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Administering TXA through IV and IA can reduce blood loss following total knee replacement

A new study appearing in the Journal of Bone and Joint Surgery found that administering tranexamic acid (TXA) both intravenously (IV) and injected at the surgical site (intra-articular administration, or IA) reduced blood loss by 37 percent, compared to IV alone, following total knee replacement (TKR).

22 May 2016

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

For cancer to spread, the cells that take off into the bloodstream must find a tissue that will permit them to thrive. They don't just go looking, though. Instead, they actively prepare the tissue, in one case by co-opting a protein that suppresses defenses the body would otherwise mount.

21 May 2016

Two-way communication between cancer cells may be key to tumor metastasis

Two-way communication between cancer cells appears to be key to their becoming motile, clustering and spreading through metastasis, according to Rice University scientists.

21 May 2016

Research provides pathway toward creation of first broad-spectrum antiviral drug

By studying the rare person -- about one in a million -- who can fight off viral infections more effectively than everyone else, investigators at the Icahn School of Medicine at Mount Sinai have developed a strategy to help the rest of us achieve this enhanced anti-viral state.

21 May 2016

Intensive blood pressure lowering therapies can cut heart disease risk in older adults

Intensive therapies to reduce high blood pressure can cut the risk of heart disease in older adults without increasing the risk for falls, according to doctors at Wake Forest Baptist Medical Center.

21 May 2016

Regular use of laxatives may flatten rigidity found in Parkinson's disease

In a recent retrospective analysis, investigators discovered that the year-on-year increase in rigidity found in Parkinson's disease flattened off with the regular use of laxatives to manage constipation.

21 May 2016

GMU’s early-detection urine test works for Lyme disease, study shows

After three years and 300 patients, George Mason University researchers have proof that their early-detection urine test for Lyme disease works.

21 May 2016

LIGR-Seq tool opens door to developing new understanding of ncRNA function

What used to be dismissed by many as "junk DNA" is back with a vengeance as growing data points to the importance of non-coding RNAs (ncRNAs) -- genome's messages that do not code for proteins -- in development and disease.

21 May 2016

Umea University researchers find link between vitamin E and brain tumours

Researchers at Umea University in Sweden and the Cancer Registry of Norway have studied possible causes behind the development of brain tumours.

21 May 2016

New experimental model may predict eventual cardiac phenotype in pediatric patients

An experimental model uses genetics-guided biomechanics and patient-derived stem cells to predict what type of inherited heart defect a child will develop, according to authors of a new study in the journal Cell.

21 May 2016

Four major phenotypes may help improve prediction, prevention of cardiometabolic risk in prediabetes

Prediabetes is associated with increased risk of diabetes, cardiovascular disease, dementia and cancer. However, the disease risk considerably varies among subjects.

21 May 2016

Cardioprotective effect proposed for metformin

A large retrospective analysis suggests that metformin could be cardioprotective in insulin-dependent patients with Type 2 diabetes.

21 May 2016

SPRINT supports stringent BP goals for elderly

Analysis of SPRINT participants older than 75 years shows that they too benefitted from an intensive blood pressure target of 120 mmHg.

20 May 2016

Novel protective gene against CAD uncovered

A large study has found that mutations in the gene encoding the major subunit of the asialoglycoprotein receptor are protective against coronary artery disease.

20 May 2016

Friendships, supportive family environments may help protect teens from depression

The importance of friendships and family support in helping prevent depression among teenagers has been highlighted in research from the University of Cambridge.

20 May 2016

Specific monocyte immune cells serve as link between gut bacteria and the brain

A special kind of immune cell serves as an intermediary between gut bacteria and the brain. Dr. Susanne Wolf of the Max Delbruck Center for Molecular Medicine in the Helmholtz Association discovered this in tests on mice and published her findings in the journal Cell Reports.

20 May 2016

Malicious form of ATF2 protein drives formation of melanoma

An international collaborative study led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a malicious form of a protein that drives the formation of melanoma.

20 May 2016

Researchers urge specific guidelines for fertility, sexual function counseling in at-risk pediatric patients

The drugs and therapies used to treat medical conditions often come with side effects. Doctors, pharmacists and other health care professionals strive to be sure we are made aware.

20 May 2016

New study aims to identify biomarkers linked to cartilage degradation in OA patients

Joint injury can lead to post-traumatic osteoarthritis (PTOA). In fact, about half of all people who rupture the anterior cruciate ligament (ACL) in their knee will develop PTOA within 10-20 years of the injury.

20 May 2016

High levels of p62 protein in liver linked to cancer recurrence

Researchers at University of California San Diego School of Medicine and Sanford Burnham Prebys Medical Discovery Institute have discovered that high levels of the protein p62 in human liver samples are strongly associated with cancer recurrence and reduced patient survival.

20 May 2016

Medical Research News

Administering TXA through IV and IA can reduce blood loss following total knee replacement

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

Two-way communication between cancer cells may be key to tumor metastasis

Research provides pathway toward creation of first broad-spectrum antiviral drug

Intensive blood pressure lowering therapies can cut heart disease risk in older adults

Regular use of laxatives may flatten rigidity found in Parkinson's disease

GMU’s early-detection urine test works for Lyme disease, study shows

LIGR-Seq tool opens door to developing new understanding of ncRNA function

Umea University researchers find link between vitamin E and brain tumours

New experimental model may predict eventual cardiac phenotype in pediatric patients

Four major phenotypes may help improve prediction, prevention of cardiometabolic risk in prediabetes

Cardioprotective effect proposed for metformin

SPRINT supports stringent BP goals for elderly

Novel protective gene against CAD uncovered

Friendships, supportive family environments may help protect teens from depression

Specific monocyte immune cells serve as link between gut bacteria and the brain

Malicious form of ATF2 protein drives formation of melanoma

Researchers urge specific guidelines for fertility, sexual function counseling in at-risk pediatric patients

New study aims to identify biomarkers linked to cartilage degradation in OA patients

High levels of p62 protein in liver linked to cancer recurrence

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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