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CHEST guideline released for PAH

An updated CHEST guideline for treating pulmonary arterial hypertension provides some evidence-based recommendations but also highlights many evidence gaps.

15 Jul 2014

Inflammatory shift in long-standing bipolar disorder

Patients with chronic bipolar disorder, but not those with schizophrenia, have a shift towards an M1 rather than an M2 macrophage response, research suggests.

15 Jul 2014

Motivational impairment could be early target for psychosis risk

Research suggests that motivational impairment may be present before psychosis onset but does not worsen over the course of the illness.

15 Jul 2014

Very-late-onset schizophrenia linked to particularly high mortality risk

Patients with very-late-onset schizophrenia-like psychosis have an increased risk of death compared with both the general population and patients with schizophrenia diagnosed earlier in life, Finnish study findings indicate.

15 Jul 2014

Openness predicts cognitive function in bipolar disorder

The degree of Openness to Experiences reported by patients with bipolar disorder could be used to identify potential candidates requiring more comprehensive cognitive assessments, US researchers report.

15 Jul 2014

Urge incontinence therapy may relieve stress incontinence

Anticholinergic medication appears to be effective as a treatment for stress and mixed urinary incontinence, results of a small clinical trial indicate.

15 Jul 2014

Nocturia affects one in three premenopausal women

Nocturia affects around one-third of women of reproductive age, a survey has found, highlighting that the condition is not confined to elderly individuals.

15 Jul 2014

Japanese SF-MPQ valid for neuropathic and non-neuropathic pain

Researchers have developed a Japanese translated version of the Short-Form McGill Pain Questionnaire-2 that shows good reliability and validity for discriminating between chronic neuropathic and non-neuropathic pain.

15 Jul 2014

Localised inflammation found in eosinophilic otitis media

Antigen-specific immunoglobulin E is produced locally in the middle ear mucosa of patients with eosinophilic otitis media, clinical research indicates.

15 Jul 2014

Night-time BP variability improves vascular risk prediction

Measuring night-time variability in the blood pressure of patients with hypertension may help to predict their risk of having a cardiovascular event, show data from an international study.

15 Jul 2014

‘No convincing evidence’ for zinc supplements to prevent otitis media

There is no convincing evidence that zinc supplements reduce the risk of otitis media in children or adults, say the authors of an updated Cochrane review.

15 Jul 2014

PAH disease burden ‘significant’

Patients with newly diagnosed pulmonary arterial hypertension have a substantial burden of disease, with more than half hospitalised during the first 3 years post-diagnosis, research shows.

15 Jul 2014

Imaging biomarker proposed for Parkinson’s disease

Reduced off-medication connectivity in the basal ganglia network separates patients with early Parkinson’s disease from healthy controls with high accuracy, preliminary findings suggest.

15 Jul 2014

New avenues for treatment of Alzheimer's disease

Judes Poirier, PhD, C.Q., from the Douglas Mental Health Institute and McGill University in Montr-al (Canada) and his team have discovered that a relatively frequent genetic variant actually conveys significant protection against the common form of Alzheimer's disease and can delay the onset of the disease by as much as 4 years.

15 Jul 2014

Validity of DSM-5 change to age of onset criterion for diagnosis of ADHD

A recent study published in the July 2014 issue of the Journal of the American Academy of Child and Adolescent Psychiatry confirms the validity of the DSM-5 change to the age of onset criterion for diagnosis of attention-deficit/hyperactivity disorder (ADHD).

15 Jul 2014

Neuroprotective effects of ginsenoside Rb1 on hippocampal neuronal injury, neurite outgrowth

The main pathological changes of Alzheimer's disease (AD) include amyloid-beta protein-induced hippocampal neuronal injury and neurite outgrowth impairment.

15 Jul 2014

Apparent diffusion coefficient does not reflect cytotoxicedema on uninjured side after TBI

It is currently difficult to treat traumatic brain injury (TBI) in the clinic. There are abundant neural network connections and humoral regulation mechanisms between the cerebral hemispheres.

15 Jul 2014

B vitamins do not prevent Alzheimer's disease

Taking B vitamins doesn't slow mental decline as we age, nor is it likely to prevent Alzheimer's disease, conclude Oxford University researchers who have assembled all the best clinical trial data involving 22,000 people to offer a final answer on this debate.

15 Jul 2014

85% of African American adults expressed interest in genetic testing for AD susceptibility

Alcohol dependence (AD) has a genetic component and testing can determine a person's genetic risk for susceptibility to AD.

15 Jul 2014

New method for identifying patients with newly diagnosed HIV using electronic medical records

A new, validated software-based method for identifying patients with newly diagnosed HIV using electronic medical records (EMRs) is described in AIDS Research and Human Retroviruses, a peer-reviewed journal published by Mary Ann Liebert, Inc., publishers.

15 Jul 2014