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Phase III trial shows afatinib offers clinical benefit to patients with EGFR mutation positive NSCLC

Afatinib has a novel mode of action and data has shown that it offers a clinical benefit to patients with a specific type of lung cancer, which we are further investigating in the extensive LUX-Lung clinical trial programme.

1 Aug 2013

Experts say action needed urgently to ensure India's new policy does not backfire

In an editorial published online today in BMJ, Johns Hopkins bioethicist Jeremy Sugarman and other experts warn that action is urgently needed to deal with possible unintended consequences of India's new policy protecting research participants.

1 Aug 2013

Oxytocin hormone affects men and women differently, research finds

"The Love Hormone", Oxytocin affects men and women differently in social contexts- in men it improves the ability to identify competitive relationships whereas in women it facilitates the ability to identify kinship. "These findings are in agreement with previous studies on the social differences between the sexes: women tend to be more communal and familial in their behavior, whereas men are more inclined to be competitive and striving to improve their social status", said Prof. Simone Shamay-Tsoory from the Dept. of Psychology at the University of Haifa who led the research.

1 Aug 2013

Naked mole rat: A fitting model for finding novel ways to fight cancer

Mice and rats have long since been a standard animal model for cancer research, mainly due to their short lifespan of four years on average and high incidence of cancer. Naked mole rats however, are a mystery among mammals. This social tiny African subterranean rodent has a maximum lifespan exceeding 30 years and most surprisingly, is cancer-resistant.

1 Aug 2013

Transmembrane protein NG2 controls orientation of cell migration toward the wound

When the central nervous system is injured, oligodendrocyte precursor cells migrate to the lesion and synthesize new myelin sheaths on demyelinated axons. Scientists at the Institute of Molecular Cell Biology at Johannes Gutenberg University Mainz have now discovered that a distinct protein regulates the direction and movement of OPC toward the wound. The transmembrane protein NG2, which is expressed at the surface of OPCs and down-regulated as they mature to myelinating oligodendrocytes, plays an important role in the reaction of OPC to wounding.

1 Aug 2013

New approach could provide alternative treatment for chemotherapy-resistant breast cancer

A new way to target a breast cancer cells' appetite for over-indulging in sugar, that could provide an alternative treatment for chemotherapy resistant breast cancer, is being developed by Breast Cancer Campaign scientists at the University of Southampton.

1 Aug 2013

Researcher receives grant to study how exposure to social stress impacts the brain and behavior

Dr. Kim Huhman, a researcher in the Center for Behavioral Neuroscience at Georgia State University, has received a federal five-year, $1.8 million grant for research that may lead to improved strategies for treating and preventing mental health problems associated with exposure to social stress.

1 Aug 2013

Finding could influence effectiveness of bone marrow transplants for late-stage leukemia

Eight years ago, two former Stanford University postdoctoral fellows, one of them still in California and the other at the Harvard Stem Cell Institute in Cambridge, began exchanging theories about why patients with leukemia stop producing healthy blood cells. What was it, they asked, that caused bone marrow to stop producing normal blood-producing cells?

1 Aug 2013

New NIH projects to target Fragile X syndrome, nicotine addiction and AMD

The National Institutes of Health has launched three innovative projects that will focus on development of therapeutics for Fragile X syndrome, nicotine addiction, and age-related macular degeneration. These projects are funded through the NIH Blueprint Neurotherapeutics Network which provides access to a variety of drug development resources.

1 Aug 2013

Researchers find new way to help surgeons more accurately plan for epilepsy surgery

A brain imaging research team led by Simon Fraser University neuroscientist Dr. Ryan D'Arcy has found a new way to help surgeons more accurately plan for surgical treatment in epilepsy.

1 Aug 2013

NIH-funded study finds that rituximab is as effective as standard therapy for severe vasculitis

Administering the drug rituximab once weekly for one month provides the same benefits as 18 months of daily immunosuppressive therapy in people with severe forms of vasculitis, or inflammation of the blood vessels, a study has found.

1 Aug 2013

Miniscule signaling molecule plays critical role in certain acute and chronic diseases

Scientists seeking to harness the healing power of a miniscule signaling molecule that plays a critical role in certain acute and chronic diseases have been awarded a Program Project Grant (PPG) of nearly $10 million by the National Heart, Lung and Blood Institute of the National Institutes of Health.

1 Aug 2013

Washing down sugary breakfast cereal with milk after eating may prevent cavities

Washing down sugary breakfast cereal with milk after eating reduces plaque acid levels and may prevent damage to tooth enamel that leads to cavities, according to new research at the University of Illinois at Chicago College of Dentistry.

1 Aug 2013

Study: Anemia may increase risk of dementia

Anemia, or low levels of red blood cells, may increase the risk of dementia, according to a study published in the July 31, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.

1 Aug 2013

Genetics could help women at risk of developing gestational diabetes

New Northwestern Medicine- research on the genetics of diabetes could one day help women know their risk for developing gestational diabetes before they become pregnant -- and lead to preventive measures to protect the health of offspring.

1 Aug 2013

New model shows how excessive calorie intake affects weight of children

A new study published in The Lancet Diabetes & Endocrinology reveals a sophisticated new model showing how excessive calorie intake affects the weight of children and adolescents, which could lead to improved weight loss interventions for obese and overweight children.

31 Jul 2013

Severe arthritis pain treatments: an interview with Professor Walsh, University of Nottingham and Professor Wood, UCL

Pain is defined by the sufferer’s experience. Pain may be severe because it is intense, frequent or sustained, and because it is distressing. The severity of pain is not simply due to what is going on in the joint, but is also affected by how the body processes the pain signals, and the context in which it is experienced.

31 Jul 2013

Chemists develop new method for parallel protein analysis

Chemists at Johannes Gutenberg University Mainz (JGU) have developed a new method for parallel protein analysis that is, in principle, capable of identifying hundreds or even thousands of different proteins. It could be used to detect the presence of viruses and identify their type in tiny samples. At the same time, it is very cost-effective and quick.

31 Jul 2013

Researchers identify stem cells in urine can be directed to become multiple cell types

Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types.

31 Jul 2013

Study: Full Body Illusions can be accompanied by changes in body temperature

Researchers from the Center for Neuroprosthetics at the Swiss Federal Institute of Technology (EPFL), Switzerland, show that people can be "tricked" into feeling that an image of a human figure -- an "avatar" -- is their own body. The study is published in the open-access journal Frontiers in Behavioral Neuroscience.

31 Jul 2013

Medical Research News

Phase III trial shows afatinib offers clinical benefit to patients with EGFR mutation positive NSCLC

Experts say action needed urgently to ensure India's new policy does not backfire

Oxytocin hormone affects men and women differently, research finds

Naked mole rat: A fitting model for finding novel ways to fight cancer

Transmembrane protein NG2 controls orientation of cell migration toward the wound

New approach could provide alternative treatment for chemotherapy-resistant breast cancer

Researcher receives grant to study how exposure to social stress impacts the brain and behavior

Finding could influence effectiveness of bone marrow transplants for late-stage leukemia

New NIH projects to target Fragile X syndrome, nicotine addiction and AMD

Researchers find new way to help surgeons more accurately plan for epilepsy surgery

NIH-funded study finds that rituximab is as effective as standard therapy for severe vasculitis

Miniscule signaling molecule plays critical role in certain acute and chronic diseases

Washing down sugary breakfast cereal with milk after eating may prevent cavities

Study: Anemia may increase risk of dementia

Genetics could help women at risk of developing gestational diabetes

New model shows how excessive calorie intake affects weight of children

Severe arthritis pain treatments: an interview with Professor Walsh, University of Nottingham and Professor Wood, UCL

Chemists develop new method for parallel protein analysis

Researchers identify stem cells in urine can be directed to become multiple cell types

Study: Full Body Illusions can be accompanied by changes in body temperature

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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