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Study finds decrease in newly registered NIH-funded trials compared to industry-funded trials

From 2006 through 2014, there was a decrease in newly registered NIH-funded trials, whereas industry-funded trials increased substantially, based on trials registered in ClinicalTrials.gov. The study appears in the December 15 issue of JAMA.

16 Dec 2015

Hematopoietic stem cell transplantation does not provide improvement for patients with Crohn disease

Among adults with difficult to treat Crohn disease not amenable to surgery, hematopoietic stem cell transplantation, compared with conventional therapy, did not result in significant improvement in sustained disease remission at l year and was associated with significant toxicity, according to a study in the December 15 issue of JAMA.

16 Dec 2015

Use of tumor-treating fields along with chemotherapy improves survival in patients with brain tumor

Early research indicates that the use of tumor-treating fields, a type of electromagnetic field therapy, along with chemotherapy in patients with a brain tumor who had completed standard chemoradiation resulted in prolonged progression-free and overall survival, according to a study in the December 15 issue of JAMA.

16 Dec 2015

Human-gut-on-a-chip model offers hope for patients suffering from IBD

It's estimated that as many as 1,000,000 Americans suffer from inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, which cause mild to severe symptoms that at best can be managed and at worst can lead to life-threatening complications.

16 Dec 2015

CTE can be diagnosed by neuropathological examination of brain tissue

For the first time, CTE has been confirmed as a unique disease that can be definitively diagnosed by neuropathological examination of brain tissue. A consensus panel of expert neuropathologists concluded that CTE has a pathognomonic signature in the brain, an advance that represents a milestone for CTE research and lays the foundation for future studies defining the clinical symptoms, genetic risk factors and therapeutic strategies for CTE.

16 Dec 2015

Bile acid may help treat fatty liver disease and obesity

A bile acid that can turn off a receptor in the gut has prevented and reversed fatty liver disease in mice, according to an international team of researchers. The compound may help treat certain metabolic disorders, such as Type 2 diabetes and obesity, as well.

16 Dec 2015

Simple diagnostic test can help fight deadly sleeping sickness

Scientists have developed a quick and simple diagnosis method, similar to a dipstick pregnancy test, to fight a deadly sleeping sickness.

16 Dec 2015

Researchers identify dazzling new method for visualizing neurons

Researchers have discovered a dazzling new method of visualizing neurons that promises to benefit neuroscientists and cell biologists alike: by using spectral confocal microscopy to image tissues impregnated with silver or gold.

16 Dec 2015

IIASA researchers provide new measures to replace old-age dependency ratio

Conventional measures of age usually define people as 'old' at one chronological age, often 65. In many countries around the world, age 65 is used as a cutoff for everything from pension age to health care systems, as the basis of a demographic measure known as the 'old-age dependency ratio,' which defines everyone over 65 as depending on the population between ages 20 and 65.

16 Dec 2015

TSRI scientists track how HIV-fighting antibodies develop over time

In a new study, a team led by scientists at The Scripps Research Institute tracked how a family of these HIV-fighting antibodies develops over time. The research shows how a future vaccine might trigger the immune system to produce these antibodies more effectively.

16 Dec 2015

Older adults experience problems in processing multisensory information

Much like trying to watch a video with the audio out of synch, older adults may have difficulty combining the stimuli they see and hear, and it could have implications for rapid decision-making tasks such as driving, according to new research.

16 Dec 2015

Patients can be trained to safely self-administer long-term IV antibiotics, say UT Southwestern physicians

Uninsured patients can be trained to safely and efficiently self-administer long-term intravenous antibiotics, UT Southwestern Medical Center physicians have found, a result that may have profound implications for patient treatment at public hospitals across the country.

16 Dec 2015

Prophylaxis treatment can protect children who receive liver transplants from HBV-infected donors

Researchers have found that a prophylaxis treatment can prevent new-onset hepatitis B in children who receive liver transplants from donors who were previously infected with hepatitis B virus (HBV) but had successfully cleared the virus.

16 Dec 2015

Study: Preoperative use of blood-thinning drugs associated with decreased risk of blood clots

Among patients undergoing major cancer operations, the preoperative use of blood-thinning drugs such as heparin does not increase rates of major bleeding or transfusions, and is associated with a decreased risk of blood clots, according to new study results published online in the Journal of the American College of Surgeons ahead of print publication early next year.

16 Dec 2015

New study may help understand how estrogens affect cognition and memory in women

A new study by University of Guelph researchers that narrows down where and how estrogens affect the brain may help in understanding how the hormones affect cognition and memory in women, says psychology professor Elena Choleris.

16 Dec 2015

BUSM researchers explore how do not resuscitate orders affect hospital rankings for pneumonia

Researchers from Boston University School of Medicine examined how hospital differences in patient preferences for life-sustaining treatments (do not resuscitate, or DNR, orders) affected hospital rankings for pneumonia.

16 Dec 2015

Molecular signatures can predict flu vaccine responses in young and old

What factors inhibit strong responses to seasonal flu vaccines in the elderly? Why do anti-flu antibodies last longer after vaccination in some people? Answers are emerging from an Emory University-based systems biology analysis of blood samples from more than 400 volunteers who received seasonal flu vaccines. Bali Pulendran, PhD, led a team of researchers who tracked patterns of gene expression, known as molecular signatures, of strong immune responses in volunteers' blood across five consecutive seasons from 2007 to 2011.

16 Dec 2015

Cancer drug may protect kidneys from damage caused by chemotherapy agent cisplatin

A class of drugs used increasingly to help fight cancer may have the additional benefit of protecting the kidneys when packaged with the powerful chemotherapy agent cisplatin.

16 Dec 2015

U of T researchers find another clue in understanding the cause of MS

Researchers at the University of Toronto have found another clue in understanding the cause of what drives Multiple Sclerosis (MS) disease. Their findings were published today in Immunity.

16 Dec 2015

Innovative brain imaging study reveals why ToM deficiencies present in children with ASD

The holidays can be difficult for children with autism spectrum disorder (ASD), particularly because of new or different social situations. One reason scientists believe ASD causes impairment in social interactions is due to an inability to effectively infer other's thoughts and feelings through "theory of mind," or ToM -- the ability to understand the mental states of others and oneself.

16 Dec 2015

Medical Research News

Study finds decrease in newly registered NIH-funded trials compared to industry-funded trials

Hematopoietic stem cell transplantation does not provide improvement for patients with Crohn disease

Use of tumor-treating fields along with chemotherapy improves survival in patients with brain tumor

Human-gut-on-a-chip model offers hope for patients suffering from IBD

CTE can be diagnosed by neuropathological examination of brain tissue

Bile acid may help treat fatty liver disease and obesity

Simple diagnostic test can help fight deadly sleeping sickness

Researchers identify dazzling new method for visualizing neurons

IIASA researchers provide new measures to replace old-age dependency ratio

TSRI scientists track how HIV-fighting antibodies develop over time

Older adults experience problems in processing multisensory information

Patients can be trained to safely self-administer long-term IV antibiotics, say UT Southwestern physicians

Prophylaxis treatment can protect children who receive liver transplants from HBV-infected donors

Study: Preoperative use of blood-thinning drugs associated with decreased risk of blood clots

New study may help understand how estrogens affect cognition and memory in women

BUSM researchers explore how do not resuscitate orders affect hospital rankings for pneumonia

Molecular signatures can predict flu vaccine responses in young and old

Cancer drug may protect kidneys from damage caused by chemotherapy agent cisplatin

U of T researchers find another clue in understanding the cause of MS

Innovative brain imaging study reveals why ToM deficiencies present in children with ASD

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

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