP and hepatorenal syndrome

The peer reviewed guidelines will be available in the September 2010 issue, (Volume 53, No.3) of the Journal of Hepatology and online in advance of publication at http://www.ncbi.nlm.nih.gov/pubmed/20633946 . They also provide recommendations for the management of spontaneous bacterial peritonitis and hepatorenal syndrome, which often affect patients with cirrhosis.

3 Aug 2010

Research findings help shape long-term follow-up strategies for early stage lung cancer patients

In patients with non-small cell lung cancer, five-year disease-free survival is currently the benchmark of cure. However, there are two issues that remain with the follow-up standards: (1) When can cure be declared with confidence and (2) for how long should follow-up examination be continued?

3 Aug 2010

New publication on active middle ear implants

In recent years, methods for coupling active implants to the middle ear, round window or combinations of passive middle ear prostheses have progressed considerably. Patient selection criteria have expanded from purely sensorineural hearing losses to conductive and mixed hearing losses in difficult-to-treat ears.

3 Aug 2010

First successful procedures in Australia with GORE DrySeal Sheath for aortic aneurysms

W.L. Gore & Associates (Gore) announced today the first clinical cases in Australia involving the revolutionary GORE® DrySeal Sheath. The sheath aids in minimally invasive treatment of patients with abdominal aortic aneurysms (AAA) utilizing the GORE® EXCLUDER® AAA Endoprosthesis and thoracic aortic aneurysms (TAA) utilizing the GORE® TAG® Thoracic Endoprosthesis.

3 Aug 2010

Abnormal eye movements, neurobehavioral impairments common among relatives of patients with autism: Report

Abnormal eye movements and other sensorimotor and neurobehavioral impairments appear common in unaffected family members of individuals with autism, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

3 Aug 2010

Pairing adolescents with college student mentors keeps kids healthy, fit

A program pairing healthy young adults with urban middle school students helped the adolescents adopt healthy habits, active lifestyles and a healthy weight, according to a new study from the University of Maryland School of Medicine. The study, published August 2 in the journal Pediatrics, found that linking African American, inner city adolescents in Baltimore with one-on-one mentorship from college students prevented the schoolchildren from becoming overweight for at least two years after the mentorship experience. Researchers found the adolescents ate fewer snacks and desserts, and engaged in active play more often. The rate of overweight/obesity in the group declined five percent.

3 Aug 2010

Study finds hunger as a serious risk factor for long-term poor health among children, youth

Children and youth who experience hunger appear more likely to have health problems, and repeated episodes of hunger may be particularly toxic, according to a report in the August issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

3 Aug 2010

Toxic protein in bee venom improves liposome encapsulated drug effectiveness

The next time you are stung by a bee, here's some consolation: a toxic protein in bee venom, when altered, significantly improves the effectiveness liposome-encapsulated drugs or dyes, such as those already used to treat or diagnose cancer. This research, described in the August 2010 print issue of the FASEB Journal, shows how modified melittin may revolutionize treatments for cancer and perhaps other conditions, such as arthritis, cardiovascular disease, and serious infections.

3 Aug 2010

Antisense Pharma receives FDA IND authorisation for clinical studies with trabedersen for high-grade glioma

The biopharmaceutical company Antisense Pharma announced today that the US-American Food and Drug Administration (FDA) has issued an Investigational New Drug (IND)-authorisation for clinical studies with trabedersen for patients with high-grade glioma. This authorisation entitles the company to include US-American clinics both in the phase III study SAPPHIRE and in further studies.

3 Aug 2010

Study shows prevalence, severity of dyspnea in long-term lung cancer survivors

With the growing number of long-term lung cancer survivors, research is needed to identify and address cancer survivorship issues. One of the most common and debilitating symptoms among lung cancer patients is dyspnea, or shortness of breath. As most studies of dyspnea have reviewed patients with active lung cancer or immediately after treatment, the prevalence of dyspnea over the long-term once treatment has been completed is not well characterized.

3 Aug 2010

Way patients cope with diabetes-related foot ulcers and their levels of depression affect wound healing

People suffering from diabetes-related foot ulcers show different rates of healing according to the way they cope and their psychological state of mind, according to new research by a health psychologist at The University of Nottingham.

3 Aug 2010

Particles of iron oxide enhance tumor visibility through MRI

Tiny particles of iron oxide could become tools for simultaneous tumor imaging and treatment, because of their magnetic properties and toxic effects against brain cancer cells. In mice, researchers from Emory University School of Medicine have demonstrated how these particles can deliver antibodies to implanted brain tumors, while enhancing tumor visibility via magnetic resonance imaging (MRI).

3 Aug 2010

PHD1 useful for pharmacologic inhibition in IBD: Research

Research into inflammatory bowel disease (IBD) led by UCD Conway Institute scientists with national and international collaborators has identified a key regulator involved in maintaining the functional integrity of the gut lining. The findings, published recently in the scientific journal, Gastroenterology, provide information that may be important in developing a new therapeutic approach to the treatment of the disease.

3 Aug 2010

ArQule, Daiichi Sankyo announce decision to advance ARQ 197 into Phase 3 clinical trial for NSCLC

ArQule, Inc. and Daiichi Sankyo Co., Ltd. today announced that they will move forward with a Phase 3 clinical trial of ARQ 197, a small molecule inhibitor of the c-Met receptor tyrosine kinase, in patients with non-small cell lung cancer (NSCLC). In connection with this decision, the sponsor company, Daiichi Sankyo, will file a Special Protocol Assessment (SPA) with the U.S. Food and Drug Administration (FDA) for a trial comparing ARQ 197 plus erlotinib against erlotinib plus placebo.

3 Aug 2010

Using internet can develop depression among teens

Teens who use the Internet pathologically appear more likely to develop depression than those who do not, according to a report posted online today that will appear in the October print issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

3 Aug 2010

Study finds low carbohydrate diet may help improve cardiovascular risk factors

The effectiveness of a low-carbohydrate diet versus a low-fat diet for weight loss have been frequently debated. According to a new study published in Annals of Internal Medicine, both diets produce identical weight loss when coupled with comprehensive behavior treatment, but a low-carbohydrate diet may help improve cardiovascular risk factors.

3 Aug 2010

Medical Condition News

Insulin resistance from obesity leads to lower cognitive performance in children: Research

First patient treated in Phase Ib expansion study of CUDC-101

Obesity-related Quality-Adjusted Life Years lost by U.S. adults doubles from 1993 to 2008

NWBT reports long-term follow-up data from DCVax-Brain immune therapy clinical trials for GBM

Recommendations available for managing ascites, SBP and hepatorenal syndrome

Research findings help shape long-term follow-up strategies for early stage lung cancer patients

New publication on active middle ear implants

First successful procedures in Australia with GORE DrySeal Sheath for aortic aneurysms

Abnormal eye movements, neurobehavioral impairments common among relatives of patients with autism: Report

Pairing adolescents with college student mentors keeps kids healthy, fit

Study finds hunger as a serious risk factor for long-term poor health among children, youth

Toxic protein in bee venom improves liposome encapsulated drug effectiveness

Antisense Pharma receives FDA IND authorisation for clinical studies with trabedersen for high-grade glioma

Study shows prevalence, severity of dyspnea in long-term lung cancer survivors

Way patients cope with diabetes-related foot ulcers and their levels of depression affect wound healing

Particles of iron oxide enhance tumor visibility through MRI

PHD1 useful for pharmacologic inhibition in IBD: Research

ArQule, Daiichi Sankyo announce decision to advance ARQ 197 into Phase 3 clinical trial for NSCLC

Using internet can develop depression among teens

Study finds low carbohydrate diet may help improve cardiovascular risk factors

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications

Precision in every drop: Inside Hamilton’s syringe technology

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